Abstract:
:Brain-derived neurotrophic factor (BDNF) has several functions in the central nervous system, where it contributes to brain development and its functionality through affecting neuronal survival and activity and also modulating neurotransmitter levels. This neurotrophin is also found in the serum, but its origin and peripheral function remain unknown. Although the source of circulating BDNF is uncertain, it is stored in platelets and can be released through pharmacological treatment. Decreased levels of BDNF in the serum have been related to the pathophysiology of depression, and this relationship is reinforced by the reversal of this condition by treatment with antidepressants. Recently, riluzole has been proposed for the treatment of depression because it has the ability to lower extracellular glutamate levels and increase BDNF expression; and both mechanisms could be associated with its antidepressant action. Considering that riluzole enhances BDNF levels in the serum of patients, we investigated if treatment with this drug could stimulate the release of this neurotrophin from human platelets obtained from healthy subjects. When platelets were incubated with riluzole for 4 h, the basal value of BDNF (92.9 ± 11.1 pg 10(-6) platelets) was significantly increased (P < 0.05, n = 27). This stimulatory effect was achieved at low concentrations of riluzole (from 10 µM) and was not observed when platelets were incubated with the drug for 24 h. The direct action of riluzole evoking BDNF release from human platelets at therapeutic concentrations is important and may contribute to the understanding of its mechanisms of action in the treatment of depression.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Türck P,Frizzo MEdoi
10.1155/2015/189307subject
Has Abstractpub_date
2015-01-01 00:00:00pages
189307eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/743171
更新日期:2013-01-01 00:00:00
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pub_type: 已发布勘误
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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doi:10.1155/2014/473419
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/7279036
更新日期:2018-07-26 00:00:00
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pub_type: 临床试验,杂志文章
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