Abstract:
:The coumarin esculetin shows antioxidant action on some cell types, both by scavenging ROS and by decreasing ROS production. We have previously demonstrated the induction of apoptosis by esculetin on NB4 human leukaemia cells by an ill-defined mechanism related to ROS levels. In this work, we analyze the effect of the simultaneous treatment with esculetin and two oxidants to observe the early events in the mechanism of esculetin-induced apoptosis. Our results show that, from the early time of 15 min, esculetin acts synergistically with H2O2 to decrease cell viability and metabolic activity and to increase apoptosis in NB4 cells. In contrast, the early oxidative effects of t-BHP are neutralised by esculetin, protecting human leukaemia NB4 cells from apoptosis. Esculetin seems to restrict the increase in peroxides caused by H2O2 or t-BHP in the time interval analyzed. These results contribute to a better understanding of the cytotoxic effect caused by esculetin on NB4 cells. At the same time, the early neutralisation of exogenous oxidants could be of interest to prevent diseases related to oxidative stress imbalance.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Rubio V,García-Pérez AI,Tejedor MC,Herráez A,Diez JCdoi
10.1155/2017/9491045subject
Has Abstractpub_date
2017-01-01 00:00:00pages
9491045eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Pulmonary arterial hypertension (PAH) is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Growth factors, cytokines, and lipid mediators are involved in this remodeling process. Recent reports suggest that the peroxisome proliferator-activated receptors (PPARs) play important ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/903947
更新日期:2013-01-01 00:00:00
abstract::Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia. It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation. The solution was modified by the addition of ascorbic acid (0.088g/l) and ascorbic ac...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7465435
更新日期:2018-11-12 00:00:00
abstract::CA-125 has been a valuable marker for the follow-up of ovarian cancer patients but it is not sensitive enough to be used as diagnostic marker. We had already used secretomic methods to identify proteins differentially secreted by serous ovarian cancer cells compared to healthy ovarian cells. Here, we evaluated the sec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/208017
更新日期:2015-01-01 00:00:00
abstract::Slaughterhouse work involves a high degree of repetitive and forceful upper limb movements and thus implies an elevated risk of work-related musculoskeletal disorders. High intensity strength training effectively rehabilitates musculoskeletal disorders among sedentary employees, but less is known about the effect amon...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/218546
更新日期:2014-01-01 00:00:00
abstract::Application of enzymes in biotechnological process has expanded considerably in recent years. In food and related industry, major importance was being attached to the use of enzymes in upgrading quality, increasing yields of extractive processes, product stabilization, and improvement of flavor and byproduct utilizati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2961767
更新日期:2018-04-03 00:00:00
abstract::The knowledge on the genetic etiology of complex disorders largely results from the study of rare monogenic disorders. Often these common and rare diseases show phenotypic overlap, though monogenic diseases generally have a more extreme symptomatology. ABCC6, the gene responsible for pseudoxanthoma elasticum, an autos...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/648569
更新日期:2015-01-01 00:00:00
abstract::(124)Iodine ((124)I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of (124)I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecul...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/672094
更新日期:2014-01-01 00:00:00
abstract::Chagas disease is caused by Trypanosoma cruzi infection. Besides the host-related factors, such as immune response and genetic background, the parasite, strain, and occurrences of reinfection episodes, may influence disease outcome. Our results demonstrate that both the primary infection and the reinfection with the C...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/648715
更新日期:2014-01-01 00:00:00
abstract::Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of muscle mass and strength. The more rationale approach to delay the progression of sarcopenia is based on the combination of proper nutrition, possibly associated with the use of dietary supplements and a regular exercise program. ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/524948
更新日期:2015-01-01 00:00:00
abstract::The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high-incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin-embedded esophageal tissues and 152 paraffin-embedd...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7926754
更新日期:2020-12-02 00:00:00
abstract::We measured 28 parameters of 202 femurs from Koreans by an automated geometric computation program using 3D models generated from computed tomography images. The measurement parameters were selected with reference to physical and forensic anthropology studies as well as orthopedic implant design studies. All measureme...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/730538
更新日期:2015-01-01 00:00:00
abstract::A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/743812
更新日期:2014-01-01 00:00:00
abstract::We compared the performances of 3 Multiple Allergen Simultaneous Test (MAST) assays: RIDA Allergy Screen (R-Biopharm, Darmstadt, Germany), MAST Optigen allergy system (Hitachi Chemical Diagnostics, Mountain View, CA), and Polycheck Allergy (Biocheck GmbH, Munster, Germany). Forty sera that tested positive with the RID...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/340513
更新日期:2013-01-01 00:00:00
abstract:Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6762029
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:Novel prognostic markers are needed so newly diagnosed breast cancer patients do not undergo any unnecessary therapy. Various microarray gene expression datasets based studies have generated gene signatures to predict the prognosis outcomes, while ignoring the large amount of information contained in establi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/459203
更新日期:2014-01-01 00:00:00
abstract::Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6416941
更新日期:2019-06-11 00:00:00
abstract::Introduction. Given its efficacy and safety, NexoBrid™ (NXB) has become part of our therapeutic options in burns treatment with satisfactory results. However, no cost analysis comparing NXB to the standard of care (SOC) has been carried out as of today. Aim. To assess the cost of treatment with NXB and compare it to t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9567498
更新日期:2017-01-01 00:00:00
abstract::Objectives. To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD). Methods. A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled. The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4013685
更新日期:2017-01-01 00:00:00
abstract::Aldosterone synthase (CYP11B2) is a key enzyme for the biosynthesis of aldosterone, which plays a significant role for the regulation of blood pressure. Excess aldosterone can cause the dysregulation of the renin-angiotensin-aldosterone system (RAAS) and lead to hypertension. Therefore, research and development of CYP...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4182595
更新日期:2016-01-01 00:00:00
abstract::A reliable in vivo imaging method to localize transplanted cells and monitor their viability would enable a systematic investigation of cell therapy. Most stem cell transplantation studies have used immunohistological staining, which does not provide information about the migration of transplanted cells in vivo in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/231805
更新日期:2015-01-01 00:00:00
abstract::MicroRNAs are small noncoding RNAs, involved in the regulation of many cellular processes in plants. Hundreds of miRNAs have been identified in cassava by various techniques, yet these identifications were constrained by a lack of miRNA templates and the narrow range of conditions in transcriptome study. In this resea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2019846
更新日期:2019-06-19 00:00:00
abstract::Nickel-titanium (NiTi) rotary files have enabled efficient root canal preparations that maintain the canal center with fewer aberrations compared to hand files. However, NiTi rotary files are susceptible to fracture, which can thereby compromise root canal treatment. Therefore, NiTi files have been developed to enhanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6368958
更新日期:2019-11-07 00:00:00
abstract::In a bioprospecting effort towards novel thermostable lipases, we assessed the lipolytic profile of 101 bacterial strains isolated from the volcanic area of Santorini, Aegean Sea, Greece. Screening of lipase activity was performed both in agar plates and liquid cultures using olive oil as carbon source. Significant di...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/703130
更新日期:2013-01-01 00:00:00
abstract::The Toll-Like receptor 4 (TLR4) plays an important role in immunity, tissue repair, and regeneration. The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/318686
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Long-term survival of total knee arthroplasty (TKA) is mainly determined by optimal positioning of the components and prosthesis alignment. Implant positioning can be optimized by computer assisted surgery (CAS). Patient specific cutting blocks (PSCB) seem to have the potential to improve component alignment...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/562919
更新日期:2014-01-01 00:00:00
abstract::Newcastle disease (ND) is one of the most devastating diseases that considerably cripple the global poultry industry. Because of its enormous socioeconomic importance and potential to rapidly spread to naïve birds in the vicinity, ND is included among the list of avian diseases that must be notified to the OIE immedia...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/7278459
更新日期:2018-08-05 00:00:00
abstract:Objective:Hepatitis B virus (HBV) causes inflammation of the liver and is the leading cause of both liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Serine protease inhibitor Kazal type 1 (SPINK1) is an acute-phase response protein that is overexpressed in liver cancer tissue. This study investigated the clinic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9321494
更新日期:2019-05-22 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal condition primarily characterized by the selective loss of upper and lower motor neurons. At present, the diagnosis and monitoring of ALS is based on clinical examination, electrophysiological findings, medical history, and exclusion of confounding disorders. There is the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/525097
更新日期:2014-01-01 00:00:00
abstract:Background:Open laminectomy has been regarded as the standard surgical procedure for lumbar lateral recess stenosis during the last decades. Although percutaneous endoscopic lumbar decompression has led to successful results comparable with open decompression, its application in LSS with is still challenging and techni...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2601232
更新日期:2018-11-26 00:00:00
abstract::Schwannomas are the commonest tumours of peripheral nerves. Despite the classical description that schwannomas are well encapsulated and can be completely enucleated during excision, a portion of them have fascicular involvement and could not be completely shelled out. A retrospective review for 8 patients was carried...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/167196
更新日期:2013-01-01 00:00:00