Rectal Cancer: Redox State of Venous Blood and Tissues of Blood Vessels from Electron Paramagnetic Resonance and Its Correlation with the Five-Year Survival.

Abstract:

:A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial. The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventional and spin-trapping electron paramagnetic resonance (EPR). The intensity of the signals from ceruloplasmin (CP), transferrin (TF), and labile iron pool (LIP) at temperature T = 77 K as well as superoxide generation rate and nitric oxide (NO) levels at T = 300 K is measured. The reduced CP and TF activity and decreased NO levels increased LIP levels and superoxide-generating rates are detected in blood species. Correlation analysis for the five-year survival rate as a function of the extracted values is done. The results show that the intensities of the corresponding EPR signals from the "native" and "trapped" paramagnetic centers can be potentially used for the understanding of the molecular mechanisms underlying the RC progression and treatment.

journal_name

Biomed Res Int

authors

Burlaka AP,Vovk AV,Burlaka AA,Gafurov MR,Iskhakova KB,Lukin SN

doi

10.1155/2018/4848652

subject

Has Abstract

pub_date

2018-08-13 00:00:00

pages

4848652

eissn

2314-6133

issn

2314-6141

journal_volume

2018

pub_type

杂志文章
  • Health Effects of 12 Weeks of Team-Sport Training and Fitness Training in a Community Health Centre for Sedentary Men with Lifestyle Diseases.

    abstract::This study compares the effects of team-sport training, for sedentary men with lifestyle diseases, with fitness training in a pragmatic set-up in a community health centre (CHC). Thirty-two men in the fitness group (FiG) and 36 men in the team-sport group (TsG) completed the training and trained for 60-90 min, two tim...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/1571807

    authors: Møller TK,Nielsen TT,Andersen R,Lundager I,Hansen HF,Ottesen L,Krustrup P,Randers MB

    更新日期:2018-05-15 00:00:00

  • Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats.

    abstract::We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraper...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/526367

    authors: Zhang Y,Ye C,Wang G,Gao Y,Tan K,Zhuo Z,Liu Z,Xia H,Yang D,Li P

    更新日期:2013-01-01 00:00:00

  • Identification of Gene Biomarkers for Distinguishing Small-Cell Lung Cancer from Non-Small-Cell Lung Cancer Using a Network-Based Approach.

    abstract::Lung cancer consists of two main subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) that are classified according to their physiological phenotypes. In this study, we have developed a network-based approach to identify molecular biomarkers that can distinguish SCLC from NSCLC. By identifyin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/685303

    authors: Long F,Su JH,Liang B,Su LL,Jiang SJ

    更新日期:2015-01-01 00:00:00

  • Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence.

    abstract::Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/143109

    authors: Weylandt KH,Serini S,Chen YQ,Su HM,Lim K,Cittadini A,Calviello G

    更新日期:2015-01-01 00:00:00

  • TLR stimulation of bone marrow lymphoid precursors from childhood acute leukemia modifies their differentiation potentials.

    abstract::Acute leukemias are the most frequent childhood malignancies worldwide and remain a leading cause of morbidity and mortality of relapsed patients. While remarkable progress has been made in characterizing genetic aberrations that may control these hematological disorders, it has also become clear that abnormalities in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/846724

    authors: Dorantes-Acosta E,Vadillo E,Contreras-Quiroz A,Balandrán JC,Arriaga-Pizano L,Purizaca J,Huerta-Yepez S,Jiménez E,Aguilera W,Medina-Sanson A,Mayani H,Pelayo R

    更新日期:2013-01-01 00:00:00

  • Emergency versus Elective Cervical Cerclage: An Audit of Our First Two Years of Service.

    abstract::One of the biggest obstetric challenges is the diagnosis and management of a short cervix as cervical length has an inverse relationship with risk of preterm birth. A cervical cerclage is a surgical procedure to reduce the risk of preterm birth and can be placed in an elective or emergency setting. This is a retrospec...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2018/2065232

    authors: Vasudeva N,Reddington C,Bogdanska M,De Luca L

    更新日期:2018-09-30 00:00:00

  • Riluzole stimulates BDNF release from human platelets.

    abstract::Brain-derived neurotrophic factor (BDNF) has several functions in the central nervous system, where it contributes to brain development and its functionality through affecting neuronal survival and activity and also modulating neurotransmitter levels. This neurotrophin is also found in the serum, but its origin and pe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/189307

    authors: Türck P,Frizzo ME

    更新日期:2015-01-01 00:00:00

  • Modification of Mechanical Properties, Polymerization Temperature, and Handling Time of Polymethylmethacrylate Cement for Enhancing Applicability in Vertebroplasty.

    abstract::Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material's excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentione...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7901562

    authors: Tai CL,Lai PL,Lin WD,Tsai TT,Lee YC,Liu MY,Chen LH

    更新日期:2016-01-01 00:00:00

  • IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients.

    abstract::Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall surviva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/654727

    authors: Stancheva G,Goranova T,Laleva M,Kamenova M,Mitkova A,Velinov N,Poptodorov G,Mitev V,Kaneva R,Gabrovsky N

    更新日期:2014-01-01 00:00:00

  • Nonconventional Use of Flash-Lamp Pulsed-Dye Laser in Dermatology.

    abstract::Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement....

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2016/7981640

    authors: Nisticò S,Campolmi P,Moretti S,Del Duca E,Bruscino N,Conti R,Bassi A,Cannarozzo G

    更新日期:2016-01-01 00:00:00

  • New bioactive fungal molecules with high antioxidant and antimicrobial capacity isolated from Cerrena unicolor idiophasic cultures.

    abstract::Three bioactive fractions, extracellular laccase (ex-LAC), crude endopolysaccharides (c-EPL), and a low molecular subfraction of secondary metabolites (ex-LMS), were isolated from the idiophasic cultures of the white rot fungus Cerrena unicolor. For the first time, we determined the antioxidant properties of these sam...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/497492

    authors: Jaszek M,Osińska-Jaroszuk M,Janusz G,Matuszewska A,Stefaniuk D,Sulej J,Polak J,Ruminowicz M,Grzywnowicz K,Jarosz-Wilkołazka A

    更新日期:2013-01-01 00:00:00

  • A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma.

    abstract::Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/480573

    authors: Léonard B,Kridelka F,Delbecque K,Goffin F,Demoulin S,Doyen J,Delvenne P

    更新日期:2014-01-01 00:00:00

  • Statistical optimization of fibrinolytic enzyme production using agroresidues by Bacillus cereus IND1 and its thrombolytic activity in vitro.

    abstract::A potent fibrinolytic enzyme-producing Bacillus cereus IND1 was isolated from the Indian food, rice. Solid-state fermentation was carried out using agroresidues for the production of fibrinolytic enzyme. Among the substrates, wheat bran supported more enzyme production and has been used for the optimized enzyme produc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/725064

    authors: Vijayaraghavan P,Vincent SG

    更新日期:2014-01-01 00:00:00

  • Evaluation and Identification of the Neuroprotective Compounds of Xiaoxuming Decoction by Machine Learning: A Novel Mode to Explore the Combination Rules in Traditional Chinese Medicine Prescription.

    abstract::Xiaoxuming decoction (XXMD), a classic traditional Chinese medicine (TCM) prescription, has been used as a therapeutic in the treatment of stroke in clinical practice for over 1200 years. However, the pharmacological mechanisms of XXMD have not yet been elucidated. The purpose of this study was to develop neuroprotect...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6847685

    authors: Yang S,Shen Y,Lu W,Yang Y,Wang H,Li L,Wu C,Du G

    更新日期:2019-07-10 00:00:00

  • Corrigendum to "Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly".

    abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2020/9175369

    authors: Arosio B,D'Addario C,Gussago C,Casati M,Tedone E,Ferri E,Nicolini P,Rossi PD,Maccarrone M,Mari D

    更新日期:2020-09-07 00:00:00

  • A Novel Computer-Aided Diagnosis Scheme on Small Annotated Set: G2C-CAD.

    abstract:Purpose:Computer-aided diagnosis (CAD) can aid in improving diagnostic level; however, the main problem currently faced by CAD is that it cannot obtain sufficient labeled samples. To solve this problem, in this study, we adopt a generative adversarial network (GAN) approach and design a semisupervised learning algorith...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6425963

    authors: Zheng G,Han G,Soomro NQ,Ma L,Zhang F,Zhao Y,Zhao X,Zhou C

    更新日期:2019-04-15 00:00:00

  • Anion Gap Was Associated with Inhospital Mortality and Adverse Clinical Outcomes of Coronary Care Unit Patients.

    abstract:Background:Anion gap (AG) has been proved to be associated with prognosis of many cardiovascular diseases. This study is aimed at exploring the association of AG with inhospital all-cause mortality and adverse clinical outcomes in coronary care unit (CCU) patients. Method:All data of this study was extracted from Medi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4598462

    authors: Sun T,Cai C,Shen H,Yang J,Guo Q,Zhang J,Zhang B,Ding Y,Zhou Y

    更新日期:2020-08-27 00:00:00

  • NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis.

    abstract::Introduction. NOTCH pathway and TP53 protein are involved in the development of fibrosis and autoimmune disorders, respectively. The aim of this study was to evaluate the role of single nucleotide polymorphisms (SNPs) of NOTCH3 and TP53 genes and serum anti-TP53 antibodies with the susceptibility, clinical subset of s...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8465971

    authors: Zmorzyński S,Wojcierowska-Litwin M,Kowal M,Michalska-Jakubus M,Styk W,Filip AA,Walecka I,Krasowska D

    更新日期:2020-02-25 00:00:00

  • Mycobacterium-Host Cell Relationships in Granulomatous Lesions in a Mouse Model of Latent Tuberculous Infection.

    abstract::Tuberculosis (TB) is a dangerous infectious disease characterized by a tight interplay between mycobacteria and host cells in granulomatous lesions (granulomas) during the latent, asymptomatic stage of infection. Mycobacterium-host cell relationships were analyzed in granulomas obtained from various organs of BALB/c m...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/948131

    authors: Ufimtseva E

    更新日期:2015-01-01 00:00:00

  • Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer.

    abstract::Canine inflammatory mammary cancer (IMC) shares clinical and histopathological characteristics with human inflammatory breast cancer (IBC) and has been proposed as a good model for studying the human disease. The aim of this study was to evaluate the capacity of female and male mice to reproduce IMC and IBC tumors and...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8909878

    authors: Caceres S,Peña L,Silvan G,Illera MJ,Woodward WA,Reuben JM,Illera JC

    更新日期:2016-01-01 00:00:00

  • Alpha-linolenic acid: an omega-3 fatty acid with neuroprotective properties-ready for use in the stroke clinic?

    abstract::Alpha-linolenic acid (ALA) is plant-based essential omega-3 polyunsaturated fatty acids that must be obtained through the diet. This could explain in part why the severe deficiency in omega-3 intake pointed by numerous epidemiologic studies may increase the brain's vulnerability representing an important risk factor i...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/519830

    authors: Blondeau N,Lipsky RH,Bourourou M,Duncan MW,Gorelick PB,Marini AM

    更新日期:2015-01-01 00:00:00

  • Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis.

    abstract::Exposure to dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is reported to affect the autoimmune system and increase the risk of autoimmune disease. Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR). Primary biliary cholangitis (PBC) is a chronic autoimmune disease, and its pathoge...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1754975

    authors: She C,Wang J,Tang N,Liu Z,Xu L,Liu B

    更新日期:2020-08-24 00:00:00

  • Effect of Gamma Rays on Sophora davidii and Detection of DNA Polymorphism through ISSR Marker.

    abstract::Sophora davidii (Franch.) Kom. ex Pavol is an important medicinal plant and a feeding scrub with ecological value. The effects of different gamma irradiation doses (20-140 Kr) on seed germination and seedling morphology were investigated in S. davidii, and intersimple sequence repeat (ISSR) markers were used to identi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8576404

    authors: Wang P,Zhang Y,Zhao L,Mo B,Luo T

    更新日期:2017-01-01 00:00:00

  • A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis.

    abstract::Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature. In this review, the author offers a 3-step pathway of pathogenesis for syndactyly. The first step is initiated either by the overactivation of the WNT canonical pathway or the...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9652649

    authors: Al-Qattan MM

    更新日期:2019-09-15 00:00:00

  • Corrigendum to "Tabu Search and Machine-Learning Classification of Benign and Malignant Proliferative Breast Lesions".

    abstract::[This corrects the article DOI: 10.1155/2020/4671349.]. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,已发布勘误

    doi:10.1155/2020/7638969

    authors: Dhahri H,Rahmany I,Mahmood A,Al Maghayreh E,Elkilani W

    更新日期:2020-06-30 00:00:00

  • Curcuma longa Is Able to Induce Apoptotic Cell Death of Pterygium-Derived Human Keratinocytes.

    abstract::Pterygium is a relatively common eye disease that can display an aggressive clinical behaviour. To evaluate the in vitro effects of Curcuma longa on human pterygium-derived keratinocytes, specimens of pterygium from 20 patients undergoing pterygium surgical excision were collected. Pterygium explants were put into cul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2956597

    authors: Sancilio S,Di Staso S,Sebastiani S,Centurione L,Di Girolamo N,Ciancaglini M,Di Pietro R

    更新日期:2017-01-01 00:00:00

  • Association between Sedentary Behaviour and Physical, Cognitive, and Psychosocial Status among Older Adults in Assisted Living.

    abstract:OBJECTIVE:Identification of the factors that influence sedentary behaviour in older adults is important for the design of appropriate intervention strategies. In this study, we determined the prevalence of sedentary behaviour and its association with physical, cognitive, and psychosocial status among older adults resid...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/9160504

    authors: Leung PM,Ejupi A,van Schooten KS,Aziz O,Feldman F,Mackey DC,Ashe MC,Robinovitch SN

    更新日期:2017-01-01 00:00:00

  • Comparison of the Superior and Inferior Rectus Muscles in Humans: An Anatomical Study with Notes on Morphology, Anatomical Variations, and Intramuscular Innervation Patterns.

    abstract::A comparison of the superior and inferior rectus muscles was performed to determine whether they have similar structures and innervation attributable to their participation in the same type of, although antagonistic, eye movements. The study was conducted on 70 cadaveric hemiheads, and the anatomical variations in the...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9037693

    authors: Haładaj R,Polguj M,Tubbs RS

    更新日期:2020-04-30 00:00:00

  • Oligomannose-coated liposome as a novel adjuvant for the induction of cellular immune responses to control disease status.

    abstract::Professional phagocytic cells, such as dendritic cells, are mainly responsible for phagocytosis, antigen presentation, and cytokine secretion, which induce subsequent activation of T cell-mediated immunity. Thus, strategies that deliver antigens and stimulatory signals to the cells have significant implications for va...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/562924

    authors: Kojima N,Ishii M,Kawauchi Y,Takagi H

    更新日期:2013-01-01 00:00:00

  • Variation Overtime among Patients of the Six Methadone Maintenance Treatment Clinics in Thai Nguyen from 2011 to 2015.

    abstract:Background:Methadone Maintenance Treatment (MMT) program's success depends on the likelihood of reducing drop-out rate and keeping patients remaining in the program. There have been neither comprehensive studies about variation among patients who have been experiencing MMT for long period nor prediction of MMT period i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9081968

    authors: Dao ATM,Nguyen HTT,Nguyen LH

    更新日期:2018-08-07 00:00:00