Abstract:
:This investigation was aimed at assessing a possible interaction of a traditional Thai herbal recipe, "Ya-Sa-Marn-Phlae (YSMP)," used for wound treatments with topical antiseptics, povidone-iodine (PI) solution and hydrogen peroxide (H2O2), and effects of THR-SK010 alone and the combinations on Staphylococcus aureus. Antibacterial activities of ethanol extracts from the herbal recipe were determined against both methicillin resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA). YSMP exhibited remarkable antistaphylococcal activity with MIC values of 3.9-7.8 μg/mL. This recipe possessed bacteriostatic activity and did not reduce the tolerance of both MRSA and MSSA isolates to the high ionic strength. Interaction between THR-SK010 and the antiseptics was carried out by checkerboard testing and time-kill assay. Both indifferent and slightly antagonistic effects were observed with THR-SK010/PI and THR-SK010/H2O2 combinations against the tested isolates. In addition to commercially available antiseptics, THR-SK010 offered additional therapeutic options for the decolonization of MRSA and MSSA. Topical application of plant extracts with antioxidant activity, such as THR-SK010, should not be used immediately with PI or H2O2 and further investigation on this interaction is needed.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chusri S,Tongrod S,Chokpaisarn J,Limsuwan S,Voravuthikunchai SPdoi
10.1155/2014/867603subject
Has Abstractpub_date
2014-01-01 00:00:00pages
867603eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::To overcome the issues connected to the use of autologous vascular grafts and artificial materials for reconstruction of small diameter (<6 mm) blood vessels, this study aimed to develop acellular matrix- (AM-) based vascular grafts. Rat iliac arteries were decellularized by a detergent-enzymatic treatment, whereas en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/685426
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
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更新日期:2019-06-03 00:00:00
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更新日期:2020-01-30 00:00:00
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doi:10.1155/2015/867140
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pub_type: 临床试验,杂志文章,多中心研究
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