Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice.

abstract：:Giardia duodenalis is a small intestinal protozoan parasite of several terrestrial vertebrates. This work aims to assess the genotypic variability of Giardia duodenalis isolates from cattle, sheep and pigs in the Southeast of Brazil, by comparing the standard characterization between glutamate dehydrogenase (gdh) and ...

journal_title：BioMed research international

authors： Fava NM,Soares RM,Scalia LA,Kalapothakis E,Pena IF,Vieira CU,Faria ES,Cunha MJ,Couto TR,Cury MC

更新日期：2013-01-01 00:00:00

abstract：Aim:Little is known about the association between cancer antigen 125 (MUC16/CA125) concentrations and tumor diameter of patients with hepatocellular carcinoma (HCC) and low AFP levels. To fill this gap in our knowledge, we conducted a retrospective study of 427 patients with HCC with AFP ≤200 ng/mL who underwent R0 res...

journal_title：BioMed research international

authors： Zhou S,Wang Z,Li M,Wu L

更新日期：2019-09-29 00:00:00

abstract：:The present study evaluated the anti-inflammatory and analgesic effects of the superoxide dismutase mimetic agent tempol in superoxide anion-induced pain and inflammation. Mice were treated intraperitoneally with tempol (10-100 mg/kg) 40 min before the intraplantar injection of a superoxide anion donor, potassium supe...

journal_title：BioMed research international

authors： Bernardy CCF,Zarpelon AC,Pinho-Ribeiro FA,Calixto-Campos C,Carvalho TT,Fattori V,Borghi SM,Casagrande R,Verri WA Jr

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Firstly, to, through instrumentation with the iPhone4 smartphone, measure and describe variability of tridimensional acceleration, angular velocity, and displacement of the trunk in the turn transition during the ten-meter Extended Timed-Get-up-and-Go test in two groups of frail and physically active elderly ...

journal_title：BioMed research international

authors： Galán-Mercant A,Cuesta-Vargas AI

更新日期：2013-01-01 00:00:00

abstract：:Antipsychotic drugs (APDs) used to treat clinical psychotic syndromes cause a variety of blood dyscrasias. APDs suppress the aggregation of platelets; however, the underlying mechanism remains unknown. We first analyzed platelet aggregation and clot formation in platelets treated with APDs, risperidone, clozapine, or ...

journal_title：BioMed research international

authors： Wu CC,Tsai FM,Chen ML,Wu S,Lee MC,Tsai TC,Wang LK,Wang CH

更新日期：2016-01-01 00:00:00

abstract：:Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and pre...

journal_title：BioMed research international

authors： Lin WC,Tsai NW,Huang YC,Cheng KY,Chen HL,Li SH,Kung CT,Su YJ,Lin WM,Chen MH,Chiu TM,Yang IH,Lu CH

更新日期：2014-01-01 00:00:00

abstract：:It is unclear whether the methyltransferase-like 14 (METTL14) protein promotes or suppresses cancer growth. We examined the association between METTL14 expression, cancer progression, and patient prognosis in a total of 398 breast cancer tissue specimens. Significantly fewer cancer tissue specimens compared with norma...

journal_title：BioMed research international

authors： Dong XF,Wang Y,Huang BF,Hu GN,Shao JK,Wang Q,Tang CH,Wang CQ

更新日期：2020-10-20 00:00:00

abstract：:Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out...

journal_title：BioMed research international

authors： Hu WP,Kumar JV,Huang CJ,Chen WY

更新日期：2015-01-01 00:00:00

abstract：:This research assessed the seasonal variation of the chemical composition and antibacterial and anticholinesterase activities of essential oils extracted from M. longifolia leaves. The leaves organic fractions were also investigated for their biological activities and pharmacological functions. The essential oil highe...

journal_title：BioMed research international

authors： Zouari-Bouassida K,Trigui M,Makni S,Jlaiel L,Tounsi S

更新日期：2018-12-09 00:00:00

abstract：:Mortierella sp. has been known to produce polyunsaturated fatty acids (PUFAs) such as GLA and AA under normal growth medium conditions. Similarly, under the stress condition, this fungus produces EPA and DHA in their mycelial biomass. Among the 67 soil samples screened from the Western Ghats of India, 11 Mortierella i...

journal_title：BioMed research international

authors： Vadivelan G,Venkateswaran G

更新日期：2014-01-01 00:00:00

abstract：:Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...

journal_title：BioMed research international

authors： Zhu M,Yang M,Yang Q,Liu W,Geng H,Pan L,Wang L,Ge R,Ji L,Cui S,Li Z

更新日期：2020-01-23 00:00:00

abstract：:Herein the extraction method of fucoidan from Laminaria japonica is reported. Firstly, chitosan, chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (HACC), and hexadecyltrimethylammonium bromide (CPAB) were used to extract the fucoidan. The results showed that chitosan was the optimal extractant compared with the ...

journal_title：BioMed research international

authors： Xing R,Liu S,Yu H,Chen X,Qin Y,Li K,Li P

更新日期：2013-01-01 00:00:00

abstract：Background:Shedding of the endothelial glycocalyx layer (EGL) is known to occur during major surgery, but its degradation associated with minimally invasive video-assisted thoracoscopy (VATS) remains unclear. We investigated if serum biomarkers of EGL disruption were elevated during VATS lobectomy, and whether the urin...

journal_title：BioMed research international

authors： Wang J,Wu A,Wu Y

更新日期：2017-01-01 00:00:00

abstract：:Therapeutic approach for Alzheimer's disease (AD) is still deficient. To find active compounds from herbal medicine is of interest in the alleviation of AD symptoms. This study aimed to investigate the protective effects of Tanshinone IIA (TIIA) on memory performance and synaptic plasticity in a transgenic AD model at...

journal_title：BioMed research international

authors： Li F,Han G,Wu K

更新日期：2016-01-01 00:00:00

abstract：:The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and ...

journal_title：BioMed research international

authors： Shinoda K,Hayashi S,Fukuoka D,Torii R,Watanabe T,Nakano T

更新日期：2016-01-01 00:00:00

abstract：:Introduction. Infection and apoptosis are combined triggers for inflammation in dental tissues. Octamer-binding transcription factor 4-B1 (OCT4B1), a novel spliced variant of OCT4 family, could respond to the cellular stress and possess antiapoptotic property. However, its specific role in dental pulpitis remains unkn...

journal_title：BioMed research international

authors： Liu L,Huang R,Yang R,Wei X

更新日期：2017-01-01 00:00:00

abstract：:Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...

journal_title：BioMed research international

authors： Obuchowicz R,Piórkowski A,Urbanik A,Strzelecki M

更新日期：2019-11-20 00:00:00

abstract：Purpose:3D nonfluoroscopic mapping systems (NMSs) are generally used in the catheter ablation (CA) of complex ventricular and atrial arrhythmias. The aim of this study was to evaluate the efficacy, safety, and long-term effect of the extended, routine use of NMSs for CA. Methods:Our study involved 1028 patients who un...

journal_title：BioMed research international

authors： Marini M,Martin M,Ravanelli D,Del Greco M,Quintarelli S,Guarracini F,Coser A,Valentini A,Bonmassari R

更新日期：2019-03-10 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) K88 is a zoonotic pathogen. Previous studies have shown that lactic acid bacteria (LAB) have great potential in promoting health and resisting pathogenic infections; however, relatively little research has been done on the Pediococcus genus of LAB. This study is aimed at explori...

journal_title：BioMed research international

authors： Tan K,Deng D,Ma X,Cui Y,Tian Z

更新日期：2020-03-30 00:00:00

abstract：:Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk...

journal_title：BioMed research international

authors： Gibson-Corley KN,Flouty O,Oya H,Gillies GT,Howard MA

更新日期：2014-01-01 00:00:00

abstract：Background:Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be relate...

journal_title：BioMed research international

authors： Liu J,Wang G,Peng Z

更新日期：2020-05-20 00:00:00

abstract：:The valorization of Crocus sativus L. by-products has become important given its interesting content of bioactive molecules. In the present study, aqueous tepal extract (ATE) studied eggplant seedling's growth and physiology under a plastic tunnel. ATE was foliage sprayed 3 times every 15 days, with various concentrat...

journal_title：BioMed research international

authors： Khoulati A,Ouahhoud S,Mamri S,Meziane M,Choukri M,Asehraou A,Saalaoui E

更新日期：2020-11-05 00:00:00

abstract：:Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulation of the amyloid-β peptide 1-42 (Aβ42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas of the brain and, more recently reported, in the visual cortex. Recently, Aβ42 peptid...

journal_title：BioMed research international

authors： Hernández-Zimbrón LF,Perez-Hernández M,Torres-Romero A,Gorostieta-Salas E,Gonzalez-Salinas R,Gulias-Cañizo R,Quiroz-Mercado H,Zenteno E

更新日期：2017-01-01 00:00:00

abstract：:Trichoderma spp. are important biocontrol filamentous fungi, which are widely used for their adaptability, broad antimicrobial spectrum, and various antagonistic mechanisms. In our previous studies, we cloned thga1 gene encoding GαI protein from Trichoderma harzianum Th-33. Its knockout mutant showed that the growth r...

journal_title：BioMed research international

authors： Sun Q,Jiang X,Pang L,Wang L,Li M

更新日期：2016-01-01 00:00:00

abstract：:Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temephos (OP), deltamethr...

journal_title：BioMed research international

authors： Bellinato DF,Viana-Medeiros PF,Araújo SC,Martins AJ,Lima JB,Valle D

更新日期：2016-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system (CNS). Neurotropic demyelinating strain of MHV (MHV-A59 or its isogenic recombinant strain RSA59) induces MS-like disease in mice mediated by microglia, along with a small population of T cells. The mechanism of demyel...

journal_title：BioMed research international

authors： Kishore A,Kanaujia A,Nag S,Rostami AM,Kenyon LC,Shindler KS,Das Sarma J

更新日期：2013-01-01 00:00:00

abstract：:The main objective was to quantify the effects of five different slopes on trunk and shoulder kinematics as well as shoulder kinetic and muscular demands during manual wheelchair (MWC) propulsion on a motorized treadmill. Eighteen participants with spinal cord injury propelled their MWC at a self-selected constant spe...

journal_title：BioMed research international

authors： Gagnon D,Babineau AC,Champagne A,Desroches G,Aissaoui R

更新日期：2015-01-01 00:00:00

abstract：:A reliable in vivo imaging method to localize transplanted cells and monitor their viability would enable a systematic investigation of cell therapy. Most stem cell transplantation studies have used immunohistological staining, which does not provide information about the migration of transplanted cells in vivo in the...

journal_title：BioMed research international

authors： Kim JH,Lee HJ,Song YS

更新日期：2015-01-01 00:00:00

abstract：:Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...

journal_title：BioMed research international

authors： Zhang YH,Chen AL,Yu RQ,Jia BB,Ye DN,Wang M,Mei YZ,Fang GD,Jiang SY,Zhou Q,Zhang B

更新日期：2021-01-05 00:00:00

abstract：:This work evaluated the physicochemical properties and antioxidant activity of spray dried extracts (SDE) from Psidium guajava L. leaves. Different drying carriers, namely, maltodextrin, colloidal silicon dioxide, Arabic gum, and β -cyclodextrin at concentrations of 40 and 80% relative to solids content, were added to...

journal_title：BioMed research international

authors： Fernandes MR,Azzolini AE,Martinez ML,Souza CR,Lucisano-Valim YM,Oliveira WP

更新日期：2014-01-01 00:00:00