Abstract:
:Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia. It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation. The solution was modified by the addition of ascorbic acid (0.088g/l) and ascorbic acid with prolactin (1 μg/l PRL + 0.088g/l vitamin C). The effectiveness of the obtained solutions in the protection of nephrons of isolated porcine kidneys was assessed based on the analysis of the activity of ALT (alanine aminotransferase), AST (aspartate aminotransferase), and LDH (lactate dehydrogenase) as well as lactate concentration determined in perfundates collected after 2 h (0' and 30' preservation) and 48 h (0' and 30' preservation) of graft storage. It has been found that the synergistic action of Biolasol components determines the integrity and stability of cell membranes, which in turn affects the proper functioning of the organ after transplantation. The addition of ascorbic acid and prolactin to Biolasol affects the maintenance of the normal cytoskeleton of the stored graft.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Ostróżka-Cieślik A,Dolińska B,Ryszka Fdoi
10.1155/2018/7465435subject
Has Abstractpub_date
2018-11-12 00:00:00pages
7465435eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
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