Abstract:
:X-ray radiation resistance associated 1 (XRRA1) has been found to regulate the response of human tumor and normal cells to X-radiation (XR). Although XRRA1 overexpression is known to be involved in cancer cell response to XR, there are no reports about whether the expression of XRRA1 in tumors can adjust radioresistance. It is widely known that cell cycle arrest could cause radioresistance. We found that blocked XRRA1 expression could lead to cell cycle G2/M arrest by the regulation of cyclin A, cyclin E, and p21 proteins in colorectal cancer (CRC) and expression of XRRA1 reduced cell cycle arrest and increased cell proliferation in CRC. However, whether regulation of the cell cycle by XRRA1 can influence radioresistance is poorly characterized. Correspondingly, DNA repair can effectively lead to radioresistance. In our study, when cancer cells were exposed to drugs and ionizing radiation, low expression of XRRA1 could increase the phosphorylation of DNA repair pathway factors CHK1, CHK2, and ATM and reduce the expression of γ-H2AX, which is believed to participate in DNA repair in the nucleus. Crucially, our results identify a novel link between XRRA1 and the ATM/CHK1/2 pathway and suggest that XRRA1 is involved in a DNA damage response that drives radio- and chemoresistance by regulating the ATM/CHK1/2 pathway.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wang W,Guo M,Xia X,Zhang C,Zeng Y,Wu Sdoi
10.1155/2017/5718968subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5718968eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Vitamin D is important for normal development and maintenance of the skeleton. Hypovitaminosis D adversely affects calcium metabolism, osteoblastic activity, matrix ossification, bone remodeling and bone density. It is well known that Vit. D deficiency in the developing skeleton is related to rickets, while in adults ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/396541
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2017/6069374
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abstract::N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...
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doi:10.1155/2020/8826456
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3757149
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journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2014/313867
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pub_type: 杂志文章,评审
doi:10.1155/2017/4816527
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pub_type: 杂志文章,meta分析
doi:10.1155/2019/9853701
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pub_type: 杂志文章
doi:10.1155/2014/560183
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pub_type: 杂志文章
doi:10.1155/2015/612352
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更新日期:2019-04-03 00:00:00
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pub_type: 杂志文章
doi:10.1155/2019/7168949
更新日期:2019-03-17 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/636319
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pub_type: 杂志文章
doi:10.1155/2015/183523
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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doi:10.1155/2013/480702
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00