Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer.

Abstract:

:Canine inflammatory mammary cancer (IMC) shares clinical and histopathological characteristics with human inflammatory breast cancer (IBC) and has been proposed as a good model for studying the human disease. The aim of this study was to evaluate the capacity of female and male mice to reproduce IMC and IBC tumors and identify the hormonal tumor environment. To perform the study sixty 6-8-week-old male and female mice were inoculated subcutaneously with a suspension of 10(6)IPC-366 and SUM149 cells. Tumors and serum were collected and used for hormonal analysis. Results revealed that IPC-366 reproduced tumors in 90% of males inoculated after 2 weeks compared with 100% of females that reproduced tumor at the same time. SUM149 reproduced tumors in 40% of males instead of 80% of females that reproduced tumors after 4 weeks. Both cell lines produce distant metastasis in lungs being higher than the metastatic rates in females. EIA analysis revealed that male tumors had higher T and SO4E1 concentrations compared to female tumors. Serum steroid levels were lower than those found in tumors. In conclusion, IBC and IMC male mouse model is useful as a tool for IBC research and those circulating estrogens and intratumoral hormonal levels are crucial in the development and progression of tumors.

journal_name

Biomed Res Int

authors

Caceres S,Peña L,Silvan G,Illera MJ,Woodward WA,Reuben JM,Illera JC

doi

10.1155/2016/8909878

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

8909878

eissn

2314-6133

issn

2314-6141

journal_volume

2016

pub_type

杂志文章
  • Preparation of three-dimensional vascularized MSC cell sheet constructs for tissue regeneration.

    abstract::Engineering three-dimensional (3D) vascularized constructs remains a challenge due to the inability to form rich microvessel networks. In this study we engineered a prevascularized 3D cell sheet construct for tissue regeneration using human bone marrow-derived mesenchymal stem cells (hMSCs) and human umbilical vein en...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/301279

    authors: Ren L,Ma D,Liu B,Li J,Chen J,Yang D,Gao P

    更新日期:2014-01-01 00:00:00

  • MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far.

    abstract::Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by variable expressivity, age penetrance, and a high heterogeneity. The transcriptional profile (miRNAs, mRNAs), epigenetic modifications, and posttranslational modifications seem to be highly relevant for the onset of the disease. miRNAs...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/983290

    authors: Roma-Rodrigues C,Raposo LR,Fernandes AR

    更新日期:2015-01-01 00:00:00

  • Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy.

    abstract:Design:From July 2016 to June 2018, 36 women with symptomatic early pregnancy around 4-8 weeks of gestation were recruited into the study. Among them, there were 16 women with viable intrauterine pregnancy (VIP), 9 women with spontaneous abortion (SA), and 11 women of EP. Serum exosomal miRNAs were extracted and measur...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3521859

    authors: Sun J,Deng G,Ruan X,Chen S,Liao H,Liu X,Li J,Zhao G,Gao J

    更新日期:2020-06-11 00:00:00

  • Biochemical and Molecular Phylogenetic Study of Agriculturally Useful Association of a Nitrogen-Fixing Cyanobacterium and Nodule Sinorhizobium with Medicago sativa L.

    abstract::Seed inoculation with bacterial consortium was found to increase legume yield, providing a higher growth than the standard nitrogen treatment methods. Alfalfa plants were inoculated by mono- and binary compositions of nitrogen-fixing microorganisms. Their physiological and biochemical properties were estimated. Inocul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/202597

    authors: Karaushu EV,Lazebnaya IV,Kravzova TR,Vorobey NA,Lazebny OE,Kiriziy DA,Olkhovich OP,Taran NY,Kots SY,Popova AA,Omarova E,Koksharova OA

    更新日期:2015-01-01 00:00:00

  • Atypical enteropathogenic Escherichia coli strains form biofilm on abiotic surfaces regardless of their adherence pattern on cultured epithelial cells.

    abstract::The aim of this study was to determine the capacity of biofilm formation of atypical enteropathogenic Escherichia coli (aEPEC) strains on abiotic and biotic surfaces. Ninety-one aEPEC strains, isolated from feces of children with diarrhea, were analyzed by the crystal violet (CV) assay on an abiotic surface after 24 h...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/845147

    authors: Culler HF,Mota CM,Abe CM,Elias WP,Sircili MP,Franzolin MR

    更新日期:2014-01-01 00:00:00

  • Removal of Cu, Zn, Pb, and Cr from Yangtze Estuary Using the Phragmites australis Artificial Floating Wetlands.

    abstract::Contamination of heavy metals would threaten the water and soil resources; phytoremediation can be potentially used to remediate metal contaminated sites. We constructed the Phragmites australis artificial floating wetlands outside the Qingcaosha Reservoir in the Yangtze Estuary. Water characteristic variables were me...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6201048

    authors: Huang X,Zhao F,Yu G,Song C,Geng Z,Zhuang P

    更新日期:2017-01-01 00:00:00

  • Spider silk as guiding biomaterial for human model neurons.

    abstract::Over the last years, a number of therapeutic strategies have emerged to promote axonal regeneration. An attractive strategy is the implantation of biodegradable and nonimmunogenic artificial scaffolds into injured peripheral nerves. In previous studies, transplantation of decellularized veins filled with spider silk f...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/906819

    authors: Roloff F,Strauß S,Vogt PM,Bicker G,Radtke C

    更新日期:2014-01-01 00:00:00

  • Adipose tissue-derived stem cell secreted IGF-1 protects myoblasts from the negative effect of myostatin.

    abstract::Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Mu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/129048

    authors: Gehmert S,Wenzel C,Loibl M,Brockhoff G,Huber M,Krutsch W,Nerlich M,Gosau M,Klein S,Schreml S,Prantl L,Gehmert S

    更新日期:2014-01-01 00:00:00

  • A Novel Phosphorylation Site-Kinase Network-Based Method for the Accurate Prediction of Kinase-Substrate Relationships.

    abstract::Protein phosphorylation is catalyzed by kinases which regulate many aspects that control death, movement, and cell growth. Identification of the phosphorylation site-specific kinase-substrate relationships (ssKSRs) is important for understanding cellular dynamics and provides a fundamental basis for further disease-re...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/1826496

    authors: Wang M,Wang T,Wang B,Liu Y,Li A

    更新日期:2017-01-01 00:00:00

  • Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population.

    abstract::The aim of this study was to investigate whether osteopontin (OPN) variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. Polymorphisms at the 9175th position in exon 7 of OPN and rs17524488 were genotyped using direct sequencing in 186 unrelated AS patients and 188 ethnica...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3458439

    authors: Li J,Cai Y,Wang Z,Deng A,Yang G

    更新日期:2018-01-18 00:00:00

  • Role and Importance of IGF-1 in Traumatic Brain Injuries.

    abstract::It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a tar...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/736104

    authors: Mangiola A,Vigo V,Anile C,De Bonis P,Marziali G,Lofrese G

    更新日期:2015-01-01 00:00:00

  • Comparisons of Jaw Line and Face Line after Mandibular Setback: Intraoral Vertical Ramus versus Sagittal Split Ramus Osteotomies.

    abstract:Background:This study investigates the differences in the lateral profile and frontal appearance after sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO) procedures for the correction of mandibular prognathism. Methods:Sixty patients (30 SSRO and 30 IVRO) underwent mandibular setback s...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1375085

    authors: Chen CM,Tseng YC,Ko EC,Chen MY,Chen KJ,Cheng JH

    更新日期:2018-12-18 00:00:00

  • Effect of modulated alternating and direct current iontophoresis on transdermal delivery of lidocaine hydrochloride.

    abstract::The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/537941

    authors: Bhatia G,Banga AK

    更新日期:2014-01-01 00:00:00

  • Computational selection of RNA aptamer against angiopoietin-2 and experimental evaluation.

    abstract::Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/658712

    authors: Hu WP,Kumar JV,Huang CJ,Chen WY

    更新日期:2015-01-01 00:00:00

  • Coconut Water: An Unexpected Source of Urinary Citrate.

    abstract:Purpose:Coconut water has long been touted for its medicinal qualities including natural hydration. We sought to determine whether its consumption would induce changes to urinary lithogenic factors beyond changes in urine volume. Materials and Methods:After Institutional Review Board approval, volunteers with no prior...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3061742

    authors: Patel RM,Jiang P,Asplin J,Granja I,Capretz T,Osann K,Okhunov Z,Landman J,Clayman RV

    更新日期:2018-11-01 00:00:00

  • Multiblock discriminant analysis for integrative genomic study.

    abstract::Human diseases are abnormal medical conditions in which multiple biological components are complicatedly involved. Nevertheless, most contributions of research have been made with a single type of genetic data such as Single Nucleotide Polymorphism (SNP) or Copy Number Variation (CNV). Furthermore, epigenetic modifica...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/783592

    authors: Kang M,Kim DC,Liu C,Gao J

    更新日期:2015-01-01 00:00:00

  • Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study.

    abstract::N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8826456

    authors: Zhang Q,Cai Y,Kurbatov V,Khan SA,Lu L,Zhang Y,Johnson CH

    更新日期:2020-12-19 00:00:00

  • Unilateral Multifocality and Bilaterality Could Be Two Different Multifocal Entities in Patients with Papillary Thyroid Microcarcinoma.

    abstract:Objective:Multifocality within an affected lobe (unilateral multifocality) or two lobes (bilaterality) is commonly denoted as multifocality without differentiation. Recently, there has been molecular evidence indicating that unilateral multifocality and bilaterality could be two different entities. However, few studies...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9854964

    authors: Cai J,Fang F,Chen J,Xiang D

    更新日期:2020-07-03 00:00:00

  • Analysis of the time and location of the silicone oil emulsification by spectral-domain optical coherence tomography after silicone oil tamponade.

    abstract:PURPOSE:To estimate localization and the period up to the appearance of small hyperreflective round-shaped droplets using spectral-domain optical coherence tomography (SD-OCT) after pars plana vitrectomy with silicone oil tamponade. METHODS:A retrospective observational study included 24 patients who had undergone par...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/372045

    authors: Odrobina D,Laudańska-Olszewska I

    更新日期:2014-01-01 00:00:00

  • Effects of Vitamin D Restricted Diet Administered during Perinatal and Postnatal Periods on the Penis of Wistar Rats.

    abstract::Vitamin D deficiency is common in pregnant women and infants. The present study aimed to investigate the effects of vitamin D restricted diet on the Wistar rats offspring penis morphology. Mother rats received either standard diet (SC) or vitamin D restricted (VitD) diet. At birth, offspring were divided into SC/SC (f...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6030646

    authors: Fernandes-Lima F,Gregório BM,Nascimento FAM,Costa WS,Gallo CBM,Sampaio FJB

    更新日期:2018-04-23 00:00:00

  • Evaluation of pediatric manual wheelchair mobility using advanced biomechanical methods.

    abstract::There is minimal research of upper extremity joint dynamics during pediatric wheelchair mobility despite the large number of children using manual wheelchairs. Special concern arises with the pediatric population, particularly in regard to the longer duration of wheelchair use, joint integrity, participation and commu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/634768

    authors: Slavens BA,Schnorenberg AJ,Aurit CM,Graf A,Krzak JJ,Reiners K,Vogel LC,Harris GF

    更新日期:2015-01-01 00:00:00

  • Understanding the Correlation between Tomographic and Biomechanical Severity of Keratoconic Corneas.

    abstract::Purpose. To evaluate correlation between tomographic gradation of keratoconus (KC) and its corresponding air-puff induced biomechanical response. Methods. Corneal tomography and biomechanics were measured with Scheimpflug imaging in 44 normal and 92 KC corneas. Deformation waveform was also analyzed with Fourier serie...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/294197

    authors: Shetty R,Nuijts RM,Srivatsa P,Jayadev C,Pahuja N,Akkali MC,Sinha Roy A

    更新日期:2015-01-01 00:00:00

  • Neck Circumference as a Predictive Indicator of CKD for High Cardiovascular Risk Patients.

    abstract:BACKGROUND:Neck circumference (NC) is an anthropometric measure of obesity for upper subcutaneous adipose tissue distribution which is associated with cardiometabolic risk. This study investigated whether NC is associated with indicators of chronic kidney disease (CKD) for high cardiometabolic risk patients. METHODS:A...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/745410

    authors: Liu YF,Chang ST,Lin WS,Hsu JT,Chung CM,Chang JJ,Hung KC,Chen KH,Chang CW,Chen FC,Shih YW,Chu CM

    更新日期:2015-01-01 00:00:00

  • In vitro culture-induced pluripotency of human spermatogonial stem cells.

    abstract::Unipotent spermatogonial stem cells (SSCs) can be transformed into ESC-like cells that exhibit pluripotency in vitro. However, except for mouse models, their characterization and their origins have remained controversies in other models including humans. This controversy has arisen primarily from the lack of the direc...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/143028

    authors: Lim JJ,Kim HJ,Kim KS,Hong JY,Lee DR

    更新日期:2013-01-01 00:00:00

  • Artificial Liver and Renal Support System for Cynomolgus Monkeys with Surgery-Induced Acute Renal Failure: A Preclinical Study.

    abstract::Renal dysfunction is one of the most common complications of liver cirrhosis and is associated with increased morbidity and mortality. However, no available technology can simultaneously support liver and renal function in these patients. The aim of this study was to evaluate the safety and efficacy of an artificial l...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7456898

    authors: Feng L,He G,Cai L,Fu C,Li Y,Weng J,Huo X,Peng Q,Gao Y

    更新日期:2018-05-24 00:00:00

  • The use of infrared thermography as a rapid, quantitative, and noninvasive method for evaluation of inflammation response in different anatomical regions of rats.

    abstract:PURPOSE:Thermographic assessment of temperature distribution within the examined tissues allows a quick, noncontact, noninvasive measurement of their temperature. The aim of the study was to evaluate the usefulness of digital infrared imaging in monitoring experimental inflammation of pleura (PL), lower lip (LL), and l...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/972535

    authors: Całkosiński I,Dobrzyński M,Rosińczuk J,Dudek K,Chrószcz A,Fita K,Dymarek R

    更新日期:2015-01-01 00:00:00

  • Epidemiology, phylogeny, and evolution of emerging enteric Picobirnaviruses of animal origin and their relationship to human strains.

    abstract::Picobirnavirus (PBV) which has been included in the list of viruses causing enteric infection in animals is highly versatile because of its broad host range and genetic diversity. PBVs are among the most recent and emerging small, nonenveloped viruses with a bisegmented double-stranded RNA genome, classified under a n...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/780752

    authors: Malik YS,Kumar N,Sharma K,Dhama K,Shabbir MZ,Ganesh B,Kobayashi N,Banyai K

    更新日期:2014-01-01 00:00:00

  • The Early Clinical Outcomes of a Percutaneous Full-Endoscopic Interlaminar Approach via a Surrounding Nerve Root Discectomy Operative Route for the Treatment of Ventral-Type Lumbar Disc Herniation.

    abstract::The objective of this study is to introduce a method using a percutaneous full-endoscopic interlaminar approach via a surrounding nerve root discectomy (SNRD) operative route that involves removing the protrusive disc via both the shoulder and the axilla of the corresponding nerve root for the treatment of ventral-typ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/9157089

    authors: Shi C,Kong W,Liao W,Lu Y,Fu Y,Wen H,Du Q,Wu F

    更新日期:2018-02-12 00:00:00

  • Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis.

    abstract:Background:Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be relate...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/5190587

    authors: Liu J,Wang G,Peng Z

    更新日期:2020-05-20 00:00:00

  • In Vitro Comparison of Fluoride, Magnesium, and Calcium Phosphate Materials on Prevention of White Spot Lesions around Orthodontic Brackets.

    abstract::One common negative side effect of orthodontic treatment with fixed appliances is the development of white spot lesions (WSLs) around brackets. This study is aimed at comparing the efficacy of various oral hygiene practices in preventing enamel demineralization around orthodontic brackets under similar in vitro condit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1989817

    authors: Lale S,Solak H,Hınçal E,Vahdettin L

    更新日期:2020-03-30 00:00:00