Abstract:
:Combination antiemetic regimens targeting multiple molecular pathways associated with emesis have become the standard of care for prevention of chemotherapy-induced nausea and vomiting (CINV) related to highly and moderately emetogenic chemotherapies. Antiemetic consensus guidelines from several professional societies are widely available and updated regularly as new data emerges. Unfortunately, despite substantial research supporting the notion that guideline conformity improves CINV control, adherence to antiemetic guidelines is unsatisfactory. While studies are needed to identify specific barriers to guideline use and explore measures to enhance adherence, a novel approach has been taken to improve clinician adherence and patient compliance, with the development of a new combination antiemetic. NEPA is an oral fixed combination of a new highly selective NK1 receptor antagonist (RA), netupitant, and the pharmacologically and clinically distinct 5-HT3 RA, palonosetron. This convenient antiemetic combination offers guideline-consistent prophylaxis by targeting two critical pathways associated with CINV in a single oral dose administered only once per cycle. This paper will review and discuss the NEPA data in the context of how this first combination antiemetic may overcome some of the barriers interfering with adherence to antiemetic guidelines, enhance patient compliance, and offer a possible advance in the prevention of CINV for patients.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Hesketh PJ,Aapro M,Jordan K,Schwartzberg L,Bosnjak S,Rugo Hdoi
10.1155/2015/651879subject
Has Abstractpub_date
2015-01-01 00:00:00pages
651879eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5280514
更新日期:2019-03-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8132676
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journal_title:BioMed research international
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abstract::The aim of this study is to investigate the stress distributions of different restoration options for class II mesio-occluso-distal (MOD) cavities. A class II MOD cavity with proximal box gingival floor 1 mm below cementoenamel junction was designed in a mandibular first molar tooth model. 3D finite-element analysis (...
journal_title:BioMed research international
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abstract:Objective:The exact shape of the dose-response relationship between maternal body mass index (BMI) and the risk of congenital heart defects (CHDs) in infants has not been clearly defined yet. This study aims to further clarify the relationship between maternal obesity and the risk of CHDs in infants by an overall and d...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/1315796
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2018-11-21 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/853602
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2015/898197
更新日期:2015-01-01 00:00:00
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doi:10.1155/2020/3607436
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pub_type: 杂志文章
doi:10.1155/2020/2616930
更新日期:2020-10-03 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7845904
更新日期:2018-07-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4585360
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/2868564
更新日期:2020-11-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3858465
更新日期:2020-02-12 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/519830
更新日期:2015-01-01 00:00:00
abstract:Introduction:Pulp regeneration, as a treatment for pulp necrosis, has significant advantages over root canal therapy for the preservation of living pulp. To date, research on pulp regeneration has mainly focused on the transplantation of pulp stem cells into the root canal, but there is still a lack of research on the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4759060
更新日期:2019-07-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3904139
更新日期:2018-02-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/547818
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/845041
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8459503
更新日期:2018-09-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/890803
更新日期:2013-01-01 00:00:00
abstract:Background:Reduced baroreflex sensitivity (BRS) has been reported in patients with acute cardiovascular events. We tested the hypothesis that BRS varies in different subtypes of acute ischemic stroke (AIS) and that BRS is a predictor of clinical outcomes. Methods:We examined autonomic parameters in 34 patients with AI...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7614828
更新日期:2019-04-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7948432
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367359
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2019/3176951
更新日期:2019-11-13 00:00:00
abstract::The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process. In this work, we present the characterization of the bacterial commu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/242856
更新日期:2015-01-01 00:00:00
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doi:10.1155/2014/471317
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pub_type: 杂志文章
doi:10.1155/2015/318364
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/297093
更新日期:2013-01-01 00:00:00