Abstract:
Background:Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature. To better estimate the relationship between the MMP-1 gene polymorphism and OA, a comprehensive meta-analysis of relevant literature was carried out. Results:In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta-analysis. The combined results revealed no significant association between the MMP-1-1607 1G/2G polymorphism and risk of OA in the five genetic models. However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP-1-1607 1G/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs. 1G: OR = 1.575, 95%CI = 1.259-1.972, P < 0.01; recessive: 2G2G vs. 1G1G+1G2G: OR = 2.411, 95%CI = 1.658-3.504, P < 0.01; and homozygote: 2G2G vs. 1G1G: OR = 2.313, 95%CI = 1.341, 3.991, P = 0.003), the younger subgroup (aged less than 60 years; allelic: 2G vs. 1G: OR = 1.635, 95%CI = 1.354, 1.974, P < 0.01; dominant: 2G1G+2G2G vs. 1G1G: OR = 1.622, 95%CI = 1.158, 2.271, P = 0.005; recessive: 2G2G vs. 1G1G+1G2G: OR = 2.209, 95%CI = 1.718, 2.840, P < 0.01; and homozygote: 2G2G vs. 1G1G: OR = 2.578, 95%CI = 1.798, 3.696, P < 0.01), the larger subgroup (N > 300), and the hospital-based case-control study (HCC) subgroup. The sensitivity analysis suggested that the results of the meta-analysis were stable and reliable. Begg's funnel plot and Egger's test indicated that there was no publication bias in this study. Conclusion:Our meta-analysis indicated that although the MMP-1-1607 1G/2G polymorphism was not significantly associated with OA susceptibility among the whole sample, it played a key role in the etiology and development of TMJ OA and OA in people aged less than 60 years.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Liu J,Wang G,Peng Zdoi
10.1155/2020/5190587subject
Has Abstractpub_date
2020-05-20 00:00:00pages
5190587eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章,评审abstract::Vitamin D deficiency is common in pregnant women and infants. The present study aimed to investigate the effects of vitamin D restricted diet on the Wistar rats offspring penis morphology. Mother rats received either standard diet (SC) or vitamin D restricted (VitD) diet. At birth, offspring were divided into SC/SC (f...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6030646
更新日期:2018-04-23 00:00:00
abstract::Many topical agents are available for treating the acute phase of acne; however, few agents have been proven beneficial during the maintenance phase. Objective. To evaluate the efficacy and safety of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid during the maintenance phase of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2857812
更新日期:2020-10-16 00:00:00
abstract:Objective:To determine if increasing variability of blood pressure influences determination of cerebral autoregulation. Methods:A prospective observational study was performed at the ICU of a university hospital in the Netherlands. 13 comatose patients after cardiac arrest underwent baseline and intervention (tilting ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8153241
更新日期:2018-06-06 00:00:00
abstract::Adiponectin (APN) is an adipokine secreted from adipose tissue and exhibits biological functions such as microcirculation-regulating, hearing-protective, and antiapoptotic. However, the effect of APN on the apoptosis of spiral arterial smooth muscle cells (SMCs) under hypoxic conditions in vitro is not clear. We used ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7169348
更新日期:2020-10-10 00:00:00
abstract::Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long no...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/2405351
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abstract::Coconut palm (Cocos nucifera) is an important commercial crop in many tropical countries, but its industry generates large amounts of residue. One way to address this problem is to use this residue, coconut husk, to produce second-generation (2G) ethanol. The aim of this review is to describe the methods that have bee...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4916497
更新日期:2018-09-27 00:00:00
abstract::Intervertebral disk disease (IVDD) is a major spine disorder in canines that causes neurological dysfunction, particularly in the thoracolumbar area. Analgesic and anti-inflammatory drugs are typically used to reduce nociceptive signals to decrease canine suffering. Bee venom (BV) has been reported to exert anti-infla...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) is a complex disease, resulting from proliferation of differentially arrested immature T cells. The molecular mechanisms and the genes involved in the generation of T-ALL remain largely undefined. In this study, we propose a set of genes to differentiate individuals with T-A...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2013/210253
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/183523
更新日期:2015-01-01 00:00:00
abstract::Craniofacial reconstruction is to estimate a person's face model from the skull. It can be applied in many fields such as forensic medicine, archaeology, and face animation. Craniofacial reconstruction is based on the relationship between the skull and the face to reconstruct the facial appearance from the skull. Howe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8835179
更新日期:2020-12-04 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8718097
更新日期:2020-08-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5239082
更新日期:2018-06-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/646347
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/945169
更新日期:2014-01-01 00:00:00
abstract::Recent studies suggest that nucleotide-binding domain leucine-rich repeat protein 1 (NLRP1) is a pivotal factor in the inflammatory process. However, the role of NLRP1 in breast cancer pathogenesis remains unclear. The aim of this study was to examine the expression and function of NLRP1 in breast cancer. We found tha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4938473
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/914791
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:An elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be associated with a poor prognosis in several cancers. We evaluated the utility of an elevated NLR as a biomarker to predict the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients treated with ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7538647
更新日期:2017-01-01 00:00:00
abstract::This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The gene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/523415
更新日期:2013-01-01 00:00:00
abstract::Introduction. Infection and apoptosis are combined triggers for inflammation in dental tissues. Octamer-binding transcription factor 4-B1 (OCT4B1), a novel spliced variant of OCT4 family, could respond to the cellular stress and possess antiapoptotic property. However, its specific role in dental pulpitis remains unkn...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2756891
更新日期:2017-01-01 00:00:00
abstract::Objective. To evaluate the efficacy of bundle intervention on healthcare-associated (HA) methicillin-resistant Staphylococcus Aureus (MRSA) infection in the neonatal intensive care unit (NICU). Methods. In this study, 11,277 infants having undergone treatment at the NICU in Xiamen, China, from January 2014 to February...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5490413
更新日期:2019-07-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/303298
更新日期:2014-01-01 00:00:00
abstract::Aim. To investigate the expression of miR-940 in the hepatocellular carcinoma (HCC) and its impact on function and biological mechanism in the HCC cells. Methods. Quantitative RT-PCR analysis was used to quantify miR-940 expression in 46 cases of tissues and cells. Transfection of HCC cell lines was performed by miR-9...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7618342
更新日期:2016-01-01 00:00:00
abstract:Introduction:An increased number of survivors have emerged from the 2014 West African Ebola Virus Disease (EVD) epidemic. Post-Ebola Syndrome (PES) is a group of physical and psychological symptoms affecting EVD survivors. This study aimed to estimate the prevalence of PES among EVD survivors in Montserrado County, Lib...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1909410
更新日期:2018-06-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2876135
更新日期:2018-02-27 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/154549
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4759060
更新日期:2019-07-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/563756
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2015/618021
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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