Different mechanisms of inflammation induced in virus and autoimmune-mediated models of multiple sclerosis in C57BL6 mice.

abstract：:Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...

journal_title：BioMed research international

authors： Zhu M,Yang M,Yang Q,Liu W,Geng H,Pan L,Wang L,Ge R,Ji L,Cui S,Li Z

更新日期：2020-01-23 00:00:00

abstract：:Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Mu...

journal_title：BioMed research international

authors： Gehmert S,Wenzel C,Loibl M,Brockhoff G,Huber M,Krutsch W,Nerlich M,Gosau M,Klein S,Schreml S,Prantl L,Gehmert S

更新日期：2014-01-01 00:00:00

abstract：:Toxoplasma gondii with worldwide distribution has received substantial medical and scientific attentions as it causes serious clinical and veterinary problems especially for pregnant women and immunocompromised patients. Heat shock protein 40 (HSP40) plays a variety of essential roles in the pathogenesis of this proto...

journal_title：BioMed research international

authors： Li ZY,Lu J,Zhou DH,Chen J,Zhu XQ

更新日期：2015-01-01 00:00:00

abstract：:Purpose. We aimed to study long-term outcome after pulmonary vein isolation (PVI) guided by remote magnetic navigation (RMN) and provided comparative data to outcome after manual navigation (MAN). Methods. Three hundred thirty-six patients with symptomatic paroxysmal AF underwent PVI by irrigated point-by-point radiof...

journal_title：BioMed research international

authors： Kataria V,Berte B,Vandekerckhove Y,Tavernier R,Duytschaever M

更新日期：2017-01-01 00:00:00

abstract：:T. reesei is an efficient cellulase producer and biomass degrader. To improve xylitol production in Trichoderma reesei strains by genetic engineering, two approaches were used in this study. First, the presumptive D-xylulokinase gene in T. reesei (xyiH), which has high homology to known fungi D-xylulokinase genes, was...

journal_title：BioMed research international

authors： Hong Y,Dashtban M,Kepka G,Chen S,Qin W

更新日期：2014-01-01 00:00:00

abstract：:L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases ex...

journal_title：BioMed research international

authors： Izidoro LF,Sobrinho JC,Mendes MM,Costa TR,Grabner AN,Rodrigues VM,da Silva SL,Zanchi FB,Zuliani JP,Fernandes CF,Calderon LA,Stábeli RG,Soares AM

更新日期：2014-01-01 00:00:00

abstract：:Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreat...

journal_title：BioMed research international

authors： Guo R,Gu J,Zhang Z,Wang Y,Gu C

更新日期：2017-01-01 00:00:00

abstract：:Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to ...

journal_title：BioMed research international

authors： Rocha TL,Dias-Junior CA,Possomato-Vieira JS,Gonçalves-Rizzi VH,Nogueira FR,de Souza KM,Braz LG,Braz MG

更新日期：2015-01-01 00:00:00

abstract：AIM:To create a predictive score for the discrimination between benign and malignant parotid tumors using elastographic parameters and to compare its sensitivity and specificity with standard ultrasound. METHODS:A total of 124 patients with parotid gland lesions for whom surgery was planned were examined using convent...

journal_title：BioMed research international

authors： Heřman J,Sedláčková Z,Vachutka J,Fürst T,Salzman R,Vomáčka J,Heřman M

更新日期：2017-01-01 00:00:00

abstract：:Cholesteatoma is an epidermoid cyst, which is most frequently found in the middle ear. The matrix of cholesteatoma is histologically similar to the matrix of the epidermoid cyst of the skin (atheroma); their epithelium is characterized by hyperproliferation. The c-MYC protooncogene located on chromosome 8q24 encodes a...

journal_title：BioMed research international

authors： Palkó E,Póliska S,Csákányi Z,Katona G,Karosi T,Helfferich F,Penyige A,Sziklai I

更新日期：2014-01-01 00:00:00

abstract：:Natural medical plant is considered as a good source of tyrosinase inhibitors. Red vine leaf extract (RVLE) can be applied to a wide variety of medical disciplines, such as treatments for chronic venous insufficiency over many decades. This study investigated the tyrosinase inhibitory activity of RVLE containing galli...

journal_title：BioMed research international

authors： Lin YS,Chen HJ,Huang JP,Lee PC,Tsai CR,Hsu TF,Huang WY

更新日期：2017-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are composed of a group of endogenous and noncoding small RNAs which control expression of complementary target mRNAs. The extended functions of miRNAs enhance the complexity of gene-regulatory processes in cardiovascular and cerebrovascular diseases. Indeed, recent studies have shown that miRNAs ar...

journal_title：BioMed research international

authors： Li M,Zhang J

更新日期：2015-01-01 00:00:00

abstract：:Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-bindin...

journal_title：BioMed research international

authors： Righetto I,Filippini F

更新日期：2018-05-17 00:00:00

abstract：:Understanding the mechanism behind the structure of the internal cellular clock can lead to advances in the knowledge of origins of pairs of monozygotic twins and higher order multiples as well as other biological phenomena. To gain insight into this mechanism, we analyze possible cell labeling schemes that model an o...

journal_title：BioMed research international

authors： Jim C,Berkovich S

更新日期：2015-01-01 00:00:00

abstract：:The regiospecific distribution of fatty acids (FAs) and composition of triglyceride (TAG) molecular species of fishes were analyzed and calculated by pancreatic lipase (PL) hydrolysis and Visual Basic (VB) program. DHA was preferentially located at sn-2 position in TAG molecule, whereas EPA was almost equally distribu...

journal_title：BioMed research international

authors： Zhang H,Shen Y,Zhang Y,Li L,Wang X

更新日期：2018-01-29 00:00:00

abstract：:In patients with sepsis and septic shock, the hemodynamic management in both early and later phases of these "organ dysfunction syndromes" is a key therapeutic component. It needs, however, to be differentiated between "early goal-directed therapy" (EGDT) as proposed for the first 6 hours of emergency department treat...

journal_title：BioMed research international

authors： Saugel B,Huber W,Nierhaus A,Kluge S,Reuter DA,Wagner JY

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Tumor patients and patients after traumas are endangered by a reduced immune defense, and a silver coating on their megaprostheses may reduce their risks of infection. The aim of this study was to determine the silver ion concentration directly measured from the periprosthetic tissue and the influence on the...

journal_title：BioMed research international

authors： Hussmann B,Johann I,Kauther MD,Landgraeber S,Jäger M,Lendemans S

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/8094152.]. ...

journal_title：BioMed research international

authors： Xie Y,Su Y,Min S,Tang J,Goh BT,Saigo L,Ansari S,Moshaverinia A,Zhang C,Wang J,Liu Y,Khojasteh A,Zadeh HH,Wang S

更新日期：2017-01-01 00:00:00

abstract：Objective:To retrospectively investigate computed tomographic (CT) quantitative analysis of ground-glass opacity (GGO) volume percentage and morphologic features of resected lung adenocarcinomas according to epidermal growth factor receptor (EGFR) mutation status and subtypes. Methods:Amplification refractory mutation...

journal_title：BioMed research international

authors： Wang H,Guo H,Wang Z,Shan B,Lin J

更新日期：2019-03-06 00:00:00

abstract：Objective:To explore multiscale integrated analysis methods in identifying key regulators of esophageal cancer (ESCA). Methods:We downloaded the ESCA dataset from The Cancer Genome Atlas (TCGA) database, which contained RNA-seq data, miRNA-seq data, methylation data, and clinical phenotype information. Then, we combin...

journal_title：BioMed research international

authors： Xu Z,Wu Z,Zhang J,Zhou R,Wu J,Yu B

更新日期：2020-08-12 00:00:00

abstract：:High-dose melphalan (200 mg/m(2)) as conditioning regimen followed by autologous stem cell transplantation (ASCT) rescue has been established as a standard treatment for patients with multiple myeloma (MM) younger than 65 years of age. However, the role of ASCT in elderly patients older than 65 years remains controver...

journal_title：BioMed research international

authors： Ozaki S,Shimizu K

更新日期：2014-01-01 00:00:00

abstract：:Catalases are widely used in many scientific areas. A catalase gene (Kat) from Geobacillus sp. CHB1 encoding a monofunctional catalase was cloned and recombinant expressed in Escherichia coli (E. coli), which was the first time to clone and express this type of catalase of genus Geobacillus strains as far as we know. ...

journal_title：BioMed research international

authors： Jia X,Chen J,Lin C,Lin X

更新日期：2016-01-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) K88 is a zoonotic pathogen. Previous studies have shown that lactic acid bacteria (LAB) have great potential in promoting health and resisting pathogenic infections; however, relatively little research has been done on the Pediococcus genus of LAB. This study is aimed at explori...

journal_title：BioMed research international

authors： Tan K,Deng D,Ma X,Cui Y,Tian Z

更新日期：2020-03-30 00:00:00

abstract：:Purpose. This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients. Methods. We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to ...

journal_title：BioMed research international

authors： Lou S,Lv H,Wang G,Zhang L,Li M,Li Z,Zhang L,Tang P

更新日期：2016-01-01 00:00:00

abstract：:Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged o...

journal_title：BioMed research international

authors： Song Y,Zhao Y,Wang F,Tao L,Xiao J,Yang C

更新日期：2014-01-01 00:00:00

abstract：:It has been reported that many modifications occur with the increase of oxidative stress during storage in erythrocytes. In order to delay these negative changes, we evaluated whether the addition of substances likely to protect antioxidant capacity in stored blood would be useful. Therefore, we investigated the effec...

journal_title：BioMed research international

authors： Huyut Z,Şekeroğlu MR,Balahoroğlu R,Karakoyun T,Çokluk E

更新日期：2016-01-01 00:00:00

abstract：:The search for effective methods of myocardial cytoprotection against ischemia is the most significant issue in modern cardiology and cardiac surgery. Glucocorticoids are deemed very strong modulators of inflammatory response and thus can potentially protect heart muscle from postreperfusion injury and myocardial isch...

journal_title：BioMed research international

authors： Kuropka P,Dobrzyński M,Gamian A,Gostomska-Pampuch K,Kuryszko J,Całkosiński I

更新日期：2017-01-01 00:00:00

abstract：Background:Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods:Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosi...

journal_title：BioMed research international

authors： Deng M,Wang J,Wu H,Wang M,Cao D,Li J,Wu Y,Gong J

更新日期：2020-03-18 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States Food and Drug Admini...

journal_title：BioMed research international

authors： Murata S,Zhang C,Finch N,Zhang K,Campo L,Breuer EK

更新日期：2016-01-01 00:00:00

abstract：:DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinde...

journal_title：BioMed research international

authors： Zaman R,Chowdhury SY,Rashid MA,Sharma A,Dehzangi A,Shatabda S

更新日期：2017-01-01 00:00:00