Pretreatment Serum Cystatin C Levels Predict Renal Function, but Not Tumor Characteristics, in Patients with Prostate Neoplasia.

Abstract:

:To evaluate the role of Cystatin C (Cys-C) in tumorigenesis and progression of prostate cancer (PCa), we retrospectively collected the clinical information from the records of 492 benign prostatic hyperplasia (BPH), 48 prostatic intraepithelial neoplasia (PIN), and 173 PCa patients, whose disease was newly diagnosed and histologically confirmed. Pretreatment serum Cys-C levels were compared across the various groups and then analyzed to identify relationships, if any, with clinical and pathological characteristics of the PCa patient group. There were no significant differences in serum Cys-C levels among the three groups (P > 0.05). In PCa patients with normal SCr levels, patient age was correlated with serum Cys-C level (P ≤ 0.001) but did not correlate with alkaline phosphatase (AKP), lactate dehydrogenase (LDH), prostate specific antigen (PSA), Gleason score, or bone metastasis status (P > 0.05). Age and SCr contributed in part to the variations in serum Cys-C levels of PCa patients (r = 0.356, P ≤ 0.001; r = 0.520, P ≤ 0.001). In conclusion, serum Cys-C levels predict renal function in patients with prostate neoplasia, but were not a biomarker for the development of prostate neoplasia, and were not correlated with the clinicopathological characteristics of PCa.

journal_name

Biomed Res Int

authors

Yang F,Li D,Di Y,Zhang Y,Zang Y,Ren J,Yan L,Zhou Z,Liu H,Xu Z

doi

10.1155/2017/7450459

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

7450459

eissn

2314-6133

issn

2314-6141

journal_volume

2017

pub_type

杂志文章
  • Circulating Exosomal miRNAs as Novel Biomarkers for Stable Coronary Artery Disease.

    abstract::Exosomal miRNAs are currently being explored as a novel class of biomarkers in cardiovascular diseases. However, few reports have focused on the value of circulating exosomal miRNAs as biomarkers for stable coronary artery disease (SCAD). Here, we aimed to investigate whether miRNAs involved in cardiovascular diseases...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3593962

    authors: Zhang P,Liang T,Chen Y,Wang X,Wu T,Xie Z,Luo J,Yu Y,Yu H

    更新日期:2020-12-11 00:00:00

  • Classification of Hallucal Sesamoid Bone Correlated with Hallux Valgus Severity.

    abstract::The hallucal sesamoid bones (HSBs), having an important role in reducing load per unit area on the first metatarsal head, can be injured commonly which also affected the first metatarsophalangeal joint and the surrounding structure. Meanwhile, differences among each HSB type may be a major factor affecting the occurre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9658916

    authors: Zhang L,Wang J,Liu J,Luo J

    更新日期:2020-06-26 00:00:00

  • The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients.

    abstract:BACKGROUND:This study investigated whether the 1 : 2 ω-3/ω-6 ratio may reduce proinflammatory response in human alveolar cells (A549) exposed to an ex vivo inflammatory stimulus (bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients). Methods. We exposed A549 cells to the BALF colle...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/642520

    authors: Cotogni P,Trombetta A,Muzio G,Maggiora M,Canuto RA

    更新日期:2015-01-01 00:00:00

  • Systematic analysis of the associations between adverse drug reactions and pathways.

    abstract::Adverse drug reactions (ADRs) are responsible for drug candidate failure during clinical trials. It is crucial to investigate biological pathways contributing to ADRs. Here, we applied a large-scale analysis to identify overrepresented ADR-pathway combinations through merging clinical phenotypic data, biological pathw...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/670949

    authors: Chen X,Wang Y,Wang P,Lian B,Li C,Wang J,Li X,Jiang W

    更新日期:2015-01-01 00:00:00

  • Comprehensive Identification of Potential Crucial Genes and miRNA-mRNA Regulatory Networks in Papillary Thyroid Cancer.

    abstract:Background:Thyroid cancer is the most common endocrine malignancy, with a recent global increase of 20% in age-related incidence. Ultrasonography and ultrasonography-guided fine-needle aspiration biopsy (FNAB) are the most widely used diagnostic tests for thyroid nodules; however, it is estimated that up to 25% of thyr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2021/6752141

    authors: Nan BY,Xiong GF,Zhao ZR,Gu X,Huang XS

    更新日期:2021-01-12 00:00:00

  • Facial vibrotactile stimulation activates the parasympathetic nervous system: study of salivary secretion, heart rate, pupillary reflex, and functional near-infrared spectroscopy activity.

    abstract::We previously found that the greatest salivation response in healthy human subjects is produced by facial vibrotactile stimulation of 89 Hz frequency with 1.9 μ m amplitude (89 Hz-S), as reported by Hiraba et al. (2012, 20011, and 2008). We assessed relationships between the blood flow to brain via functional near-inf...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/910812

    authors: Hiraba H,Inoue M,Gora K,Sato T,Nishimura S,Yamaoka M,Kumakura A,Ono S,Wakasa H,Nakayama E,Abe K,Ueda K

    更新日期:2014-01-01 00:00:00

  • Predominance of Abdominal Visceral Adipose Tissue Reflects the Presence of Aortic Valve Calcification.

    abstract::Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2174657

    authors: Oikawa M,Owada T,Yamauchi H,Misaka T,Machii H,Yamaki T,Sugimoto K,Kunii H,Nakazato K,Suzuki H,Saitoh S,Takeishi Y

    更新日期:2016-01-01 00:00:00

  • The relationship between Helicobacter pylori and beta-2 microglobulin in humans.

    abstract:UNLABELLED:H. pylori is related to various gastrointestinal diseases. β₂ Microglobulin (β 2M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β₂M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β₂M and H. pylori bearing CagA strains....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/615089

    authors: Yeniova AÖ,Kucukazman M,Ata N,Dal K,Kefeli A,Başyiğit S,Aktaş B,Akın KO,Nazlıgül Y

    更新日期:2014-01-01 00:00:00

  • Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants.

    abstract:Objective:ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1892458

    authors: Xia X,Ren Z,Yan L,Zheng X,Yang H,Kang M,Yan H,Zhong Z,Xu F,Miao J,Wang J,Li Y,Wei W,Yang J

    更新日期:2020-11-27 00:00:00

  • Effects of Bee Venom Injections at Acupoints on Neurologic Dysfunction Induced by Thoracolumbar Intervertebral Disc Disorders in Canines: A Randomized, Controlled Prospective Study.

    abstract::Intervertebral disk disease (IVDD) is a major spine disorder in canines that causes neurological dysfunction, particularly in the thoracolumbar area. Analgesic and anti-inflammatory drugs are typically used to reduce nociceptive signals to decrease canine suffering. Bee venom (BV) has been reported to exert anti-infla...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/363801

    authors: Tsai LC,Lin YW,Hsieh CL

    更新日期:2015-01-01 00:00:00

  • Weaker Self-Esteem in Adolescence Predicts Smoking.

    abstract:BACKGROUND:To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. METHODS:An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 (n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/687541

    authors: Saari AJ,Kentala J,Mattila KJ

    更新日期:2015-01-01 00:00:00

  • Mediterranean spotted fever in southeastern Romania.

    abstract::Although cases of Mediterranean spotted fever (MSF) have been reported for decades in southeastern Romania, there are few published data. We retrospectively studied 339 patients, diagnosed with MSF at the National Institute of Infectious Diseases "Prof. Dr. Matei Bals" between 2000 and 2011, in order to raise awarenes...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/395806

    authors: Pitigoi D,Olaru ID,Badescu D,Rafila A,Arama V,Hristea A

    更新日期:2013-01-01 00:00:00

  • Effects of Propranolol on Neurodevelopmental Outcomes in Patients with Infantile Hemangioma: A Case-Control Study.

    abstract:Background:The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods:Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy childr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5821369

    authors: Wang C,Wang Q,Xiang B,Chen S,Xiong F,Ji Y

    更新日期:2018-02-25 00:00:00

  • Morphometric and statistical analysis of the palmaris longus muscle in human and non-human primates.

    abstract::The palmaris longus is considered a phylogenetic degenerate metacarpophalangeal joint flexor muscle in humans, a small vestigial forearm muscle; it is the most variable muscle in humans, showing variation in position, duplication, slips and could be reverted. It is frequently studied in papers about human anatomical v...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/178906

    authors: Aversi-Ferreira RA,Bretas RV,Maior RS,Davaasuren M,Paraguassú-Chaves CA,Nishijo H,Aversi-Ferreira TA

    更新日期:2014-01-01 00:00:00

  • A Comparison of Surgical Invasions for Spinal Nerve Ligation with or without Paraspinal Muscle Removal in a Rat Neuropathic Pain Model.

    abstract::L5 spinal nerve ligation (SNL) in rats is one of the most popular models for studying neuropathic pain because of its high reproducibility. During the surgery, a part of the L5 paraspinal muscle is usually removed, which produces extra trauma and may potentially affect the physiological processes involved in neuropath...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6741295

    authors: Huang YG,Zhang Q,Wu H,Zhang CQ

    更新日期:2016-01-01 00:00:00

  • A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury.

    abstract::Traumatic brain injury (TBI) is a critical public health and socioeconomic problem worldwide. The herb pair Astragali Radix (AR)-Radix Angelica Sinensis (RAS) is a common prescribed herbal formula or is added to other Chinese medicine prescriptions for traumatic brain injury (TBI) treatment. However, the underlying me...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3951783

    authors: Xie G,Peng W,Li P,Xia Z,Zhong Y,He F,Tulake Y,Feng D,Wang Y,Xing Z

    更新日期:2018-11-25 00:00:00

  • Comparison of Clinical Outcomes of Two-Level PELD and Foraminoplasty PELD for Highly Migrated Disc Herniations: A Comparative Study.

    abstract:Objective:The aim of this study is to compare the clinical outcomes of two-level percutaneous endoscopic lumbar discectomy (PELD) and foraminoplasty PELD in treating highly migrated lumbar disc herniations. Methods:Patients with highly migrated lumbar disc herniations were enrolled from May 2014 to June 2016. Low back...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9681424

    authors: Wu X,Fan G,He S,Gu X,Yang Y

    更新日期:2019-10-13 00:00:00

  • Relationship Between Emotional Intelligence and Health Behaviours among University Students: The Predictive and Moderating Role of Gender.

    abstract::This study investigated the role of gender as a potential predictor of health behaviour and potential moderator of the relationship between emotional intelligence and health behaviour. This cross-sectional study included 1214 students (597 males and 617 females). Data were collected using the Schutte Self-Report Inven...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7058105

    authors: Malinauskas R,Dumciene A,Sipaviciene S,Malinauskiene V

    更新日期:2018-06-04 00:00:00

  • Esculetin Neutralises Cytotoxicity of t-BHP but Not of H2O2 on Human Leukaemia NB4 Cells.

    abstract::The coumarin esculetin shows antioxidant action on some cell types, both by scavenging ROS and by decreasing ROS production. We have previously demonstrated the induction of apoptosis by esculetin on NB4 human leukaemia cells by an ill-defined mechanism related to ROS levels. In this work, we analyze the effect of the...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/9491045

    authors: Rubio V,García-Pérez AI,Tejedor MC,Herráez A,Diez JC

    更新日期:2017-01-01 00:00:00

  • A Review of Ginseng Clinical Trials Registered in the WHO International Clinical Trials Registry Platform.

    abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/1843142

    authors: He Y,Yang J,Lv Y,Chen J,Yin F,Huang J,Zheng Q

    更新日期:2018-02-06 00:00:00

  • Factors Influencing Administration, Recognition, and Compliance of Medicine among Community Residents from Jilin Province, China: A Questionnaire Study.

    abstract:Introduction:To identify and analyze factors that influence administration, recognition, and compliance of medicine among community residents in Jilin Province, China. Methods:A survey was carried out among 2417 community residents in Jilin Province, China, to study their administration (CRA), recognition (CRR), and c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8730212

    authors: Song YQ,Zhang WR,Zhang SX,Wang TH,Jiang Z,Meng CF,Zhang TZ,Xin QZ,Cao KJ,Zhang Y,Sun Y

    更新日期:2020-07-18 00:00:00

  • Acid lipase from Candida viswanathii: production, biochemical properties, and potential application.

    abstract::Influences of environmental variables and emulsifiers on lipase production of a Candida viswanathii strain were investigated. The highest lipase activity (101.1 U) was observed at 210 rpm, pH 6.0, and 27.5°C. Other fermentation parameters analyzed showed considerable rates of biomass yield (Y L/S = 1.381 g/g), lipase ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/435818

    authors: de Almeida AF,Tauk-Tornisielo SM,Carmona EC

    更新日期:2013-01-01 00:00:00

  • Differences in extended-spectrum beta-lactamase producing Escherichia coli virulence factor genes in the Baltic Sea region.

    abstract::The aim of this study was to compare the prevalence of different virulence factor (VF) genes in extended-spectrum beta-lactamase (ESBL) producing Escherichia coli strains isolated from the Baltic Sea region. A total of 432 strains of phenotypically ESBL positive E. coli were collected from 20 institutions located in E...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/427254

    authors: Lillo J,Pai K,Balode A,Makarova M,Huik K,Kõljalg S,Ivanova M,Kaftyreva L,Miciuleviciene J,Naaber P,Parv K,Pavelkovich A,Rööp T,Toompere K,Suzhaeva L,Sepp E

    更新日期:2014-01-01 00:00:00

  • Effect of nanoparticles and environmental particles on a cocultures model of the air-blood barrier.

    abstract::Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effect...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/801214

    authors: Bengalli R,Mantecca P,Camatini M,Gualtieri M

    更新日期:2013-01-01 00:00:00

  • A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage.

    abstract::The objective of this study was to investigate the effects of selective inducible nitric oxide synthase and neuronal nitric oxide synthase inhibitors on cartilage regeneration. The study involved 27 Wistar rats that were divided into five groups. On Day 1, both knees of 3 rats were resected and placed in a formalin so...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7857345

    authors: Gokay NS,Yilmaz I,Komur B,Demiroz AS,Gokce A,Dervisoglu S,Gokay BV

    更新日期:2016-01-01 00:00:00

  • Highlight on advances in nontuberculous mycobacterial disease in North America.

    abstract::Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and exist as an important cause of pulmonary infections in humans. Pulmonary involvement is the most common disease manifestation of NTM and the incidence of NTM is growing in North America. Susceptibility to NTM infection is incompletely understood; ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/919474

    authors: Mirsaeidi M,Farshidpour M,Allen MB,Ebrahimi G,Falkinham JO

    更新日期:2014-01-01 00:00:00

  • Association analysis between g.18873C>T and g.27522G>A genetic polymorphisms of OPG and bone mineral density in Chinese postmenopausal women.

    abstract::Several studies report that the OPG is an important candidate gene in the pathogenesis of osteoporosis. This study aimed to detect the potential association of OPG gene polymorphisms with osteoporosis in postmenopausal women. We recruited 928 subjects containing 463 with primary postmenopausal osteoporosis and 465 hea...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/320828

    authors: Wang F,Cao Y,Li F,Shan J,Wen T

    更新日期:2014-01-01 00:00:00

  • Short-Term Results Suggest That Sleeved Stomach without Resection Is as Effective as Sleeve Gastrectomy in Improving Glucose Control in Type 2 Diabetes Mellitus Sprague-Dawley Rat Model.

    abstract:Background:Although sleeve gastrectomy results in good weight loss and metabolic improvements, it is an irreversible procedure. Therefore, we attempted to assess the possibility of creating a sleeved stomach without resection. Material and Methods. A total of 22 male Sprague-Dawley rats with type 2 diabetes were random...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9024923

    authors: Zhang W,Widjaja J,Yao L,Shao Y,Zhu X,Li C

    更新日期:2020-05-01 00:00:00

  • Pathogenesis of renal failure in multiple myeloma: any role of contrast media?

    abstract::The spectrum of kidney disease-associated monoclonal immunoglobulin and plasma cell malignancies is remarkably broad and encompasses nearly all nephropathologic entities. Multiple myeloma with kidney impairment at presentation is a medical emergency since the recovery of kidney function is associated with survival ben...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/167125

    authors: Mussap M,Merlini G

    更新日期:2014-01-01 00:00:00

  • Shock absorbing function study on denucleated intervertebral disc with or without hydrogel injection through static and dynamic biomechanical tests in vitro.

    abstract::Hydrogel injection has been recently proposed as a novel therapy for disc degenerative diseases, with the potential to restore the spine motion and the intervertebral disc height. However, it remains unknown whether the new technique could also maintain the shock absorbing property of the treated intervertebral disc. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/461724

    authors: Zhou Z,Gao M,Wei F,Liang J,Deng W,Dai X,Zhou G,Zou X

    更新日期:2014-01-01 00:00:00