Abstract:
:(124)Iodine ((124)I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of (124)I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecules and larger compounds like proteins and antibodies have been successfully labeled with (124)I. Advances in radionuclide production allow the effective availability of sufficient quantities of (124)I on small biomedical cyclotrons for molecular imaging purposes. Radioiodination chemistry with (124)I relies on well-established radioiodine labeling methods, which consists mainly in nucleophilic and electrophilic substitution reactions. The physical characteristics of (124)I permit taking advantages of the higher PET image quality. The availability of new molecules that may be targeted with (124)I represents one of the more interesting reasons for the attention in nuclear medicine. We aim to discuss all iodine radioisotopes application focusing on (124)I, which seems to be the most promising for its half-life, radiation emissions, and stability, allowing several applications in oncological and nononcological fields.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cascini GL,Niccoli Asabella A,Notaristefano A,Restuccia A,Ferrari C,Rubini D,Altini C,Rubini Gdoi
10.1155/2014/672094subject
Has Abstractpub_date
2014-01-01 00:00:00pages
672094eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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