Abstract:
:To establish a reliable isoproterenol induced heart dysfunction fetal rat model and understand the switches of contractile proteins, 45 pregnant rats were divided into 15 mg/kg-once, 15 mg/kg-twice, sham-operated once, sham-operated twice, and control groups. And 18 adult rats were divided into isoproterenol-treated and control groups. H&E staining, Masson staining, and transmission electron microscope were performed. Apoptotic rate assessed by TUNEL analysis and expressions of ANP, BNP, MMP-2, and CTGF of hearts were measured. Intra-amniotic injections of isoproterenol were supplied on E14.5 and E15.5 for fetuses and 7-day continuous intraperitoneal injections were performed for adults. Then echocardiography was performed with M-mode view assessment on E18.5 and 6 weeks later, respectively. Isoproterenol twice treated fetuses exhibited significant changes in histological evaluation, and mitochondrial damages were significantly severe with increased apoptotic rate. ANP and BNP increased and that of MMP-2 increased in isoproterenol twice treated group compared to control group, without CTGF. The isoforms transition of troponin I and myosin heavy chain of fetal heart dysfunction were opposite to adult procedure. The administration of intra-amniotic isoproterenol to fetal rats could induce heart dysfunction and the regulation of contractile proteins of fetuses was different from adult procedure.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Li Y,Fang J,Hua Y,Wang C,Mu D,Zhou Kdoi
10.1155/2014/360687subject
Has Abstractpub_date
2014-01-01 00:00:00pages
360687eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Nematodes infections are responsible for debilitating conditions and economic losses in domestic animals as well as livestock and are considered an important public health problem due to the high prevalence in humans. The nematode resistance for drugs has been reported for livestock, highlighting the importance for de...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/879263
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to evaluate the safety and effectiveness of percutaneous transluminal angioplasty and stenting (PTAS) for intracranial atherosclerotic disease (ICAD) by conducting a meta-analysis. Two independent observers searched PubMed, EMBASE, and Cochrane Library for relevant studies up to 31 December 2...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2017/3258681
更新日期:2017-01-01 00:00:00
abstract::Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg bod...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8428304
更新日期:2019-12-03 00:00:00
abstract::Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function. This imbalance coincided with retinal ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/571456
更新日期:2015-01-01 00:00:00
abstract::Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temephos (OP), deltamethr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8603263
更新日期:2016-01-01 00:00:00
abstract::The microbial resistance of fungi and bacteria is currently considered a major public health problem. Esters derived from cinnamic acid have a broad spectrum of pharmacological properties that include antimicrobial activity. In this study, a collection of structurally related 4-chlorocinnamic acid esters was prepared ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3941242
更新日期:2019-04-23 00:00:00
abstract::Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8579619
更新日期:2019-01-20 00:00:00
abstract::Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is a complex multifactorial process. Animal models are essential to furthering understanding of the degenerative process and testing pot...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/5952165
更新日期:2016-01-01 00:00:00
abstract::Despite the rapid progression of cancer pharmacotherapy, the high drug resistance of pancreatic ductal adenocarcinoma (PDA) makes it one of the most lethal malignancies. Therefore, there are high expectations associated with experimental therapies, such as electrochemotherapy (ECT). This technique involves the applica...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7364539
更新日期:2018-03-19 00:00:00
abstract::Introduction. NOTCH pathway and TP53 protein are involved in the development of fibrosis and autoimmune disorders, respectively. The aim of this study was to evaluate the role of single nucleotide polymorphisms (SNPs) of NOTCH3 and TP53 genes and serum anti-TP53 antibodies with the susceptibility, clinical subset of s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8465971
更新日期:2020-02-25 00:00:00
abstract::Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to la...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1064029
更新日期:2016-01-01 00:00:00
abstract::We performed a retrospective review of 40 consecutive modern cementless THAs with 65-month mean followup in 34 patients under the age of 30 primarily for diagnoses other than inflammatory arthritis. We found acceptable functional improvement and radiographic outcomes at mean 5-year followup. We found a high transfusio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/649506
更新日期:2013-01-01 00:00:00
abstract::There is an emerging body of evidence that chemoresistance and minimal residual disease result from selective resistance of a cell subpopulation from the original tumor that is molecularly and phenotypically distinct. These cells are called "cancer stem cells" (CSCs). In this review, we analyze the potential targeting...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/859871
更新日期:2014-01-01 00:00:00
abstract:Introduction:The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6038106
更新日期:2018-01-02 00:00:00
abstract::Cardiovascular diseases (CVDs) are considered to be the predominant cause of death in the world. Chinese herb medicines (CHMs) have been widely used for the treatment of CVDs in Asian countries for thousands of years. One reason of high efficacy of CHMs in treating CVDs is attributed to their inhibition in atheroscler...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/5392375
更新日期:2018-06-13 00:00:00
abstract::Primary ciliary dyskinesia (PCD) is a clinical rare peculiar disorder, mainly featured by respiratory infection, tympanitis, nasosinusitis, and male infertility. Previous study demonstrated it is an autosomal recessive disease and by 2017 almost 40 pathologic genes have been identified. Among them are the leucine-rich...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1854269
更新日期:2018-01-08 00:00:00
abstract::Magnetic resonance imaging (MRI) based on the ferritin heavy chain 1 (FTH1) reporter gene has been used to trace stem cells. However, whether FTH1 expression is affected by stem cell differentiation or whether cell differentiation is affected by reporter gene expression remains unclear. Here, we explore the relationsh...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1978602
更新日期:2018-06-26 00:00:00
abstract::Since 2009 pandemic, international health authorities recommended monitoring severe and complicated cases of respiratory disease, that is, severe acute respiratory infection (SARI) and acute respiratory distress syndrome (ARDS). We evaluated the proportion of SARI/ARDS cases and deaths due to influenza A(H1N1)pdm09 in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/241298
更新日期:2014-01-01 00:00:00
abstract::Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anat...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/684127
更新日期:2014-01-01 00:00:00
abstract::We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions. Male Wistar rats were divided into four groups: control (CON), diabetic (DM; streptozotocin (STZ), i.v. 55 mg/kg BW), control-treated with cu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/161346
更新日期:2014-01-01 00:00:00
abstract::Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/480573
更新日期:2014-01-01 00:00:00
abstract::Acetabular fractures involving predominantly the anterior column associated with a disruption of the quadrilateral surface can be treated with instrumentation implementing the stabilization of the quadrilateral surface. The recently introduced suprapectineal quadrilateral buttress plate is specifically designed to pre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8231301
更新日期:2017-01-01 00:00:00
abstract::We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practic...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5387258
更新日期:2016-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2019/5879089.]. ...
journal_title:BioMed research international
pub_type: 撤回出版物
doi:10.1155/2020/5014928
更新日期:2020-08-26 00:00:00
abstract::This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2019/8345309
更新日期:2019-03-18 00:00:00
abstract::Non-small-cell lung cancer (NSCLC) patients often develop bone metastases (BM), and the overall survival for these patients is usually perishing. However, a model with high accuracy for predicting the survival of NSCLC with BM is still lacking. Here, we aimed to establish a model based on artificial intelligence for p...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3462363
更新日期:2020-06-27 00:00:00
abstract::The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6492183
更新日期:2016-01-01 00:00:00
abstract::New genomes are being sequenced at an increasingly rapid rate, far outpacing the rate at which manual gene annotation can be performed. Automated genome annotation is thus necessitated by this growth in genome projects; however, full-fledged annotation systems are usually home-grown and customized to a particular geno...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/502827
更新日期:2013-01-01 00:00:00
abstract:Background and Aims:Concordance between transient elastography (TE) and ultrasonography (US) in assessing liver fibrosis in patients with chronic hepatitis B (CHB) and concurrent nonalcoholic fatty liver disease (NAFLD) has been rarely studied. This study aimed to evaluate the individual and combined performances of TE...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3951574
更新日期:2019-01-23 00:00:00
abstract::Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder with core impairments in the social relationships, communication, imagination, or flexibility of thought and restricted repertoire of activity and interest. In this work, a new computer aided diagnosis (CAD) of autism based on electroencephalogra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9816591
更新日期:2017-01-01 00:00:00