Abstract:
BACKGROUND:Residual neuromuscular block (NMB) after general anesthesia has been associated with pulmonary dysfunction and hypoxia, which are both associated with postoperative delirium (POD). We evaluated the effects of sugammadex on POD in elderly patients who underwent hip fracture surgery. METHODS:Medical records of 174 consecutive patients who underwent hip fracture surgery with general anesthesia were reviewed retrospectively to compare the perioperative incidence of POD, pulmonary complications, time to extubation, incidence of hypoxia, and laboratory findings between patients treated with sugammadex and those treated with a conventional cholinesterase inhibitor. RESULTS:The incidence of POD was not significantly different between the two groups (33.3% versus 36.5%, resp.; P = 0.750). Postoperative pulmonary complications and laboratory findings did not showed significant intergroup difference. However, time to extubation (6 ± 3 versus 8 ± 3 min; P < 0.001) and the frequency of postoperative hypoxia were significantly lower (23% versus 43%; P = 0.010) in the sugammadex group than in the conventional cholinesterase inhibitor group. CONCLUSION:Sugammadex did not reduce POD or pulmonary complications compared to conventional cholinesterase inhibitors, despite reducing time to extubation and postoperative hypoxia in elderly patients who underwent hip fracture surgery under general anesthesia.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Oh CS,Rhee KY,Yoon TG,Woo NS,Hong SW,Kim SHdoi
10.1155/2016/1054597subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1054597eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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