Abstract:
:A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solvent by heat-initiated free radical method. The obtained macromonomers and hydrogels were characterized by ¹H NMR and FT-IR, respectively. Morphology study of hydrogels was also investigated in this paper, and it showed that the hydrogels had good pH-sensitivity. The acute toxicity test and histopathological study were conducted in BALB/c mice. The results indicated that the maximum tolerance dose of the hydrogel was higher than 10,000 mg/kg body weight. No morality or signs of toxicity were observed during the whole 7-day observation period. Compared to the control groups, there were no important adverse effects in the variables of hematology routine test and serum chemistry analysis both in male or female treatment group. Histopathological study also did not show any significant lesions, including heart, liver, lung, spleen, kidney, stomach, intestine, and testis. All the results demonstrated that this hydrogel was nontoxic after gavage. Thus, the hydrogel might be the biocompatible potential candidate for oral drug delivery system.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Tan L,Xu X,Song J,Luo F,Qian Zdoi
10.1155/2013/239838subject
Has Abstractpub_date
2013-01-01 00:00:00pages
239838eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::There has been no previous study using three-dimensional (3D) measurement on femoral tunnel characteristics according to the combined influence of various flexion angles of knee and transverse drill angles in single-bundle ACL reconstruction with transportal technique. The purpose of this study was to determine optima...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2643247
更新日期:2018-07-17 00:00:00
abstract::Professional phagocytic cells, such as dendritic cells, are mainly responsible for phagocytosis, antigen presentation, and cytokine secretion, which induce subsequent activation of T cell-mediated immunity. Thus, strategies that deliver antigens and stimulatory signals to the cells have significant implications for va...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/562924
更新日期:2013-01-01 00:00:00
abstract::Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2019/5897505
更新日期:2019-07-28 00:00:00
abstract::Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/782625
更新日期:2014-01-01 00:00:00
abstract:Objectives:To evaluate the effects of pentobarbital dosages on lower urinary tract function and to define an appropriate dosage of sodium pentobarbital that would be suitable for urodynamic studies in which recovery from anesthesia and long term survive were needed for subsequent experiment. Methods:Twenty-four 8-week...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6109497
更新日期:2020-06-11 00:00:00
abstract:Objective:To evaluate the performance of contrast-enhanced mammography (CEM) compared to magnetic resonance imaging (MRI) for estimating residual tumor size after neoadjuvant chemotherapy (NAC) in women with newly diagnosed breast cancer. Methods:The institutional review board approved this study. This prospective stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8531916
更新日期:2018-11-08 00:00:00
abstract::This work evaluated the physicochemical properties and antioxidant activity of spray dried extracts (SDE) from Psidium guajava L. leaves. Different drying carriers, namely, maltodextrin, colloidal silicon dioxide, Arabic gum, and β -cyclodextrin at concentrations of 40 and 80% relative to solids content, were added to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/382891
更新日期:2014-01-01 00:00:00
abstract::The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can mod...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/271276
更新日期:2013-01-01 00:00:00
abstract:Background:As the important components in polycomb repressive complexes 1 (PRC1) and heterochromatin protein 1 (HP1), Chromobox (CBX) family members are involved in epigenetic regulatory function, transcriptional repression, and other cellular metabolisms. Increasing studies have indicated significant associations betw...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5306509
更新日期:2020-11-05 00:00:00
abstract::[This corrects the article DOI: 10.1155/2013/783690.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/8693826
更新日期:2016-01-01 00:00:00
abstract:Objectives:The mortality rate of patients with acute respiratory distress syndrome (ARDS) is high. Hence, it is crucial to identify a reliable biomarker with wide clinical applications for predicting the prognosis of patients with ARDS. This systematic review and meta-analysis was conducted to investigate the value of ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2020/3472615
更新日期:2020-04-05 00:00:00
abstract::In the present study, we determined whether there is a delay in the eruption of permanent teeth (PT) among Filipino adolescents with stunting or thinness. Height, weight, and number of PT were recorded in 1554 Filipino 10- to 13-year-olds (711 boys; 843 girls). z-scores for height (HAZ) and body mass index (BMI) were ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/205950
更新日期:2013-01-01 00:00:00
abstract::Melanoma is a human skin malignant tumor with high invasion and poor prognosis. The limited understanding of genomic alterations in melanomas in China impedes the diagnosis and therapeutic strategy selection. We conducted comprehensive genomic profiling of melanomas from 39 primary and metastatic formalin-fixed paraff...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6096814
更新日期:2020-01-30 00:00:00
abstract::The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6492183
更新日期:2016-01-01 00:00:00
abstract::Background. For development of individualized treatment on a routine basis, transfer of patients' tumor tissue in a xenograft model (i.e., generation of patient-derived xenografts (PDX)) is desirable for molecular, biochemical, or functional analyses. Drawbacks are dissatisfactory tumor take rates, the necessity of fa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1715053
更新日期:2016-01-01 00:00:00
abstract::Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/145619
更新日期:2014-01-01 00:00:00
abstract::Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/143504
更新日期:2015-01-01 00:00:00
abstract::Ultrasonography has been widely employed to estimate the morphological changes of muscle during contraction. To further investigate the motion pattern of quadriceps during isometric knee extensions, we studied the relative motion pattern between femur and quadriceps under ultrasonography. An interesting observation is...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6385315
更新日期:2018-03-18 00:00:00
abstract::Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/179568
更新日期:2014-01-01 00:00:00
abstract::This study applies the environmental Kuznets curve to test the relationship between the regional economic growth and the different types of agricultural nonpoint source pollution loads in the Ningxia Yellow River irrigation area by using the Johnes export coefficient method. Results show that the pollution load genera...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/267968
更新日期:2013-01-01 00:00:00
abstract::The relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) has attracted wide attention. Studies have reported that ginsenoside Rb1 can improve human cognitive ability and glucose tolerance during the development of diabetes. The mechanism behind the improvement in cognitive ability and glucose toler...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3905719
更新日期:2020-05-20 00:00:00
abstract::DNA Primase Subunit 1 (PRIM1) is crucial for cancer development and progression. However, there remains a lack of comprehension concerning the clinical implication of PRIM1 in HCC. Here, aberrant expression of PRIM1 was identified in HCC according to available databases. The prognostic value of PRIM1 in patients prese...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9689312
更新日期:2020-08-22 00:00:00
abstract::This study compares the effects of team-sport training, for sedentary men with lifestyle diseases, with fitness training in a pragmatic set-up in a community health centre (CHC). Thirty-two men in the fitness group (FiG) and 36 men in the team-sport group (TsG) completed the training and trained for 60-90 min, two tim...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1571807
更新日期:2018-05-15 00:00:00
abstract::Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4060728
更新日期:2018-05-31 00:00:00
abstract::Besides the pinpointing of individual disease-related genes, associating protein complexes to human inherited diseases is also of great importance, because a biological function usually arises from the cooperative behaviour of multiple proteins in a protein complex. Moreover, knowledge about disease-related protein co...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/732650
更新日期:2013-01-01 00:00:00
abstract::Magnetic resonance imaging (MRI) based on the ferritin heavy chain 1 (FTH1) reporter gene has been used to trace stem cells. However, whether FTH1 expression is affected by stem cell differentiation or whether cell differentiation is affected by reporter gene expression remains unclear. Here, we explore the relationsh...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1978602
更新日期:2018-06-26 00:00:00
abstract:OBJECTIVE:This study evaluated the frequencies of allergic symptoms and rate of upper respiratory infections during the past year in the general population, kitchen workers (KW) and health care workers (HCW). METHODS:The European Community Respiratory Health Survey (ECRHS) was used to inquire retrospectively about ast...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/285420
更新日期:2013-01-01 00:00:00
abstract:Background:The Biodex Biosway® Balance System and SWAY Balance® Mobile smartphone application (SBMA) are portable instruments that assess balance function with force plate and accelerometer technology, respectively. The validity of these indirect clinical measures of postural sway merits investigation. Purpose:The pur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8185710
更新日期:2019-12-21 00:00:00
abstract::Giardia duodenalis, is often seen as an opportunistic pathogen and one of the major food and waterborne parasites. Some insights of Giardia infestation in a diarrhoea-prone population were investigated in the present study. Our primary goal was to understand the interaction of this parasite with other pathogens during...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/786480
更新日期:2014-01-01 00:00:00
abstract:Background:As a newly discovered lncRNA, bladder cancer-associated transcript 1 (BLACAT1) has been reported to correlate with poor clinical outcomes in several different cancers. This study aimed to evaluate its generalized predictive value for cancer prognosis. Materials and Methods:We thoroughly searched PubMed, Emb...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/1275491
更新日期:2019-04-02 00:00:00