Blockade of RBP-J-Mediated Notch Signaling Pathway Exacerbates Cardiac Remodeling after Infarction by Increasing Apoptosis in Mice.

abstract：:Cancer metastasis has been demonstrated as it is the culmination of a cascade of priming steps. Increasing evidence has shown that tumor-derived molecular components (TDMCs) are known as extra cellular vesicle and nonvesicle factors and serve as versatile intercellular communication vehicles which can mediate signalin...

journal_title：BioMed research international

authors： Zhang Z,Qiao J,Zhang D,Zhu W,Zhu J,Leng X,Li S

更新日期：2019-06-12 00:00:00

abstract：:Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...

journal_title：BioMed research international

authors： Amaya-Amaya J,Montoya-Sánchez L,Rojas-Villarraga A

更新日期：2014-01-01 00:00:00

abstract：:Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance. This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tubercul...

journal_title：BioMed research international

authors： Belay M,Ameni G,Bjune G,Couvin D,Rastogi N,Abebe F

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:The safety and efficacy of endoscopic sphincterotomy with large balloon dilation (EPLBD) are unclear. This study compares the safety and efficacy between EPLBD and endoscopic sphincterotomy (EST). PATIENTS AND METHODS:Literatures were searched for randomized controlled trials in PUBMED, EMBASE, and Cochrane...

journal_title：BioMed research international

authors： Xu L,Kyaw MH,Tse YK,Lau JY

更新日期：2015-01-01 00:00:00

abstract：:We identified a nitidine- (NTD-) accumulating organelle and evaluated the net cytotoxicity of accumulated NTD. To evaluate tumor cell selectivity of the drug, we evaluated its selective cytotoxicity against 39 human cancer cell lines (JFCR39 panel), and the profile was compared with those of known anticancer drugs. Or...

journal_title：BioMed research international

authors： Iwasaki H,Inafuku M,Taira N,Saito S,Oku H

更新日期：2017-01-01 00:00:00

abstract：:Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-β (TGF-β). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts...

journal_title：BioMed research international

authors： Rodrigues-Diez R,Rodrigues-Diez RR,Lavoz C,Carvajal G,Droguett A,Garcia-Redondo AB,Rodriguez I,Ortiz A,Egido J,Mezzano S,Ruiz-Ortega M

更新日期：2014-01-01 00:00:00

abstract：Background:In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood. Methods and Results:This pilot study (n=48) compared plasma levels of corin, neprilysin, ...

journal_title：BioMed research international

authors： Zaidi SS,Ward RD,Ramanathan K,Yu X,Gladysheva IP,Reed GL

更新日期：2018-07-26 00:00:00

abstract：BACKGROUND:This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. METHODS:Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneou...

journal_title：BioMed research international

authors： Akashi M,Hashikawa K,Wanifuchi S,Kusumoto J,Shigeoka M,Furudoi S,Terashi H,Komori T

更新日期：2017-01-01 00:00:00

abstract：:Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...

journal_title：BioMed research international

authors： Wu S,Yu S,Zhuang L,Wei X,Sak M,Duric N,Hu J,Xie Y

更新日期：2017-01-01 00:00:00

abstract：:Macrophages, especially their activation state, are closely related to the progression of diabetic nephropathy. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. 1,25-Dihydroxyvitamin D3 has renoprotective roles th...

journal_title：BioMed research international

authors： Zhang X,Zhou M,Guo Y,Song Z,Liu B

更新日期：2015-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a global health concern, and the recent literature reports that a single mild TBI can result in chronic traumatic encephalopathy (CTE). It has been suggested that CTE may lead to death by suicide, raising important prevention, treatment, and policy implications. Thus, we conducted a sys...

journal_title：BioMed research international

authors： Wortzel HS,Shura RD,Brenner LA

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy. METHODS:In this cross-sectional study UC patients were interviewed, ...

journal_title：BioMed research international

authors： da Silva BC,Lyra AC,Mendes CM,Ribeiro CP,Lisboa SR,de Souza MT,Portela RC,Santana GO

更新日期：2015-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2012/853879.]. ...

journal_title：BioMed research international

authors： Shirasu N,Yamada H,Shibaguchi H,Kuroki M,Kuroki M

更新日期：2015-01-01 00:00:00

abstract：:Majority of gram negative pathogenic bacteria are responsible for extended spectrum β-lactamases (ESBLs) production, which show resistance to some newer generation of antibiotics. The study was aimed at evaluating the prevalence of ESBL and antibiotic susceptibility pattern of Pseudomonas isolates collected during 201...

journal_title：BioMed research international

authors： Ahmad M,Hassan M,Khalid A,Tariq I,Asad MH,Samad A,Mahmood Q,Murtaza G

更新日期：2016-01-01 00:00:00

abstract：:Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can b...

journal_title：BioMed research international

authors： Kang J,Fan W,Deng Q,He H,Huang F

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:This study aimed to compare the effects of rectal midazolam addition after applying bupivacaine and caudal anesthesia on postoperative analgesia time, the need for additional analgesics, postoperative recovery, and sedation and to find out its adverse effects in children having lower abdominal surgery. METH...

journal_title：BioMed research international

authors： Saylan S,Eroglu A,Dohman D

更新日期：2014-01-01 00:00:00

abstract：:Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...

journal_title：BioMed research international

authors： Pyshnaya IA,Razum KV,Poletaeva JE,Pyshnyi DV,Zenkova MA,Ryabchikova EI

更新日期：2014-01-01 00:00:00

abstract：:The aim of this population-based cohort study was to explore postoperative renal outcomes of patients receiving pyelolithotomy versus percutaneous nephrolithotomy (PCNL). Data were retrieved from the Taiwan National Health Insurance Research Database. During the period from Jan 1, 1998, to Dec 31, 2012, there were 254...

journal_title：BioMed research international

authors： Chen FT,Liu FC,Cheng CW,Lin JR,Yu HP

更新日期：2018-05-02 00:00:00

abstract：:The objective and quantitative analysis of longitudinal single photon emission computed tomography (SPECT) images are significant for the treatment monitoring of brain disorders. Therefore, a computer aided analysis (CAA) method is introduced to extract a change-rate map (CRM) as a parametric image for quantifying the...

journal_title：BioMed research international

authors： Zheng X,Wei W,Huang Q,Song S,Wan J,Huang G

更新日期：2017-01-01 00:00:00

abstract：:Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epi...

journal_title：BioMed research international

authors： Caggiano G,Coretti C,Bartolomeo N,Lovero G,De Giglio O,Montagna MT

更新日期：2015-01-01 00:00:00

abstract：:This study is to investigate multiple chemotherapeutic agent- and radiation-related genetic biomarkers in locally advanced rectal cancer (LARC) patients following fluoropyrimidine-based concurrent chemoradiotherapy (CCRT) for response prediction. We initially selected 6 fluoropyrimidine metabolism-related genes (DPYD,...

journal_title：BioMed research international

authors： Huang MY,Wu CH,Huang CM,Chung FY,Huang CW,Tsai HL,Chen CF,Lin SR,Wang JY

更新日期：2013-01-01 00:00:00

abstract：:Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...

journal_title：BioMed research international

authors： Atalar E,Eskin F,Tugtekin HB,Karabulut A,Kanyilmaz S,Kirbiyik H,Ozyildiz AG

更新日期：2020-09-05 00:00:00

abstract：:Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...

journal_title：BioMed research international

authors： Miao YY,Liu J,Zhu J,Tao YL,Zhang JA,Luo D,Zhou BR

更新日期：2017-01-01 00:00:00

abstract：:Primary cilia are organelles protruding from cell surface into environment that function in regulating cell cycle and modulating cilia-related signal. Primary ciliogenesis and autophagy play important roles in tumorigenesis. However, the functions and interactions between primary cilia and autophagy in hepatocellular ...

journal_title：BioMed research international

authors： Liu L,Sheng JQ,Wang MR,Gan Y,Wu XL,Liao JZ,Tian DA,He XX,Li PY

更新日期：2019-10-02 00:00:00

abstract：:ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria. However, no evidence show that circulating ELA is deficient in early placental develo...

journal_title：BioMed research international

authors： Ma S,Guo C,Zhang J,Long S,Tan H,You Y

更新日期：2020-09-28 00:00:00

abstract：OBJECTIVE:Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare...

journal_title：BioMed research international

authors： Chen CH,Tai SB,Chen HC,Yang DH,Peng MY,Lin YF

更新日期：2015-01-01 00:00:00

abstract：:Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement....

journal_title：BioMed research international

authors： Nisticò S,Campolmi P,Moretti S,Del Duca E,Bruscino N,Conti R,Bassi A,Cannarozzo G

更新日期：2016-01-01 00:00:00

abstract：:A series of sulfonamide-bearing azaheterocyclic Schiff base derivatives 3(a-j) were synthesized as carbonic anhydrase inhibitors. The substituted benzene sulfonyl chlorides 1(a-d) were reacted with N2H4 to get aromatic sulfonyl hydrazides 2(a-d). The intermediate hydrazides 2(a-d) were treated with substituted aldehyd...

journal_title：BioMed research international

authors： Abas M,Rafique H,Shamas S,Roshan S,Ashraf Z,Iqbal Z,Raza H,Hassan M,Afzal K,Rizvanov AA,Asad MHHB

更新日期：2020-02-20 00:00:00

abstract：:WalkinSense is a new device designed to monitor walking. The aim of this study was to measure the accuracy and repeatability of the gait analysis performed by the WalkinSense system. Descriptions of values recorded by WalkinSense depicting typical gait in adults are also presented. A bench experiment using the Trublu ...

journal_title：BioMed research international

authors： de Castro MP,Meucci M,Soares DP,Fonseca P,Borgonovo-Santos M,Sousa F,Machado L,Vilas-Boas JP

更新日期：2014-01-01 00:00:00

abstract：Background:DNA methylation is essential for regulating gene expression, and the changes of DNA methylation status are commonly discovered in disease. Therefore, identification of differentially methylation patterns, especially differentially methylated regions (DMRs), in two different groups is important for understand...

journal_title：BioMed research international

authors： Zhang Y,Wang S,Wang X

更新日期：2018-11-18 00:00:00