Peripheral leukocyte apoptosis in patients with Parkinsonism: correlation with clinical characteristics and neuroimaging findings.

Abstract:

:Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and prevention of PD. The present study demonstrated that leukocyte apoptosis is significantly higher in PD patients and is associated with central dopamine neuron loss by using (99m)Tc-TRODAT-1 SPECT. The leukocyte apoptosis and striatal dopamine transporter uptake ratios were further associated with increased severity and longer duration of disease. The interaction between brain and systemic inflammation may be responsible for the neurodegenerative disease progression.

journal_name

Biomed Res Int

authors

Lin WC,Tsai NW,Huang YC,Cheng KY,Chen HL,Li SH,Kung CT,Su YJ,Lin WM,Chen MH,Chiu TM,Yang IH,Lu CH

doi

10.1155/2014/635923

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

635923

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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