Abstract:
Objective:To evaluate the performance of contrast-enhanced mammography (CEM) compared to magnetic resonance imaging (MRI) for estimating residual tumor size after neoadjuvant chemotherapy (NAC) in women with newly diagnosed breast cancer. Methods:The institutional review board approved this study. This prospective study included women with newly diagnosed breast cancer who underwent breast CEM and MRI at the end of the last cycle of NAC and before definitive surgery. Size of residual malignancy on post-NAC CEM and MRI was compared with surgical pathology. Agreements and correlations of CEM and MRI measurements with histological size were assessed. Results:Thirty-three patients were included with a mean age of 45 years (range 22-76). The sensitivity, specificity, and positive and negative predictive value for detection of residual disease of CEM were 76%, 87.5%, 95%, and 86.4%, and those of MRI were 92%, 75%, 92%, and 75%. Comparing CEM to MRI, the mean difference was -0.8 cm, concordance coefficient was 0.7, and Pearson correlation was 0.7 (p = 0.0003). The concordance coefficient between measurements of each imaging modality and pathologic tumor size was 0.7 for CEM and 0.4 for MRI. Pearson correlation was 0.8 for CEM and 0.5 for MRI. Mean differences between CEM, MRI, and residual histopathological tumor size were 0.8 cm and 1.8 cm, respectively. Conclusions:CEM has good correlation and agreement with histopathology for measuring residual disease after NAC. CEM was comparable to MRI, showing high positive predictive value and specificity for detecting residual disease.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Barra FR,Sobrinho AB,Barra RR,Magalhães MT,Aguiar LR,de Albuquerque GFL,Costa RP,Farage L,Pratesi Rdoi
10.1155/2018/8531916subject
Has Abstractpub_date
2018-11-08 00:00:00pages
8531916eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Parents' birth weight acts as a predictor for the descendant birth weight, with the correlation more strongly transmitted through maternal line. The present research aims to study the correlation between the child's low or increased birth weight, the mother's birth weight, and maternal conditi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/615034
更新日期:2015-01-01 00:00:00
abstract::Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2854736
更新日期:2016-01-01 00:00:00
abstract::Early recovery from muscular injury is crucial for elite athletes. Hyperbaric oxygen therapy (HBOT) has been reported to be beneficial in terms of accelerating cell recovery and tissue repair, which are considered to be helpful for eliminating fatigue and recovering stamina. This study was performed to evaluate the ef...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/6289380
更新日期:2019-05-29 00:00:00
abstract::Few studies assess agreement among Schistosoma haematobium eggs, measured hematuria, and self-reported metrics. We assessed agreement among four metrics at a single time point and analyzed the stability of infection across two time points with a single metric. We used data from the Eastern Region of Ghana and construc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7627358
更新日期:2016-01-01 00:00:00
abstract::There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD). Stress-related dysregulation of the sympathetic and parasympathetic system and the hypothalamic pituitary adrenal (HPA) axis may explain the enhanced risk for CVD. To test this hypothesis, 55 patients (34 males and 21 females) w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/431725
更新日期:2015-01-01 00:00:00
abstract::Taenia solium thioredoxin-1 gene (TsTrx-1) has a length of 771 bp with three exons and two introns. The core promoter gene presents two putative stress transcription factor binding sites, one putative TATA box, and a transcription start site (TSS). TsTrx-1 mRNA is expressed higher in larvae than in adult. This gene en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/453469
更新日期:2015-01-01 00:00:00
abstract::The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9395146
更新日期:2019-12-28 00:00:00
abstract:Background:Flaviviridae viruses are single-stranded, positive-sense RNA viruses, which threat human constantly mediated by mosquitoes, ticks, and sandflies. Considering the recent increase in the prevalence of the family virus and its risk potential, we investigated the codon usage pattern to understand its evolutionar...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5857285
更新日期:2019-06-27 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/6353510.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/5189346
更新日期:2018-09-26 00:00:00
abstract:BACKGROUND:Although binge drinking prevalence and correlates among young people have been extensively studied in the USA and Northern Europe, less is known for Southern Europe countries with relatively healthier drinking cultures. OBJECTIVE:We aimed at analyzing prevalence and correlates of binge drinking in a represe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/930795
更新日期:2014-01-01 00:00:00
abstract:Objective:Hepatitis B virus (HBV) causes inflammation of the liver and is the leading cause of both liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Serine protease inhibitor Kazal type 1 (SPINK1) is an acute-phase response protein that is overexpressed in liver cancer tissue. This study investigated the clinic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9321494
更新日期:2019-05-22 00:00:00
abstract:PURPOSE:To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS:Institutional review board approval...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/835385
更新日期:2013-01-01 00:00:00
abstract::One of the most common complications of diabetes mellitus is diabetic neuropathy. It may be provoked by metabolic and/or vascular factors, and depending on duration of disease, various layers of nerve may be affected. Our aim was to investigate influence of diabetes on the epineurial, perineurial, and endoneurial conn...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/870930
更新日期:2014-01-01 00:00:00
abstract::Bacteria are a source of a large number of secondary metabolites with several biomedical and biotechnological applications. In recent years, there has been tremendous progress in the development of novel synthetic biology approaches both to increase the production rate of secondary metabolites of interest in native pr...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/7021826
更新日期:2018-07-09 00:00:00
abstract::Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/436242
更新日期:2014-01-01 00:00:00
abstract:Purpose:To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods:Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3684971
更新日期:2017-01-01 00:00:00
abstract::Progression of idiopathic dilated cardiomyopathy (IDCM) is marked with extensive left ventricular remodeling whose clinical manifestations and molecular basis are poorly understood. We aimed to evaluate the clinical potential of titin ligands in monitoring progression of cardiac remodeling associated with end-stage ID...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/273936
更新日期:2015-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal condition primarily characterized by the selective loss of upper and lower motor neurons. At present, the diagnosis and monitoring of ALS is based on clinical examination, electrophysiological findings, medical history, and exclusion of confounding disorders. There is the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/525097
更新日期:2014-01-01 00:00:00
abstract::Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/421746
更新日期:2015-01-01 00:00:00
abstract::Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/739010
更新日期:2013-01-01 00:00:00
abstract::DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4590609
更新日期:2017-01-01 00:00:00
abstract::Inorganic arsenic (iAs) exposure induces a decrease in glucose type 4 transporter (GLUT4) expression on the adipocyte membrane, which may be related to premature births and low birth weight infants in women exposed to iAs at reproductive age. The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/175025
更新日期:2015-01-01 00:00:00
abstract:Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7147824
更新日期:2020-07-31 00:00:00
abstract:Objective:To determine if increasing variability of blood pressure influences determination of cerebral autoregulation. Methods:A prospective observational study was performed at the ICU of a university hospital in the Netherlands. 13 comatose patients after cardiac arrest underwent baseline and intervention (tilting ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8153241
更新日期:2018-06-06 00:00:00
abstract::The rapid development of picture archiving and communication systems (PACSs) thoroughly changes the way of medical informatics communication and management. However, as the scale of a hospital's operations increases, the large amount of digital images transferred in the network inevitably decreases system efficiency. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/657417
更新日期:2014-01-01 00:00:00
abstract::Genome-wide association studies (GWAS) have extensively analyzed single SNP effects on a wide variety of common and complex diseases and found many genetic variants associated with diseases. However, there is still a large portion of the genetic variants left unexplained. This missing heritability problem might be due...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/671859
更新日期:2015-01-01 00:00:00
abstract::Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophyla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/807196
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. METHODS:Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair a...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/709452
更新日期:2015-01-01 00:00:00
abstract::We compared the performances of 3 Multiple Allergen Simultaneous Test (MAST) assays: RIDA Allergy Screen (R-Biopharm, Darmstadt, Germany), MAST Optigen allergy system (Hitachi Chemical Diagnostics, Mountain View, CA), and Polycheck Allergy (Biocheck GmbH, Munster, Germany). Forty sera that tested positive with the RID...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/340513
更新日期:2013-01-01 00:00:00
abstract::Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/839761
更新日期:2013-01-01 00:00:00