Function, Role, and Clinical Application of MicroRNAs in Vascular Aging.

Abstract:

:Vascular aging, a specific type of organic aging, is related to age-dependent changes in the vasculature, including atherosclerotic plaques, arterial stiffness, fibrosis, and increased intimal thickening. Vascular aging could influence the threshold, process, and severity of various cardiovascular diseases, thus making it one of the most important risk factors in the high mortality of cardiovascular diseases. As endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cell biological basis of these pathology changes of the vasculature, the structure and function of ECs and VSMCs play a key role in vascular aging. MicroRNAs (miRNAs), small noncoding RNAs, have been shown to regulate the expression of multiple messenger RNAs (mRNAs) posttranscriptionally, contributing to many crucial aspects of cell biology. Recently, miRNAs with functions associated with aging or aging-related diseases have been studied. In this review, we will summarize the reported role of miRNAs in the process of vascular aging with special emphasis on EC and VSMC functions. In addition, the potential application of miRNAs to clinical practice for the diagnosis and treatment of cardiovascular diseases will also be discussed.

journal_name

Biomed Res Int

authors

Lin X,Zhan JK,Wang YJ,Tan P,Chen YY,Deng HQ,Liu YS

doi

10.1155/2016/6021394

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

6021394

eissn

2314-6133

issn

2314-6141

journal_volume

2016

pub_type

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