Abstract:
:After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals. In this study, twenty-four actinobacteria strains isolated from workers of Trachymyrmex ants were evaluated for antifungal activity towards a variety of Candida species. Results revealed that seven strains inhibited the tested Candida species. Streptomyces sp. TD025 presented potent and broad spectrum of inhibition of Candida and was selected for the isolation of bioactive molecules. From liquid shake culture of this bacterium, we isolated the rare antimycin urauchimycins A and B. For the first time, these molecules were evaluated for antifungal activity against medically important Candida species. Both antimycins showed antifungal activity, especially urauchimycin B. This compound inhibited the growth of all Candida species tested, with minimum inhibitory concentration values equivalent to the antifungal nystatin. Our results concur with the predictions that the attine ant-microbe symbiosis may be a source of bioactive metabolites for biotechnology and medical applications.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Mendes TD,Borges WS,Rodrigues A,Solomon SE,Vieira PC,Duarte MC,Pagnocca FCdoi
10.1155/2013/835081subject
Has Abstractpub_date
2013-01-01 00:00:00pages
835081eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract:BACKGROUND AND AIM:Chemokine/receptor axis is a predominant actor of clinical disorders. They are key factors of pathogenesis of almost all clinical situations including asthma. Correspondingly, CXCL12 is involved in the immune responses. Therefore, this study was designed to explore the association between gene polymo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/759361
更新日期:2013-01-01 00:00:00
abstract::Ablative therapies have been utilized with increasing frequency for the treatment of Barrett's esophagus with and without dysplasia. Multiple modalities are available for topical ablation of the esophagus, but radiofrequency ablation (RFA) remains the most commonly used. There have been significant advances in techniq...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/642063
更新日期:2014-01-01 00:00:00
abstract:OBJECT:The aim of this report was to explore the clinical presentation, radiological features, treatment methods, and outcome of micro-AVMs presenting with intracerebral hemorrhage. METHODS:The clinical data, radiological features, treatment, and follow-up results for a consecutive series of 13 cases with micro-AVMs w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/257153
更新日期:2015-01-01 00:00:00
abstract:Background:Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by sacroiliitis and spinal rigidity of the axial joints. The role of oxidative stress and increased proinflammatory cytokines is well documented in AS pathogenesis. Punicalagin (2,3-hexahydroxydiphenoyl-gallagyl-D-glucose), an ellagi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4918239
更新日期:2020-09-23 00:00:00
abstract:Background:Reproductive system cancer is an important cause of morbidity and mortality worldwide which threatens women's health and lives. Breast, cervical, and ovarian cancer have the higher incidence and mortality among a series of gynecology malignant tumor. We aimed to compare and assess the temporal trends of comm...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5307459
更新日期:2018-03-21 00:00:00
abstract:Objective:We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods:Overall 185 patients were enrolled. In t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7617148
更新日期:2017-01-01 00:00:00
abstract:Purpose:To analyze retrospectively the clinical efficacy and safety for patients treated with fractionated stereotactic radiation therapy (FSRT) using volumetric modulated arc therapy. Methods:Between 2016 and 2017, 46 patients with solitary brain metastasis who underwent FSRT consisting of 25-40 Gy/5 fractions were r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6342057
更新日期:2020-09-09 00:00:00
abstract::Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ. We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/197183
更新日期:2015-01-01 00:00:00
abstract::Photosystem II photochemistry and phycobiliprotein (PBP) genes of red algae Kappaphycus alvarezii, raw material of κ -carrageenan used in food and pharmaceutical industries, were analyzed in this study. Minimum saturating irradiance (I k) of this algal species was less than 115 μmol m(-2) s(-1). Its actual PSII effici...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/256549
更新日期:2013-01-01 00:00:00
abstract::The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/462179
更新日期:2013-01-01 00:00:00
abstract::One of the most important tasks of a living organism is to maintain its genetic integrity with respect to stress. Endoplasmic reticulum (ER) has a crucial role in sensing cellular homeostasis by controlling metabolism, proteostasis, and several signaling processes. ER stressors can induce autophagy-dependent survival;...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/319589
更新日期:2015-01-01 00:00:00
abstract:Purpose:High tibial osteotomy (HTO) has been adopted as an effective surgery for medial degeneration of the osteoarthritis (OA) knee. However, satisfactory outcomes necessitate the precise creation and distraction of osteotomized wedges and the use of intraoperative X-ray images to continually monitor the wedge-related...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9246529
更新日期:2018-05-08 00:00:00
abstract:INTRODUCTION:Severe sepsis and septic shock are the primary causes of multiple organ dysfunction syndrome (MODS), which is the most frequent cause of death in intensive care unit patients. Many pro- and anti-inflammatory mediators, such as interleukin-6 (IL-6), play a strategic role in septic syndrome. Continuous renal...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/108951
更新日期:2013-01-01 00:00:00
abstract::We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, whi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/976362
更新日期:2015-01-01 00:00:00
abstract::Human cytoplasmic alpha-fetoprotein (AFP) has been classified as a member of the albuminoid gene family. The protein sequence of AFP has significant homology to that of human serum albumin (HSA), but its biological characteristics are vastly different from HSA. The AFP functions as a regulator in the phosphatidylinosi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/256916
更新日期:2015-01-01 00:00:00
abstract::It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer's d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/214618
更新日期:2015-01-01 00:00:00
abstract::Effective alteration of the recalcitrance properties like crystallization of cellulose, lignin shield, and interlinking of lignocellulosic biomass is an ideal way to utilize the full-scale potential for biofuel production. This study exhibited three different pretreatment effects to enhance the digestibility of corn s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2786598
更新日期:2016-01-01 00:00:00
abstract::Any bioassay to test new chemically synthesized larvicides or phytolarvicides against Culicidae and more harmful mosquito species, such as Aedes aegypti and Aedes albopictus, which specifically transmit dengue, yellow fever, chikungunya viral fevers as well as Zika virus, or Anopheles gambiae, a vector for malaria and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7405421
更新日期:2020-08-29 00:00:00
abstract:PURPOSE:This study aimed to investigate the shear displacement between the body and backrest/seat, range of motion (ROM), and force acting on the lower limb joints during sit-stand-sit transitions by operating an electric-powered standing wheelchair. METHODS AND MATERIALS:The amounts of sliding along the backrest and ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/236486
更新日期:2014-01-01 00:00:00
abstract:Background:Neighborhood destinations play important roles in daily activity levels of older adults. However, little is known about how specific destinations are associated with these activities and/or sedentary behaviors, especially in Asia. This study investigated how neighborhood destinations were associated with phy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8432934
更新日期:2020-07-30 00:00:00
abstract::Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved du...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/539238
更新日期:2015-01-01 00:00:00
abstract::Little is known about how small variations in ionic currents and Ca²⁺ and Na⁺ diffusion coefficients impact action potential and Ca²⁺ dynamics in rabbit ventricular myocytes. We applied sensitivity analysis to quantify the sensitivity of Shannon et al. model (Biophys. J., 2004) to 5%-10% changes in currents conductanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/565431
更新日期:2013-01-01 00:00:00
abstract::Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3706581
更新日期:2019-11-20 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by variable expressivity, age penetrance, and a high heterogeneity. The transcriptional profile (miRNAs, mRNAs), epigenetic modifications, and posttranslational modifications seem to be highly relevant for the onset of the disease. miRNAs...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/983290
更新日期:2015-01-01 00:00:00
abstract:Purpose:Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9765162
更新日期:2020-02-22 00:00:00
abstract::Contamination of heavy metals would threaten the water and soil resources; phytoremediation can be potentially used to remediate metal contaminated sites. We constructed the Phragmites australis artificial floating wetlands outside the Qingcaosha Reservoir in the Yangtze Estuary. Water characteristic variables were me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6201048
更新日期:2017-01-01 00:00:00
abstract::This study was conducted to determine the effects of feeding oil palm frond silage based diets with added linseed oil (LO) containing high α -linolenic acid (C18:3n-3), namely, high LO (HLO), low LO (LLO), and without LO as the control group (CON) on the fatty acid (FA) composition of subcutaneous adipose tissue and t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/194625
更新日期:2013-01-01 00:00:00
abstract::Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose- or hand-poking, subjects l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/927685
更新日期:2014-01-01 00:00:00
abstract::The regiospecific distribution of fatty acids (FAs) and composition of triglyceride (TAG) molecular species of fishes were analyzed and calculated by pancreatic lipase (PL) hydrolysis and Visual Basic (VB) program. DHA was preferentially located at sn-2 position in TAG molecule, whereas EPA was almost equally distribu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9016840
更新日期:2018-01-29 00:00:00
abstract::The aim of the present paper was to review the most important mechanisms explaining the possible association of vitamin D deficiency and cardiovascular diseases, focusing on recent experimental and clinical data. Low vitamin D levels favor atherosclerosis enabling vascular inflammation, endothelial dysfunction, format...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/109275
更新日期:2015-01-01 00:00:00