Abstract:
:Pulmonary arterial hypertension (PAH) is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Growth factors, cytokines, and lipid mediators are involved in this remodeling process. Recent reports suggest that the peroxisome proliferator-activated receptors (PPARs) play important roles in the regulation of cell growth and differentiation as well as tissue wounding and repair. In this study, we examined the role of PPAR δ in the regulation of proliferation, migration, collagen synthesis, and chemokine production in human pulmonary arterial smooth muscle cells (HPASMCs). The data showed that PPAR δ was the most abundant isoform in HPASMCs. PPAR δ was upregulated in HPASMCs treated with PDGF, which is the major mediator in pulmonary vascular remodeling. Activation of PPAR δ by GW501516, a specific PPAR δ ligand, significantly inhibited PDGF-induced proliferation in HPASMCs. The inhibitory effect of GW501516 on HPASMCs was associated with decreased expression of cyclin D1, cyclin D3, CDK2, and CDK4 as well as increased expression of the cell cycle inhibitory genes G0S2 and P27(kip1). Pretreatment of HPASMCs with GW501516 significantly inhibited PDGF-induced cell migration and collagen synthesis. GW501516 also significantly attenuated TNF-mediated expression of MCP-1. These results suggest that PPAR δ may be a potential therapeutic target against the progression of vascular remodeling in PAH.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Liu G,Li X,Li Y,Tang X,Xu J,Li R,Hao P,Sun Ydoi
10.1155/2013/903947subject
Has Abstractpub_date
2013-01-01 00:00:00pages
903947eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract:Background:Pakistan is a country with one of the highest burden of tuberculosis (TB) in the world, and therefore, it is imperative to revisit the design of behaviour change interventions in the program. This study was designed to understand and assess the knowledge, awareness, perceptions, and health-seeking behaviour ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1850541
更新日期:2020-04-21 00:00:00
abstract::J-proteins are molecular chaperones and present in a wide variety of organisms from prokaryote to eukaryote. Based on their domain organizations, J-proteins can be classified into 4 types, that is, Type I, Type II, Type III, and Type IV. Different types of J-proteins play distinct roles in influencing cancer propertie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/935719
更新日期:2014-01-01 00:00:00
abstract::Aims. We describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify and compare simultaneously global methylation and hydroxymethylation in human DNA of different tissues. Materials and Methods. Blood and saliva DNA from fourteen volunteers was processed for epigenetic endpoints using LC-M...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/845041
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Firstly, to, through instrumentation with the iPhone4 smartphone, measure and describe variability of tridimensional acceleration, angular velocity, and displacement of the trunk in the turn transition during the ten-meter Extended Timed-Get-up-and-Go test in two groups of frail and physically active elderly ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/279197
更新日期:2013-01-01 00:00:00
abstract::Arthritogenic alphaviruses, including Ross River virus (RRV), Chikungunya virus (CHIKV), Sindbis virus (SINV), Mayaro virus (MAYV), O'nyong-nyong virus (ONNV), and Barmah Forest virus (BFV), cause incapacitating and long lasting articular disease/myalgia. Outbreaks of viral arthritis and the global distribution of the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/973516
更新日期:2013-01-01 00:00:00
abstract:Background:A multifactorial decision support system (mDSS) is a tool designed to improve the clinical decision-making process, while using clinical inputs for an individual patient to generate case-specific advice. The study provides an overview of the literature to analyze current available mDSS focused on prostate ca...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/4961768
更新日期:2019-06-06 00:00:00
abstract:PURPOSE:This study aimed to investigate the shear displacement between the body and backrest/seat, range of motion (ROM), and force acting on the lower limb joints during sit-stand-sit transitions by operating an electric-powered standing wheelchair. METHODS AND MATERIALS:The amounts of sliding along the backrest and ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/236486
更新日期:2014-01-01 00:00:00
abstract:Objective:ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1892458
更新日期:2020-11-27 00:00:00
abstract:OBJECTIVE:Conventional surgical techniques of laryngomicrosurgery (LMS) on hemorrhagic vocal polyps are often difficult due to obscuration of the surgical field by inadvertent bleeding from the lesion, and there are often significant amounts of mucosal epithelium loss. Here, we introduce our surgical technique using pu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/820654
更新日期:2015-01-01 00:00:00
abstract::The endoscopic and histopathological findings detected in Sparus aurata experimentally infected with third-stage Anisakis larvae without intermediate host are evaluated and discussed. In six fish, live nematode larvae were introduced by gastroscopy into the stomach. The first observation by endoscope, 15 days after ch...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/701828
更新日期:2013-01-01 00:00:00
abstract::Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/256580
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was the synthesis of folic acid- (FA-) targeted polymeric micelles of Synperonic PE/F 127-cholesteryl hemisuccinate (PF127-Chol) for specific delivery of docetaxel (DTX). Targeted or nontargeted micelles loaded with DTX were prepared via dialysis method. The effects of processing variables ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/746093
更新日期:2015-01-01 00:00:00
abstract::This study compared the coadministration among the three nematode predatory fungi, Duddingtonia flagrans, Monacrosporium thaumasium, and Arthrobotrys robusta, in the biological control of cattle gastrointestinal nematodiasis in comparison with the use of the fungus D. flagrans alone. Five groups consisting of eight Gi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2934674
更新日期:2018-03-26 00:00:00
abstract::Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expressi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/432479
更新日期:2015-01-01 00:00:00
abstract::Aim. The aim of the study was to compare the incidence of "de novo" overactive bladder (OAB) after sling surgeries and Burch procedure and to analyze the effect of the preoperative bladder volume on the incidence of this condition. Methods. This prospective trial included 290 female patients with stress urinary incont...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9515242
更新日期:2019-02-12 00:00:00
abstract::Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5281251
更新日期:2020-03-23 00:00:00
abstract::The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controve...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3571861
更新日期:2017-01-01 00:00:00
abstract::Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified. Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients. Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 te...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2568301
更新日期:2016-01-01 00:00:00
abstract::Densitometry data generated for Western blots are commonly used to compare protein abundance between samples. In the last decade, it has become apparent that assumptions underpinning these comparisons are often violated in studies reporting Western blot data in the literature. These violations can lead to erroneous in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5214821
更新日期:2019-01-21 00:00:00
abstract:Aim:The aim of this study is to detect the prevalence of substance use among tenth-grade students; their thoughts, attitudes, behaviors, and tendencies towards substance use; and risk factors of substance use in tenth-grade students in general. Methods:This study is descriptive and cross-sectional conducted between Ap...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1407649
更新日期:2018-03-15 00:00:00
abstract::Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism impairment. MicroRNAs are implicated in the development of heart failure. However, the mitochondria enriched microRNA during heart failure remains elusive. Here, we generated a pressure overload-induced early and late stage heart fai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4042509
更新日期:2017-01-01 00:00:00
abstract::Understanding the mechanism behind the structure of the internal cellular clock can lead to advances in the knowledge of origins of pairs of monozygotic twins and higher order multiples as well as other biological phenomena. To gain insight into this mechanism, we analyze possible cell labeling schemes that model an o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/628092
更新日期:2015-01-01 00:00:00
abstract:Background:The incidence of osteoporotic fractures is increasing. In this study, we explored the activities of Wnt/β-catenin signaling in bone tissues with iron accumulation. Methods:We established rat bipedal walking models (RBWM), and a portion of our RBWM rats were intraperitoneally injected with ferric ammonium ci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8256261
更新日期:2020-05-24 00:00:00
abstract::To protect against the environmental pollution, the present research was undertaken to enumerate the Bacterial Technologies (BTs) on the restoration of polluted urban rivers, that is, Fenghu-Song Yang River (FSR) and Xuxi River (XXR). Experimental research accounted for the physiochemical parameters (pH; temperature; ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/241769
更新日期:2015-01-01 00:00:00
abstract::Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to asept...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3687415
更新日期:2018-06-05 00:00:00
abstract:OBJECTIVE:To investigate the relationship of delivery type, maternal anesthesia, feeding modalities, and first feeding and meconium passage times with early bilirubin levels of healthy infants. METHODS:Cord, 24 hours' and 48 hours' total bilirubin levels were measured in 388 study infants. RESULTS:Infants born with c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/316430
更新日期:2013-01-01 00:00:00
abstract::Background and Aims. CIN is a major and serious complication following PCI in patients with ACS. It is unclear whether a higher serum ferritin level is associated with an increased risk of CIN in high-risk patients. Thus, we conducted this study to assess the predictive value of SF for the risk of CIN after PCI. Metho...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5420345
更新日期:2016-01-01 00:00:00
abstract::The objective of the current research was to review and update evidence on the dietary effect of the consumption of tagatose in type 2 diabetes, as well as to elucidate the current approach that exists on its production and biotechnological utility in functional food for diabetics. Articles published before July 1, 20...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/8718053
更新日期:2018-01-09 00:00:00
abstract:Objective:The aim of this study is to explore the potential pathogenesis of juvenile dermatomyositis by bioinformatics analysis of gene chips, which would screen the hub genes, identify potential biomarkers, and reveal the development mechanism of juvenile dermatomyositis. Material and Methods:We retrieved juvenile de...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7814287
更新日期:2019-12-07 00:00:00
abstract::Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9204708
更新日期:2020-01-23 00:00:00