Ultrasound-mediated local drug and gene delivery using nanocarriers.

abstract：:Keratinases are proteolytic enzymes predominantly active when keratin substrates are available that attack disulfide bridges in the keratin to convert them from complex to simplified forms. Keratinases are essential in preparation of animal nutrients, protein supplements, leather manufacture, textile processing, deter...

journal_title：BioMed research international

authors： Gopinath SC,Anbu P,Lakshmipriya T,Tang TH,Chen Y,Hashim U,Ruslinda AR,Arshad MK

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Macrosomia has become a worldwide problem with the rapid economic growth in the past few years. However, the detailed mechanism of how the macrosomia happened remains unknown. Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis. We hypothesized that serum miRNAs are poten...

journal_title：BioMed research international

authors： Hu L,Han J,Zheng F,Ma H,Chen J,Jiang Y,Jiang H

更新日期：2014-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world. DM is seen associated with obesity and diabetic retinopathy (DR). In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking t...

journal_title：BioMed research international

authors： Rampogu S,Rampogu Lemuel M

更新日期：2016-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...

journal_title：BioMed research international

authors： Li J,Lu Y,Li N,Li P,Wang Z,Ting W,Liu X,Wu W

更新日期：2020-04-06 00:00:00

abstract：:Although multimodal therapies including surgery, chemotherapy, and radiotherapy have improved clinical outcomes of patients with bone and soft tissue sarcomas, the prognosis of patients has plateaued over these 20 years. Immunotherapies have shown the effectiveness for several types of advanced tumors. Immunotherapies...

journal_title：BioMed research international

authors： Uehara T,Fujiwara T,Takeda K,Kunisada T,Ozaki T,Udono H

更新日期：2015-01-01 00:00:00

abstract：:We have evaluated the cloning and functional expression of previously described broad antimicrobial spectrum bacteriocins SRCAM 602, OR-7, E-760, and L-1077, by recombinant Pichia pastoris. Synthetic genes, matching the codon usage of P. pastoris, were designed from the known mature amino acid sequence of these bacter...

journal_title：BioMed research international

authors： Arbulu S,Jiménez JJ,Gútiez L,Cintas LM,Herranz C,Hernández PE

更新日期：2015-01-01 00:00:00

abstract：:Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediter...

journal_title：BioMed research international

authors： Karygianni L,Cecere M,Skaltsounis AL,Argyropoulou A,Hellwig E,Aligiannis N,Wittmer A,Al-Ahmad A

更新日期：2014-01-01 00:00:00

abstract：:A series of amides derived from vanillic acid were obtained by coupling reactions using PyBOP ((Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate) and DCC (Dicyclohexylcarbodiimide) coupling reagents. These were submitted to biological evaluation for species of Candida, Staphylococcus, and Pseudomonas...

journal_title：BioMed research international

authors： Santos Oliveira AJM,de Castro RD,Pessôa HLF,Wadood A,de Sousa DP

更新日期：2019-04-15 00:00:00

abstract：:Synovitis plays an important role in the pathogenesis of arthritis, which is closely related to the joint swell and pain of patients. The purpose of this study was to investigate the anti-inflammatory effects of pulsed electromagnetic fields (PEMF) on synovitis and its underlying mechanisms. Destabilization of the med...

journal_title：BioMed research international

authors： Ouyang J,Zhang B,Kuang L,Yang P,Du X,Qi H,Su N,Jin M,Yang J,Xie Y,Tan Q,Chen H,Chen S,Jiang W,Liu M,Luo X,He M,Ni Z,Chen L

更新日期：2020-05-26 00:00:00

abstract：:Determination of the volumes of acute cerebral infarct in the magnetic resonance imaging harbors prognostic values. However, semiautomatic method of segmentation is time-consuming and with high interrater variability. Using diffusion weighted imaging and apparent diffusion coefficient map from patients with acute infa...

journal_title：BioMed research international

authors： Tsai JZ,Peng SJ,Chen YW,Wang KW,Wu HK,Lin YY,Lee YY,Chen CJ,Lin HJ,Smith EE,Yeh PS,Hsin YL

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer's disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). METHODS:The baseline sample of 18...

journal_title：BioMed research international

authors： Laske C,Sohrabi HR,Jasielec MS,Müller S,Koehler NK,Gräber S,Förster S,Drzezga A,Mueller-Sarnowski F,Danek A,Jucker M,Bateman RJ,Buckles V,Saykin AJ,Martins RN,Morris JC,Dominantly Inherited Alzheimer Network Dian

更新日期：2015-01-01 00:00:00

abstract：Background and Aims:The NF-κB pathway has been implicated in the genetic aetiology of psoriatic disease. However, since most patients with arthritis have psoriasis, discerning the genetic contributions to both aspects of psoriatic disease is not easy. Our aim was to study the association of common polymorphisms in gene...

journal_title：BioMed research international

authors： Coto-Segura P,Coto E,González-Lara L,Alonso B,Gómez J,Cuesta-Llavona E,Queiro R

更新日期：2019-11-11 00:00:00

abstract：:Carbonic anhydrases (CAs) are enzymes that catalyse the reversible hydration of CO2 to bicarbonate. CA XII is considered a potential biomarker of tumor cells and a promising target for specific therapies. The aim of the current study was to develop new monoclonal antibodies (MAbs) against human recombinant CA XII and ...

journal_title：BioMed research international

authors： Dekaminaviciute D,Lasickiene R,Parkkila S,Jogaite V,Matuliene J,Matulis D,Zvirbliene A

更新日期：2014-01-01 00:00:00

abstract：:We evaluated single nucleotide polymorphism (SNP) detection via a target-capture, C-probe ligation, and RAM assay in a single-blind comparison to clinical samples that had been tested with FDA-cleared tests for up to 4 different vascular disease-related SNPs. In the RAM assay circulizable linear probes (C- or padlock ...

journal_title：BioMed research international

authors： Smith JH,Cui M,Zhang DY,Beals TP,Ye F

更新日期：2014-01-01 00:00:00

abstract：:The similarity-based retrieval of lung nodule computed tomography (CT) images is an important task in the computer-aided diagnosis of lung lesions. It can provide similar clinical cases for physicians and help them make reliable clinical diagnostic decisions. However, when handling large-scale lung images with a gener...

journal_title：BioMed research international

authors： Pan L,Qiang Y,Yuan J,Wu L

更新日期：2016-01-01 00:00:00

abstract：Background and Aim:The incidence of nonalcoholic fatty liver disease (NAFLD) as a metabolic disease is increasing annually. In the present study, we aimed to explore the influence of NAFLD on the severity of acute pancreatitis (AP). Methods:The severity of AP was diagnosed and analyzed according to the 2012 revised At...

journal_title：BioMed research international

authors： Wu D,Zhang M,Xu S,Wu K,Wang N,Wang Y,Wu J,Lu G,Gong W,Ding Y,Xiao W

更新日期：2019-01-22 00:00:00

abstract：:Objectives. To construct a frailty index from next-of-kin information of the last year of life of community-dwelling 50 years old or older adults and test its association with health services utilization. Methods. Cross-sectional analysis from next-of-kin data available from the last wave of the Mexican Health and Agi...

journal_title：BioMed research international

authors： Pérez-Zepeda MU,Cesari M,Carrillo-Vega MF,Salinas-Escudero G,Tella-Vega P,García-Peña C

更新日期：2017-01-01 00:00:00

abstract：:Heart failure commonly results from an irreparable damage due to cardiovascular diseases (CVDs), the leading cause of morbidity and mortality in the United States. In recent years, the rapid advancements in stem cell research have garnered much praise for paving the way to novel therapies in reversing myocardial injur...

journal_title：BioMed research international

authors： Sheng CC,Zhou L,Hao J

更新日期：2013-01-01 00:00:00

abstract：:Uveitic glaucoma (UG) typically is associated with very high intraocular pressure (IOP) and more intense optic nerve damage than other glaucoma types. This secondary glaucoma requires an early diagnosis and adequate management of both uveitis and glaucoma. It is mandatory to identify the mechanisms of IOP elevation th...

journal_title：BioMed research international

authors： Muñoz-Negrete FJ,Moreno-Montañés J,Hernández-Martínez P,Rebolleda G

更新日期：2015-01-01 00:00:00

abstract：:The present study is designed to determine potential target genes involved in hepatocellular carcinoma (HCC) and provide possible underlying mechanisms of action. Several studies (GSE112790, GSE87630, and GSE56140) from the GEO database looking at molecular characteristics in HCC were screened and analyzed by GEO2R, w...

journal_title：BioMed research international

authors： Mu D,Qin F,Li B,Zhou Q

更新日期：2020-10-05 00:00:00

abstract：:Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Chinese Medicine (TCM...

journal_title：BioMed research international

authors： Hung TC,Lee WY,Chen KB,Chan YC,Chen CY

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Tuberculosis is still one of the most important health problems in developing countries and increasing drug resistance is the main concern for its treatment. This study was designed to characterize the drug resistant Mycobacterium tuberculosis isolated from patients suffering from pulmonary tuberculosis in...

journal_title：BioMed research international

authors： Tavanaee Sani A,Shakiba A,Salehi M,Bahrami Taghanaki HR,Ayati Fard SF,Ghazvini K

更新日期：2015-01-01 00:00:00

abstract：:This paper presents an ultrasound simulation model for pulsatile blood flow, modulated by the motion of a stenosed vessel wall. It aims at generating more realistic ultrasonic signals to provide an environment for evaluating ultrasound signal processing and imaging and a framework for investigating the behaviors of bl...

journal_title：BioMed research international

authors： Zhang Q,Zhang Y,Zhou Y,Zhang K,Zhang K,Gao L

更新日期：2016-01-01 00:00:00

abstract：Background:Ischemic heart disease (IHD) is the major cause of death in patients with cardiovascular disease. Cardiac remodeling is a common pathological change following myocardial infarction (MI), and cardiomyocyte apoptosis plays a key role in this change. Transcription factor recombination signal-binding protein-J (...

journal_title：BioMed research international

authors： He Y,Pang S,Huang J,Zhu K,Tong J,Tang Y,Ma G,Chen L

更新日期：2018-07-03 00:00:00

abstract：Purpose:This study aims to compare the functional outcomes of nonunion humeral diaphyseal fractures following conservative treatment when managed surgically with either a plate or intramedullary (IM) nail fixation. Methods:This was a retrospective study of 56 patients with nonunion humeral fractures following conserva...

journal_title：BioMed research international

authors： Micic I,Kholinne E,Kwak JM,Sun Y,Nanda A,Kim H,Koh KH,Jeon IH

更新日期：2019-07-22 00:00:00

abstract：:The polarization of macrophages and its anti-inflammatory and proinflammatory properties play a significant role in host response after implant placement to determine the outcome of osseointegration and long-term survival. In the previous study, we immobilized an antimicrobial peptide, GL13K, onto titanium surfaces to...

journal_title：BioMed research international

authors： Chen X,Zhou L,Wu D,Huang W,Lin Y,Zhou B,Chen J

更新日期：2020-07-24 00:00:00

abstract：:Human histone deacetylase 2 (HDAC2) has been identified as being associated with Alzheimer's disease (AD), a neuropathic degenerative disease. In this study, we screen the world's largest Traditional Chinese Medicine (TCM) database for natural compounds that may be useful as lead compounds in the search for inhibitors...

journal_title：BioMed research international

authors： Hung TC,Lee WY,Chen KB,Chan YC,Lee CC,Chen CY

更新日期：2014-01-01 00:00:00

abstract：:Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent stu...

journal_title：BioMed research international

authors： Gong D,Yu X,Wang L,Kong L,Gong X,Dong Q

更新日期：2017-01-01 00:00:00

abstract：:Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the...

journal_title：BioMed research international

authors： Rowdhwal SSS,Chen J

更新日期：2018-02-22 00:00:00

abstract：:SARS-CoV-2 pandemic and COVID-19 diffusion have recently become an international public health emergency. Cancer patients, as a frail population, are particularly exposed to the risk related to infections. The clinical decision-making process and the organizational workflow of radiotherapy department should be revised...

journal_title：BioMed research international

authors： Franco P,Kochbati L,Siano M,De Bari B

更新日期：2020-05-26 00:00:00