Abstract:
:Heart disease is the leading cause of death worldwide. Therefore, assessing the risk of its occurrence is a crucial step in predicting serious cardiac events. Identifying heart disease risk factors and tracking their progression is a preliminary step in heart disease risk assessment. A large number of studies have reported the use of risk factor data collected prospectively. Electronic health record systems are a great resource of the required risk factor data. Unfortunately, most of the valuable information on risk factor data is buried in the form of unstructured clinical notes in electronic health records. In this study, we present an information extraction system to extract related information on heart disease risk factors from unstructured clinical notes using a hybrid approach. The hybrid approach employs both machine learning and rule-based clinical text mining techniques. The developed system achieved an overall microaveraged F-score of 0.8302.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Jonnagaddala J,Liaw ST,Ray P,Kumar M,Dai HJ,Hsu CYdoi
10.1155/2015/636371subject
Has Abstractpub_date
2015-01-01 00:00:00pages
636371eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract:Background:Ischemic heart disease (IHD) is the major cause of death in patients with cardiovascular disease. Cardiac remodeling is a common pathological change following myocardial infarction (MI), and cardiomyocyte apoptosis plays a key role in this change. Transcription factor recombination signal-binding protein-J (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5207031
更新日期:2018-07-03 00:00:00
abstract::Objective. This study aims to extract motor ingredients through data mining from wearable sensors in a virtual reality goal-directed shoulder rehabilitation (GDSR) system and to examine their effects toward clinical assessment. Design. A single-group before/after comparison. Setting. Outpatient research hospital. Subj...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7075464
更新日期:2016-01-01 00:00:00
abstract:AIM:To evaluate the impact of SPARC on female sexual function. METHODS:151 women with a mean age of 60 ± 11.90 and SUI had a complete urodynamic investigation and underwent SPARC operation. 98 women completed the validated female sexual function index questionnaire (FSFI) at baseline and 94 women at follow-up. A minim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/957547
更新日期:2013-01-01 00:00:00
abstract::The aim of this study is to investigate the stress distributions of different restoration options for class II mesio-occluso-distal (MOD) cavities. A class II MOD cavity with proximal box gingival floor 1 mm below cementoenamel junction was designed in a mandibular first molar tooth model. 3D finite-element analysis (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7435054
更新日期:2020-12-15 00:00:00
abstract::Numerous studies have reported that mesenchymal stem cells (MSCs) can ameliorate neurological deficits in ischemic stroke models. Among the various hypotheses that have been suggested to explain the therapeutic mechanism underlying these observations, neurogenesis is thought to be critical. To enhance the therapeutic ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/129145
更新日期:2014-01-01 00:00:00
abstract::Schwannomas are the commonest tumours of peripheral nerves. Despite the classical description that schwannomas are well encapsulated and can be completely enucleated during excision, a portion of them have fascicular involvement and could not be completely shelled out. A retrospective review for 8 patients was carried...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/167196
更新日期:2013-01-01 00:00:00
abstract:Objectives:The mortality rate of patients with acute respiratory distress syndrome (ARDS) is high. Hence, it is crucial to identify a reliable biomarker with wide clinical applications for predicting the prognosis of patients with ARDS. This systematic review and meta-analysis was conducted to investigate the value of ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2020/3472615
更新日期:2020-04-05 00:00:00
abstract::There has been a remarkable interest in finding lipid inhibitors from natural products to replace synthetic compounds, and a variety of oriental medicinal herbs are reported to have biological activity with regard to lipid inhibition. Buginawa (Bugi) is a novel combined formula that contains twelve medicinal herbs wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3101987
更新日期:2019-07-30 00:00:00
abstract::Post-Kala-Azar Dermal Leishmaniasis (PKDL) remains a major public health threat in Bangladesh. A cross-sectional study was carried out in Surya Kanta Kala azar Research Centre (SKKRC), Mymensingh, from January 2012 to July 2013 to evaluate the health seeking behaviour and the length of delay of PKDL management. The co...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/314543
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to analyse the circadian behavioural responses of mice carrying a functional knockout of the Per3 gene (Per3(-/-)) to different light : dark (L : D) cycles. Male adult wild-type (WT) and Per3(-/-) mice were kept under 12-hour light : 12-hour dark conditions (12L : 12D) and then transferred to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/170795
更新日期:2014-01-01 00:00:00
abstract::Impact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood. In this study, a rat model of smoking-related lung injury was induced and the rats were treated with vehicle or BMSCs for two weeks. Different subsets of CD4+ T cells, cytokines, and anti-elastin ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/932923
更新日期:2015-01-01 00:00:00
abstract::Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction protocol could be ef...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7328469
更新日期:2020-02-18 00:00:00
abstract::Liver cell culture within three-dimensional structures provides an improved culture system for various applications in basic research, pharmacological screening, and implantable or extracorporeal liver support. Biodegradable calcium-based scaffolds in such systems could enhance liver cell functionality by providing en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6040146
更新日期:2016-01-01 00:00:00
abstract::Microbial strain optimisation for the overproduction of a desired phenotype has been a popular topic in recent years. Gene knockout is a genetic engineering technique that can modify the metabolism of microbial cells to obtain desirable phenotypes. Optimisation algorithms have been developed to identify the effects of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/124537
更新日期:2015-01-01 00:00:00
abstract::Several studies have compared molecular components between red and white skeletal muscles in mammals. However, mammalian skeletal muscles are composed of mixed types of muscle fibers. In the current study, we analyzed and compared the distributions of titin, lipid, phosphate ions, and fatty acid levels in red and whit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5816875
更新日期:2018-11-18 00:00:00
abstract::Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan. The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population. Here, 12732 participants were selected from the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2947067
更新日期:2020-12-11 00:00:00
abstract::T. reesei is an efficient cellulase producer and biomass degrader. To improve xylitol production in Trichoderma reesei strains by genetic engineering, two approaches were used in this study. First, the presumptive D-xylulokinase gene in T. reesei (xyiH), which has high homology to known fungi D-xylulokinase genes, was...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/169705
更新日期:2014-01-01 00:00:00
abstract::Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long no...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/2405351
更新日期:2018-05-22 00:00:00
abstract::It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a tar...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/736104
更新日期:2015-01-01 00:00:00
abstract::Although extensive studies have identified large number of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in ischemic stroke, the RNA regulation network response to focal ischemia remains poorly understood. In this study, we simultaneously interrogate the expression profiles of lncRNAs, miRNAs, and mRNAs changes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8354350
更新日期:2018-01-08 00:00:00
abstract::Lung injury was the common and serious complication of sepsis, a systemic inflammatory response syndrome caused by severe infections. Chinese medicine had unique advantages in attenuating inflammatory response, such as Zuojinfang (ZJF). ZJF was a classical compound herb formula composed of Coptidis Rhizoma and Euodiae...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/1419631
更新日期:2021-01-06 00:00:00
abstract::Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/143109
更新日期:2015-01-01 00:00:00
abstract::The aim of the study was to comparatively evaluate the fracture strength and mode of root canal treated teeth restored with resin composites with and without posts. The lingual cusps of root canal treated first upper premolars (n = 10/group) were removed down to cervical enamel and restored with the following: group A...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9054301
更新日期:2018-08-14 00:00:00
abstract::Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route ...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版,评审
doi:10.1155/2014/934605
更新日期:2014-01-01 00:00:00
abstract::Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and exist as an important cause of pulmonary infections in humans. Pulmonary involvement is the most common disease manifestation of NTM and the incidence of NTM is growing in North America. Susceptibility to NTM infection is incompletely understood; ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/919474
更新日期:2014-01-01 00:00:00
abstract::The complete chloroplast genome of J. flava, an endangered medicinal plant in Saudi Arabia, was sequenced and compared with cp genome of three Acanthaceae species to characterize the cp genome, identify SSRs, and also detect variation among the cp genomes of the sampled Acanthaceae. NOVOPlasty was used to assemble the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4370258
更新日期:2019-08-06 00:00:00
abstract::Iran is one of the six countries with the most cutaneous leishmaniasis (CL) patients. Understanding better the genotypes of the parasite population in relation to geography and climate is critical to achieving better CL control. We aimed to characterise the population structure of Leishmania tropica, the cause of anth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6049198
更新日期:2018-06-06 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/3746232.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/1235429
更新日期:2016-01-01 00:00:00
abstract:Objective:To investigate whether preventive administration of a proton pump inhibitor (PPI) can reduce the occurrence and development of traumatic granuloma (TG) following type IV-VI cordectomy. Methods:We retrospectively analyzed the status of postoperative granulomas in 37 patients who underwent type IV-VI cordectom...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4178376
更新日期:2020-08-10 00:00:00
abstract::Purslane, a fleshy herbaceous plant, plays a pivotal role in various preventive and therapeutic purposes. To date, no report has documented the consequence of salt stress on metabolite accumulation in purslane. Herein, we proposed an insight into the metabolic and physiological traits of purslane under saline stress e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4827045
更新日期:2020-06-17 00:00:00