Snake venom L-amino acid oxidases: trends in pharmacology and biochemistry.

Abstract:

:L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity. These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents. This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.

journal_name

Biomed Res Int

authors

Izidoro LF,Sobrinho JC,Mendes MM,Costa TR,Grabner AN,Rodrigues VM,da Silva SL,Zanchi FB,Zuliani JP,Fernandes CF,Calderon LA,Stábeli RG,Soares AM

doi

10.1155/2014/196754

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

196754

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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