Abstract:
Methods:circRNA expression was analysed in six cerebrospinal fluid (CSF) samples from three patients of the infectious and noninfectious phases using an Arraystar Human circRNA Array. Differentially altered circRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR) in the 66 CSF samples of 33 patients of the infectious and noninfectious phases. t-test was used for statistical analysis. A bioinformatics analysis was employed to investigate the function mechanism of the circRNAs. Results:Firstly, 142 circRNAs were found significantly different in 6 CSF samples of the infection and noninfection phases of 3 patients. Fourteen circRNAs with the top largest fold changes were chosen from the 142 circRNAs for PCR validation in the same 6 CSF samples of 3 patients. Three circRNAs were selected to be validated in 60 CSF samples of 30 patients using the PCR test. In infection CSF, an upregulated hsa_circRNA_402632 and downregulated hsa_circRNA_008636 and hsa_circRNA_405481 were confirmed by PCR test. A bioinformatics analysis was used to investigate the function mechanism of the 3 circRNAs. hsa_circRNA_402632 is enriched in the insulin resistance pathway, the FoxO and AMPK signaling pathways are the most important pathways for hsa_circRNA_008636 gene expression, and hsa_circRNA_405481 is enriched in the endometrial cancer signaling pathway, Fc epsilon RI signaling pathway, and TGF-beta signaling pathway. Conclusions:hsa_circRNA_402632, hsa_circRNA_008636, and hsa_circRNA_405481 may be potential diagnostic markers for central nervous system infection after neurological surgery.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Niu J,Xu H,Yang Bdoi
10.1155/2020/2536272subject
Has Abstractpub_date
2020-05-02 00:00:00pages
2536272eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::The intra- and extracellular accumulation of misfolded and aggregated amyloid proteins is a common feature in several neurodegenerative diseases, which is thought to play a major role in disease severity and progression. The principal machineries maintaining proteostasis are the ubiquitin proteasomal and lysosomal aut...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/495091
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569130
更新日期:2014-01-01 00:00:00
abstract::MicroRNAs (miRs) are small noncoding RNA molecules and recently have demonstrated that altered expression and functions are their tight association with ulcerative colitis (UC). Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 i...
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pub_type: 杂志文章
doi:10.1155/2017/8524972
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/725410
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4192745
更新日期:2020-02-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-07-22 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2016/4864195
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journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
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更新日期:2020-07-18 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 已发布勘误
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2020-05-21 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4250329
更新日期:2020-07-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812157
更新日期:2020-11-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/406389
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2014/460106
更新日期:2014-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/569470
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8562329
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8718097
更新日期:2020-08-10 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2014/210560
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7501807
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841798
更新日期:2014-01-01 00:00:00