Abstract:
:Many topical agents are available for treating the acute phase of acne; however, few agents have been proven beneficial during the maintenance phase. Objective. To evaluate the efficacy and safety of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid during the maintenance phase of mild to moderate acne in Thai patients. Methods. One hundred and ten patients with mild to moderate acne vulgaris were initially treated with a fixed combination of adapalene 0.1%/benzoyl peroxide 2.5% gel once daily for 8 weeks. Fifty patients who achieved at least 50% reduction in lesion counts or at least a 2-grade improvement in the Investigator's Global Assessment (IGA) grade from baseline were enrolled in the maintenance phase, which was an investigator-masked, left-right comparison, randomized, controlled, intraindividual study. Moisturizers with and without the active study ingredients were applied twice a day to each side of the face, respectively, for 12 weeks. Assessments included acne lesion counts, acne severity by IGA scoring, skin bioengineering measurements, and skin tolerability as assessed by both patient and physician. Results. The treatment group had a significant reduction in the mean counts of noninflammatory, inflammatory, and total lesions compared to the vehicle group at week 12 and also between baseline and week 12. There was no significant difference in the mean scores for skin dryness, stinging/burning, or pruritus at any time point between groups. Conclusions. Moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid reduced acne lesions and prevented the development of new lesions during the maintenance phase. This trial is registered with ClinicalTrials.gov registration no. NCT04002024.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kulthanan K,Trakanwittayarak S,Tuchinda P,Chularojanamontri L,Limphoka P,Varothai Sdoi
10.1155/2020/2857812subject
Has Abstractpub_date
2020-10-16 00:00:00pages
2857812eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract:OBJECTIVE:To evaluate the efficacy and safety of docetaxel plus oxaliplatin and capecitabine (DOX) in the first line treatment of advanced gastric adenocarcinoma. METHODS:A total of 37 patients were enrolled into this study, and they received DOX regimen (docetaxel 75 mg/m² and oxaliplatin 130 mg/m² intravenous infusi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/971096
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To identify an effective method to prevent myopia progression by characterizing the regulation of matrix metalloproteinase- (MMP-) 2 expression and its secretion from scleral fibroblasts and retinal pigment epithelium (RPE) cells by miR-29a. METHODS:The effects of miR-29a on the growth of scleral fibroblasts a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2647879
更新日期:2017-01-01 00:00:00
abstract::The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after surgery. 38 patients with prostate cancer were included. miR-21 and miR-141 were quant...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/241780
更新日期:2013-01-01 00:00:00
abstract::The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/537941
更新日期:2014-01-01 00:00:00
abstract::We developed a computational method to identify NAD- and FAD-binding sites in proteins. First, we extracted from the Protein Data Bank structures of proteins that bind to at least one of these ligands. NAD-/FAD-binding residue templates were then constructed by identifying binding residues through the ligand-binding d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/402536
更新日期:2015-01-01 00:00:00
abstract::Both human adipose tissue-derived mesenchymal stem cells (ASCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been explored as attractive mesenchymal stem cells (MSCs) sources, but very few parallel comparative studies of these two cell types have been made. We designed a side-by-side comparative st...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版
doi:10.1155/2013/438243
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Residual neuromuscular block (NMB) after general anesthesia has been associated with pulmonary dysfunction and hypoxia, which are both associated with postoperative delirium (POD). We evaluated the effects of sugammadex on POD in elderly patients who underwent hip fracture surgery. METHODS:Medical records o...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/1054597
更新日期:2016-01-01 00:00:00
abstract::This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6758017
更新日期:2019-12-07 00:00:00
abstract::Sun Island Bund Wetland (SIBW) is a river floodplain wetland located at the south part of Heilongjiang Province in Northeast China. An investigation of the influence of habitat type on macroinvertebrates assemblages structure was conducted in July 2016. Nine (9) sampling sites were selected based on sediment type, wat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2650678
更新日期:2019-02-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3757149
更新日期:2019-11-29 00:00:00
abstract::Abdominal pregnancy is a very rare form of ectopic pregnancy, associated with high morbidity and mortality for both fetus and mother. It is, and often, seen in poor resource nations, where early diagnosis is often a major challenge due to poor prenatal care and lack of medical resources. An advanced abdominal pregnanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/102479
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/2643862.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2017/5782619
更新日期:2017-01-01 00:00:00
abstract::Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. However, how GABA level varies with age in the medial portion of the brain has not yet been studied. The purpose of this study was to investigate the GABA level var...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6523909
更新日期:2016-01-01 00:00:00
abstract::The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/810734
更新日期:2013-01-01 00:00:00
abstract::We performed a retrospective review of 40 consecutive modern cementless THAs with 65-month mean followup in 34 patients under the age of 30 primarily for diagnoses other than inflammatory arthritis. We found acceptable functional improvement and radiographic outcomes at mean 5-year followup. We found a high transfusio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/649506
更新日期:2013-01-01 00:00:00
abstract::Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2494067
更新日期:2017-01-01 00:00:00
abstract:Background:Oxycodone is a widely used opioid analgesic, which is involved in cancer pain and non-cancer pain. This study is intended to understand the publication characteristics of oxycodone research field and assess the quality of pertinent articles from 1998 to 2017. Methods:Oxycodone-related publications from 1998...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9096201
更新日期:2019-10-31 00:00:00
abstract::After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/835081
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to offer a new insight into the microstructure changes during in vitro lipolysis of five lipid-based drug delivery formulations belonging to different lipid formulation types. Five lipid-based formulations of indomethacin were investigated using an in vitro lipolysis model. During lipolys...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2364317
更新日期:2016-01-01 00:00:00
abstract::To protect against the environmental pollution, the present research was undertaken to enumerate the Bacterial Technologies (BTs) on the restoration of polluted urban rivers, that is, Fenghu-Song Yang River (FSR) and Xuxi River (XXR). Experimental research accounted for the physiochemical parameters (pH; temperature; ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/241769
更新日期:2015-01-01 00:00:00
abstract::A metabolic disorder is considered one of the hallmarks of cancer. Multiple differentially expressed metabolic genes have been identified in colon cancer (CC), and their biological functions and prognostic values have been well explored. The purpose of the present study was to establish a metabolic signature to optimi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4845360
更新日期:2020-11-17 00:00:00
abstract::Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- α therapy was found to be effecti...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/860651
更新日期:2014-01-01 00:00:00
abstract::WNT proteins are involved in embryonic development, sex determination, stem cell recruitment, angiogenesis, and cancer. They take part in morphological changes in the endometrium during development, regulate processes of endometrial proliferation and differentiation. This review presents current knowledge about implic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/854056
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To investigate the correlation of outer retinal layers (ORL) thickness and visual acuity (VA) in patients with diabetic macular edema (DME). METHODS:Consecutive DME patients seen at the Retina Clinic of The University of Hong Kong were recruited for OCT assessment. The ORL thickness was defined as the distance...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/981471
更新日期:2015-01-01 00:00:00
abstract::In renal cell carcinoma, chromophobe renal cell carcinoma (ChRCC) is a distinct subtype, whose clinical manifestations often lack specificity, and the molecular mechanisms of ChRCC tumorigenesis remain generally vague. The target of this study was to discover novel biomarkers involved in ChRCC by integrated bioinforma...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2671281
更新日期:2020-02-07 00:00:00
abstract:Objective:To evaluate the performance of contrast-enhanced mammography (CEM) compared to magnetic resonance imaging (MRI) for estimating residual tumor size after neoadjuvant chemotherapy (NAC) in women with newly diagnosed breast cancer. Methods:The institutional review board approved this study. This prospective stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8531916
更新日期:2018-11-08 00:00:00
abstract::There is an emerging body of evidence that chemoresistance and minimal residual disease result from selective resistance of a cell subpopulation from the original tumor that is molecularly and phenotypically distinct. These cells are called "cancer stem cells" (CSCs). In this review, we analyze the potential targeting...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/859871
更新日期:2014-01-01 00:00:00
abstract::Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/121254
更新日期:2014-01-01 00:00:00
abstract::Cerenkov luminescence imaging (CLI) can provide information of medical radionuclides used in nuclear imaging based on Cerenkov radiation, which makes it possible for optical means to image clinical radionuclide labeled probes. However, the exceptionally weak Cerenkov luminescence (CL) from Cerenkov radiation is suscep...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7948432
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/2580969
更新日期:2016-01-01 00:00:00