Abstract:
:Aim. To investigate the expression of miR-940 in the hepatocellular carcinoma (HCC) and its impact on function and biological mechanism in the HCC cells. Methods. Quantitative RT-PCR analysis was used to quantify miR-940 expression in 46 cases of tissues and cells. Transfection of HCC cell lines was performed by miR-940 mimics; the abilities of invasion and migration were assessed through Transwell array. Western blot represents the alteration in expression of CXCR2 by miR-940 mimics. Results. miR-940 expression was decreased significantly in the HCC tissues and the relevant cell lines. miR-940 upregulation suppressed the invasion and migration of HCC cells in vitro. Furthermore, the CXCR2 was downregulated to suppress invasion and migration after miR-940 mimics. Moreover, decreased miR-940 expression was negatively correlated with Edmondson grade (P = 0.008), tumor microsatellite or multiple tumors (P = 0.04), vascular invasion (P = 0.035), and recurrence and metastasis (P = 0.038). Kaplan-Meier analysis demonstrated that decreased miR-940 expression contributed to poor overall survival (P < 0.05). Conclusions. Our findings present that miR-940 acts as a pivotal adaptor of CXCR2 and its transcription downregulated CXCR2 expression to decrease HCC invasion and migration in vitro. Our study suggests that miR-940 may be a novel poor prognostic biomarker for HCC.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Ding D,Zhang Y,Yang R,Wang X,Ji G,Huo L,Shao Z,Li Xdoi
10.1155/2016/7618342subject
Has Abstractpub_date
2016-01-01 00:00:00pages
7618342eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章abstract::Optical molecular imaging, a new medical imaging technique, is developed based on genomics, proteomics and modern optical imaging technique, characterized by non-invasiveness, non-radiativity, high cost-effectiveness, high resolution, high sensitivity and simple operation in comparison with conventional imaging modali...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/429198
更新日期:2014-01-01 00:00:00
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doi:10.1155/2013/140327
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journal_title:BioMed research international
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doi:10.1155/2014/187989
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abstract::[This corrects the article DOI: 10.1155/2015/587135.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/3017536
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abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary mic...
journal_title:BioMed research international
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abstract::Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. However, how GABA level varies with age in the medial portion of the brain has not yet been studied. The purpose of this study was to investigate the GABA level var...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6523909
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/748160
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4250329
更新日期:2020-07-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8798546
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/917640
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/239838
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3859582
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/895401
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/453469
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1310342
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/161346
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/251354
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052143
更新日期:2020-08-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/354906
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7636290
更新日期:2020-01-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/927685
更新日期:2014-01-01 00:00:00
abstract::Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/549785
更新日期:2014-01-01 00:00:00
abstract::Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, inclu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/916136
更新日期:2013-01-01 00:00:00
abstract:Objective:Mounting evidence has elaborated the implication of long noncoding RNAs (lncRNAs) in tumorigenesis of several cancers, including glioma. However, little was known about the mechanism of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of glioma. This work is designed to explore the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4309161
更新日期:2020-01-11 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in TNFSF4 and ANKRD55 genes have been shown to be associated with several autoimmune diseases, although whether these genes are susceptibility genes for dermatomyositis/polymyositis (DM/PM) has, to date, not been reported. This study aimed to investigate the potential association...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2905987
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/150653
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/342529
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/382891
更新日期:2014-01-01 00:00:00