Abstract:
:This study aimed to estimate the distribution of hepatitis B virus (HBV) C/D recombinant in Han and Tibet patients with chronic hepatitis B (CHB) and then learn such strain's replication capacity in vivo. A total of 331 serum samples were collected from Han outpatients from Sichuan Province and Tibetan outpatients from Tibet. Viral genotypes in these samples were identified. An HBV replicative plasmid of C/D recombinant was constructed with selected genome. Sequentially, HBV replicative mouse models were established and the replication capacity of the viral strain was studied in vivo. In the 314 Han patients, 66% (207) were infected by genotype B strain while 31% (96) were by genotype C strain. Only 1% (3) were by C/D recombinant. In the 17 Tibetan patients, 41% (7) were by genotype D and 35% (6) by C/D recombinant. A plasmid with 1.3 copies of C/D recombinant genome was constructed. And its replication intermediates were found at similar levels to that of genotype D strain. Thus, C/D recombinant, the dominant viral strain in Tibet, was rather rare in the genotype B predominated Han patients from Sichuan Province. And the C/D recombinant replicated at a similar level to viral strain of genotype D in vivo.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Du L,Liu M,Liu M,Zhou T,Cheng X,Liu C,Tang Hdoi
10.1155/2017/8415907subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8415907eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract:OBJECTIVES:Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be utilized as biomarkers for the noninvasive prenatal diagnosis of chromoso...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/402475
更新日期:2014-01-01 00:00:00
abstract::Three-dimensional (3D) liver tumor segmentation from Computed Tomography (CT) images is a prerequisite for computer-aided diagnosis, treatment planning, and monitoring of liver cancer. Despite many years of research, 3D liver tumor segmentation remains a challenging task. In this paper, an efficient semiautomatic meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5207685
更新日期:2017-01-01 00:00:00
abstract::The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0.5% 4-nitroquinoline-1-oxide (4-NQO) in propylene glycol to tongue, thrice a week for 8 weeks. From 8th to 22nd week, cisplatin (0.23 mg/kg, i.v.) was administere...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/642848
更新日期:2013-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/318364
更新日期:2015-01-01 00:00:00
abstract::WNT proteins are involved in embryonic development, sex determination, stem cell recruitment, angiogenesis, and cancer. They take part in morphological changes in the endometrium during development, regulate processes of endometrial proliferation and differentiation. This review presents current knowledge about implic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/854056
更新日期:2015-01-01 00:00:00
abstract::Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potenti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6456031
更新日期:2016-01-01 00:00:00
abstract::Different opinions exist on the relationship between the C-reactive protein-to-albumin ratio (CAR) and the prognosis of colon cancer. This study is aimed at evaluating the relationship between CAR and prognosis of stage II-III colon cancer and establishing a clinical prognosis model. Patients were randomised to a trai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812974
更新日期:2020-11-22 00:00:00
abstract::Until now, the chemical bonding between titanium and bone has been examined only through a few mechanical detachment tests. Therefore, in this study, a sandblasted and acid-etched titanium mini-implant was removed from a human patient after 2 months of placement in order to identify the chemical integration mechanism ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/960410
更新日期:2015-01-01 00:00:00
abstract::The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis. This study, aimed to investigate whether exosomes originated from bone marrow-derived MSCs (BMSCs) preconditioned by deferoxamine (DFO-Exos)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9742765
更新日期:2019-05-05 00:00:00
abstract:Background:Long noncoding RNAs (lncRNAs) play a crucial role in varieties of biological processes. This study is aimed at investigating meniscal degeneration-specific lncRNAs and mRNAs and their related networks in knee osteoarthritis (KOA). Methods:The dataset GSE98918, which included 24 meniscus samples and related ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123787
更新日期:2020-05-20 00:00:00
abstract:Objective:To investigate the effects of electroacupuncture (EA) at "Zusanli" (ST36) and "Shangjuxu"(ST37) on reducing inflammatory reaction and improving intestinal dysfunction in patients with sepsis-induced intestinal dysfunction with syndrome of obstruction of the bowels Qi. Methods:A total of 71 patients with seps...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/8293594
更新日期:2018-06-26 00:00:00
abstract::Multiple sclerosis (MS) is a central nervous system (CNS) disease resulting from a targeted autoimmune-mediated attack on myelin proteins in the CNS. The release of Th1 inflammatory mediators in the CNS activates macrophages, antibodies, and microglia resulting in myelin damage and the induction of neuropathic pain (N...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/480702
更新日期:2013-01-01 00:00:00
abstract::Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123601
更新日期:2020-09-05 00:00:00
abstract::The number of RNA-Seq studies has grown in recent years. The design of RNA-Seq studies varies from very simple (e.g., two-condition case-control) to very complicated (e.g., time series involving multiple samples at each time point with separate drug treatments). Most of these publically available RNA-Seq studies are d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/318064
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Cost sharing between beneficiaries and government is critical to attain universal health coverage. The government of Ethiopia introduced social health insurance to improve access to quality health services. Hence, HCP are the ultimate frontline service provider; their WTP for health insurance could influence...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8412957
更新日期:2020-04-14 00:00:00
abstract::Toxoplasma gondii (T. gondii) can be transmitted by blood transfusion. We determined the prevalence of T. gondii infection in healthy blood donors in Hermosillo city, Mexico, and the association of infection with T. gondii with the sociodemographic, clinical, and behavioral characteristics of blood donors. Four hundre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9597276
更新日期:2016-01-01 00:00:00
abstract:Background:Methadone Maintenance Treatment (MMT) program's success depends on the likelihood of reducing drop-out rate and keeping patients remaining in the program. There have been neither comprehensive studies about variation among patients who have been experiencing MMT for long period nor prediction of MMT period i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9081968
更新日期:2018-08-07 00:00:00
abstract::Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/143109
更新日期:2015-01-01 00:00:00
abstract::This investigation was aimed at assessing a possible interaction of a traditional Thai herbal recipe, "Ya-Sa-Marn-Phlae (YSMP)," used for wound treatments with topical antiseptics, povidone-iodine (PI) solution and hydrogen peroxide (H2O2), and effects of THR-SK010 alone and the combinations on Staphylococcus aureus. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867603
更新日期:2014-01-01 00:00:00
abstract::Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease (CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the physiological significance of stenotic lesions. A noninvasive "one-stop-...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/435737
更新日期:2015-01-01 00:00:00
abstract::Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/739010
更新日期:2013-01-01 00:00:00
abstract::Each year, hundreds of millions of people travel across international borders or even oceans, and up to 230 million may remain for long periods. Among these, 3-5 million settle permanently in their new homes, with about 1 million migrating permanently to the United States of America. This may result in transport of pa...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/763715
更新日期:2015-01-01 00:00:00
abstract::Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367359
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. AIM:To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC). METHODS:Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/206525
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to evaluate, at a laboratory scale, the ability of this microorganism to grow in seawater and bioaccumulate in mussels (Mytilus galloprovincialis) maintained in constantly aerated tanks, containing twenty litres of artificial seawater. Three concentrations of A. butzleri LMG 10828(T) were tes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/153419
更新日期:2013-01-01 00:00:00
abstract::Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/989175
更新日期:2014-01-01 00:00:00
abstract::Two fullerene derivatives (fullerenes 1 and 2), bearing a hydrophilic chain on the pyrrolidinic nitrogen, were developed with the aim to deliver anticancer agents to solid tumors. These two compounds showed a significantly different behaviour on human neoplastic cell lines in vitro in respect to healthy leukocytes. In...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/915130
更新日期:2015-01-01 00:00:00
abstract::Arrhythmia is a disease that is caused by abnormal electrical activity in the heart rate or rhythm. It is the major cause of cardiovascular morbidity and mortality. Although several antiarrhythmic drugs have been used in clinic for decades, their application is often limited by their adverse effects. As a result, natu...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/4615727
更新日期:2017-01-01 00:00:00
abstract::Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn disease (CD). Similar symptoms, but different treatment procedures for both diseases require precise diagnosis. MicroRNAs (miRNAs) are major posttranscriptional players that regulate the expression of genes during the inflammation and thus co...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4250329
更新日期:2020-07-22 00:00:00
abstract::Acetabular fractures involving predominantly the anterior column associated with a disruption of the quadrilateral surface can be treated with instrumentation implementing the stabilization of the quadrilateral surface. The recently introduced suprapectineal quadrilateral buttress plate is specifically designed to pre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8231301
更新日期:2017-01-01 00:00:00