Abstract:
:Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and prevention of PD. The present study demonstrated that leukocyte apoptosis is significantly higher in PD patients and is associated with central dopamine neuron loss by using (99m)Tc-TRODAT-1 SPECT. The leukocyte apoptosis and striatal dopamine transporter uptake ratios were further associated with increased severity and longer duration of disease. The interaction between brain and systemic inflammation may be responsible for the neurodegenerative disease progression.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Lin WC,Tsai NW,Huang YC,Cheng KY,Chen HL,Li SH,Kung CT,Su YJ,Lin WM,Chen MH,Chiu TM,Yang IH,Lu CHdoi
10.1155/2014/635923subject
Has Abstractpub_date
2014-01-01 00:00:00pages
635923eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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