Abstract:
:DNA Primase Subunit 1 (PRIM1) is crucial for cancer development and progression. However, there remains a lack of comprehension concerning the clinical implication of PRIM1 in HCC. Here, aberrant expression of PRIM1 was identified in HCC according to available databases. The prognostic value of PRIM1 in patients presenting with HCC was further assessed based on TCGA data. Gene set enrichment analysis (GSEA) was subsequently conducted to investigate the potential function of PRIM1. Additionally, the correlations between tumor-infiltrating immune cells (TIICs) and PRIM1 expression were evaluated. The data from TCGA, GEO, ONCOMINE, and HCCDB databases illustrated that PRIM1 was overexpressed in HCC tissues, compared to normal liver tissues (all p < 0.05). Kaplan-Meier analysis revealed that high PRIM1 expression in HCC was closely correlated with worse overall survival (p < 0.05). The univariate and multivariate analyses illustrated that PRIM1 expression was an independent novel prognostic indicator in HCC. Additionally, the area under the receiver operating characteristic (AUROC) curve for PRIM1 reached 0.8651, indicating the diagnostic significance of PRIM1 in patients with HCC. GSEA showed that PRIM1 overexpression was significantly enriched in several tumor-related signaling pathways. Besides, TIIC analysis clarified the association between PRIM1 expression and TIICs in HCC. The findings disclose that PRIM1 profoundly implicated in promoting tumorigenesis might work as a desirable biomarker for HCC.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhang Y,Li L,Liu R,Zeng Cdoi
10.1155/2020/9689312subject
Has Abstractpub_date
2020-08-22 00:00:00pages
9689312eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6452965
更新日期:2018-10-25 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8582901
更新日期:2018-05-02 00:00:00
abstract::Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. They attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. The formation of neutrophil extracellular traps (NETs) is the thir...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4192745
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of two foot placements (normal or posterior placement) and three arm positions (hands on the thighs, arms crossed over chest, and augmented arm position with elbow extended) on the five times sit-to-stand (FTSTS) test times of individuals with chronic stroke. DESIGN:Cross-sectional...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/636530
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4094191
更新日期:2020-06-20 00:00:00
abstract::Aerobic granulation of activated sludge was successfully achieved in a full-scale sequencing batch reactor (SBR) with 50,000 m(3) d(-1) for treating a town's wastewater. After operation for 337 days, in this full-scale SBR, aerobic granules with an average SVI30 of 47.1 mL g(-1), diameter of 0.5 mm, and settling veloc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/268789
更新日期:2014-01-01 00:00:00
abstract::We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraper...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/526367
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5184595
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4217076
更新日期:2019-03-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9037693
更新日期:2020-04-30 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/457473
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/898719
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8403642
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6507350
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2543262
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9743075
更新日期:2020-10-09 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/780752
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6316059
更新日期:2018-07-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3178784
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1703842
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7610387
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7530653
更新日期:2018-12-16 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2947067
更新日期:2020-12-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/976362
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7614634
更新日期:2020-07-25 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/4039173
更新日期:2018-11-14 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1030256
更新日期:2019-11-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/835081
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3859582
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/121030
更新日期:2013-01-01 00:00:00