Abstract:
:Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by variable expressivity, age penetrance, and a high heterogeneity. The transcriptional profile (miRNAs, mRNAs), epigenetic modifications, and posttranslational modifications seem to be highly relevant for the onset of the disease. miRNAs, small noncoding RNAs with 22 nucleotides, have been implicated in the regulation of cardiomyocyte function, being differentially expressed in several heart diseases, including HCM. Moreover, a different miRNA expression profile in the various stages of HCM development is also observed. This review summarizes the current knowledge of the profile of miRNAs characteristic of asymptomatic to overt HCM patients, discussing alongside their potential use for diagnosis and therapy. Indeed, the stability and specificity of miRNAs make them suitable targets for use as biomarkers for diagnosis and prognosis and as therapeutical targets.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Roma-Rodrigues C,Raposo LR,Fernandes ARdoi
10.1155/2015/983290subject
Has Abstractpub_date
2015-01-01 00:00:00pages
983290eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::Periodontitis is an inflammatory disease involving complex interactions between oral microorganisms and the host immune response. Understanding the structure of the microbiota community associated with periodontitis is essential for improving classifications and diagnoses of various types of periodontal diseases and w...
journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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doi:10.1155/2013/395806
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/618021
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4916497
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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journal_title:BioMed research international
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doi:10.1155/2019/8054640
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/380531
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2017/2108497
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/820813
更新日期:2015-01-01 00:00:00
abstract::Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/832049
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1250721
更新日期:2018-11-21 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/890630
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/432645
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8541402
更新日期:2019-06-16 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5125836
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4560647
更新日期:2018-05-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9436280
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/5187549
更新日期:2018-05-27 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/635732
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6109497
更新日期:2020-06-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9160504
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8432934
更新日期:2020-07-30 00:00:00
abstract::Newcastle disease (ND) is one of the most devastating diseases that considerably cripple the global poultry industry. Because of its enormous socioeconomic importance and potential to rapidly spread to naïve birds in the vicinity, ND is included among the list of avian diseases that must be notified to the OIE immedia...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/7278459
更新日期:2018-08-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9597276
更新日期:2016-01-01 00:00:00
abstract::Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that s...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/929531
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/964942
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6052125
更新日期:2016-01-01 00:00:00