Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study.

Abstract:

:Immunodeficiency is associated with higher cancer incidence. However, it is unknown whether there is a link between immunodeficiency and development of multiple primary malignancies. In the present study we analyse this link focusing on kidney-transplanted patients, as they are at higher risk of developing cancer due to the chronic assumption of immunosuppressants. We followed up 1200 patients who underwent kidney transplantation between 1980 and 2012. A total of 77/1200 kidney-transplanted patients developed cancer and 24 of them developed multiple cancers. Most multiple cancers were synchronous with a nonsignificant association between cancer and rejection episodes. In the general cancer population, one-ninth of patients are at higher risk of developing a second tumor over a lifetime; hence it would be reasonable to conclude that, from a merely theoretical and statistical viewpoint, long-term transplanted patients potentially have a higher risk of developing MPMs. However, data did not confirm this assumption, probably because these patients die before a second primary malignancy appears. Despite many observations on the increased incidence of different tumor types in immunodeficient patients and despite immunosuppression certainly being a predisposing factor for the multicancer syndrome, data so far are not robust enough to justify a correlation between immunodeficiency and multiple primary malignancies in transplanted patients.

journal_name

Biomed Res Int

authors

Santangelo ML,Criscitiello C,Renda A,Federico S,Curigliano G,Dodaro C,Scotti A,Tammaro V,Calogero A,Riccio E,Pisani A,Carlomagno N

doi

10.1155/2015/183523

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

183523

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Acute Feasibility of Neuromuscular Electrical Stimulation in Severely Obese Patients with Obstructive Sleep Apnea Syndrome: A Pilot Study.

    abstract::Objective. Obesity and obstructive sleep apnea (OSA) are closely interconnected conditions both leading to high cardiovascular risk. Inactivity is frequent and physical activity programs remain difficult in these patients. We investigated the acute feasibility of two neuromuscular electrical stimulation (NMES) modalit...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2017/3704380

    authors: Vivodtzev I,Maffiuletti NA,Borel AL,Grangier A,Wuyam B,Tamisier R,Pépin JL

    更新日期:2017-01-01 00:00:00

  • Systemic treatment with strontium ranelate accelerates the filling of a bone defect and improves the material level properties of the healing bone.

    abstract::Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects o...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/549785

    authors: Zacchetti G,Dayer R,Rizzoli R,Ammann P

    更新日期:2014-01-01 00:00:00

  • Suppressive effects of D-glucosamine on the 5-HT sensitive nociceptive units in the rat tooth pulpal nerve.

    abstract::It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effect in treating oste...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/187989

    authors: Kaida K,Yamashita H,Toda K,Hayashi Y

    更新日期:2014-01-01 00:00:00

  • Rank-One and Transformed Sparse Decomposition for Dynamic Cardiac MRI.

    abstract::It is challenging and inspiring for us to achieve high spatiotemporal resolutions in dynamic cardiac magnetic resonance imaging (MRI). In this paper, we introduce two novel models and algorithms to reconstruct dynamic cardiac MRI data from under-sampled k - t space data. In contrast to classical low-rank and sparse mo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/169317

    authors: Xiu X,Kong L

    更新日期:2015-01-01 00:00:00

  • Behavioral Medicine Methods in Treatment of Somatic Conditions.

    abstract:Background:The aim of this article is to present a short review of noninvasive, nonpharmacological treatment methods used in somatic illnesses that fall under the umbrella of approach called behavioral medicine. Methods:The narrative review method was applied in the study. Science paper databases, including PubMed, ha...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/5076516

    authors: Białkowska J,Juranek J,Wojtkiewicz J

    更新日期:2020-11-03 00:00:00

  • 5-HT2B receptor antagonists inhibit fibrosis and protect from RV heart failure.

    abstract:OBJECTIVE:The serotonin (5-HT) pathway was shown to play a role in pulmonary hypertension (PH), but its functions in right ventricular failure (RVF) remain poorly understood. The aim of the current study was to investigate the effects of Terguride (5-HT2A and 2B receptor antagonist) or SB204741 (5-HT2B receptor antagon...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/438403

    authors: Janssen W,Schymura Y,Novoyatleva T,Kojonazarov B,Boehm M,Wietelmann A,Luitel H,Murmann K,Krompiec DR,Tretyn A,Pullamsetti SS,Weissmann N,Seeger W,Ghofrani HA,Schermuly RT

    更新日期:2015-01-01 00:00:00

  • Advanced Age as a Predictor of Survival and Weaning in Venoarterial Extracorporeal Oxygenation: A Retrospective Observational Study.

    abstract::Background. In most reports on ECMO treatment, advanced age is classified as a contraindication to VA ECMO. We attempted to investigate whether advanced age would be a main risk factor deciding VA ECMO application and performing VA ECMO support. We determined whether advanced age should be regarded as an absolute or r...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2017/3505784

    authors: Lee W,Kim Y,Choi H,Kim H,Lee S,Lee H,Chee H,Kim J,Hwang J,Lee S,Kim Y,Cho S,Ryu S,Park S

    更新日期:2017-01-01 00:00:00

  • Lactulose Hydrogen Breath Test Result Is Associated with Age and Gender.

    abstract::Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to la...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1064029

    authors: Newberry C,Tierney A,Pickett-Blakely O

    更新日期:2016-01-01 00:00:00

  • Pandemic Avian Influenza and Intra/Interhaemagglutinin Subtype Electrostatic Variation among Viruses Isolated from Avian, Mammalian, and Human Hosts.

    abstract::Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-bindin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3870508

    authors: Righetto I,Filippini F

    更新日期:2018-05-17 00:00:00

  • Recombinant dense granular protein (GRA5) for detection of human toxoplasmosis by Western blot.

    abstract::Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/690529

    authors: Ching XT,Lau YL,Fong MY,Nissapatorn V,Andiappan H

    更新日期:2014-01-01 00:00:00

  • Predominance of Abdominal Visceral Adipose Tissue Reflects the Presence of Aortic Valve Calcification.

    abstract::Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2174657

    authors: Oikawa M,Owada T,Yamauchi H,Misaka T,Machii H,Yamaki T,Sugimoto K,Kunii H,Nakazato K,Suzuki H,Saitoh S,Takeishi Y

    更新日期:2016-01-01 00:00:00

  • Histochemical Study of the Rat Uterine Glycoconjugate Alteration following Treatment with Exogenous Gonadotropic Hormones during the Implantation Period.

    abstract::One of the female causes of infertility is anovulation which is treatable with gonadotropin hormones. These hormones affect the molecular organization of the uterus such as glycoconjugates that are the first site of contact between the blastocyst and the uterus. The objective of this project was to study the alteratio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3967427

    authors: Aliabadi E,Makoolati Z,Talaei-Khozani T,Ardekani FM,Aliabadi A

    更新日期:2020-12-04 00:00:00

  • Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose.

    abstract::VEGF-NO axis uncoupling is an important pathogenesis for DN. Reduced β2GPI could play a part in VEGF signaling pathway and has a protective effect on diabetic vascular disease. This study investigates the effect of reduced β2GPI on glomerular mesangial cells VEGF-NO axis uncoupling induced by high glucose. Compared to...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5484731

    authors: Saijun Z,Xin L,Jie W,Shumin X,Shuaihui L,Pei Y

    更新日期:2018-07-18 00:00:00

  • Relationship between Physical Activity and Physical Fitness in Preschool Children: A Cross-Sectional Study.

    abstract:Purpose:To evaluate the relationships between objectively measured physical activity and physical fitness among preschool children. Methods:A total of 346 participants (201 boys and 145 girls) aged 3.5-5.5 years (M = 4.5 yr, SD = 0.47) from Shanghai, China, completed physical fitness assessments, including triceps ski...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/9314026

    authors: Fang H,Quan M,Zhou T,Sun S,Zhang J,Zhang H,Cao Z,Zhao G,Wang R,Chen P

    更新日期:2017-01-01 00:00:00

  • Genetic Analysis of the Atrial Natriuretic Peptide Gene Polymorphisms among Essential Hypertensive Patients in Malaysia.

    abstract::Background. Atrial natriuretic peptide (ANP) considerably influences blood pressure regulation through water and sodium homoeostasis. Several of the studies have utilized anonymous genetic polymorphic markers and made inconsequent claims about the ANP relevant disorders. Thus, we screened Insertion/Deletion (ID) and G...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6712529

    authors: Ghodsian N,Ismail P,Ahmadloo S,Eskandarian N,Etemad A

    更新日期:2016-01-01 00:00:00

  • The Italian National External quality assessment program in molecular genetic testing: results of the VII round (2010-2011).

    abstract::Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity an...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/739010

    authors: Censi F,Tosto F,Floridia G,Marra M,Salvatore M,Baffico AM,Grasso M,Melis MA,Pelo E,Radice P,Ravani A,Rosatelli C,Resta N,Russo S,Seia M,Varesco L,Falbo V,Taruscio D

    更新日期:2013-01-01 00:00:00

  • A low-dose combination of fluvastatin and valsartan: a new "drug" and a new approach for decreasing the arterial age.

    abstract::We have developed a new "drug" and approach that appear to be effective in reducing arterial age. This "drug" represents a low, subtherapeutic dose of statin and sartan and particularly their low-dose combination. The improvement of arterial wall characteristics, also reflecting in a decrease of arterial age, was achi...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/235709

    authors: Janić M,Lunder M,Šabovič M

    更新日期:2015-01-01 00:00:00

  • Multisensory integration and internal models for sensing gravity effects in primates.

    abstract::Gravity is crucial for spatial perception, postural equilibrium, and movement generation. The vestibular apparatus is the main sensory system involved in monitoring gravity. Hair cells in the vestibular maculae respond to gravitoinertial forces, but they cannot distinguish between linear accelerations and changes of h...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/615854

    authors: Lacquaniti F,Bosco G,Gravano S,Indovina I,La Scaleia B,Maffei V,Zago M

    更新日期:2014-01-01 00:00:00

  • Enhancing Ecoefficiency in Shrimp Farming through Interconnected Ponds.

    abstract::The future development of shrimp farming needs to improve its ecoefficiency. The purpose of this study was to evaluate water quality, flows, and nitrogen balance and production parameters on a farm with interconnected pond design to improve the efficiency of the semi-intensive culture of Litopenaeus vannamei ponds. Th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/873748

    authors: Barraza-Guardado RH,Arreola-Lizárraga JA,Miranda-Baeza A,Juárez-García M,Juvera-Hoyos A,Casillas-Hernández R

    更新日期:2015-01-01 00:00:00

  • Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head.

    abstract:Background:Osteonecrosis of the femoral head (ONFH) is a challenge for surgeons and is still without effective treatment method. This study is aimed at evaluating the combined pharmacotherapy with alendronate and desferoxamine for preventing glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) and evaluatin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3120458

    authors: Sheng H,Lao Y,Zhang S,Ding W,Lu D,Xu B

    更新日期:2020-09-21 00:00:00

  • Brain-Derived Neurotropic Factor Val66Met Polymorphism and Posttraumatic Stress Disorder among Survivors of the 1998 Dongting Lake Flood in China.

    abstract:OBJECTIVE:This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. METHODS:Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2017/4569698

    authors: Dai W,Kaminga AC,Wu X,Wen SW,Tan H,Yan J,Deng J,Lai Z,Liu A

    更新日期:2017-01-01 00:00:00

  • Monitoring the modifications of the vitreous humor metabolite profile after death: an animal model.

    abstract::We applied a metabolomic approach to monitor the modifications occurring in goat vitreous humor (VH) metabolite composition at different times (0, 6, 12, 18, and 24 hours) after death. The (1)H-NMR analysis of the VH samples was performed for the simultaneous determination of several metabolites (i.e., the metabolite ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/627201

    authors: Rosa MF,Scano P,Noto A,Nioi M,Sanna R,Paribello F,De-Giorgio F,Locci E,d'Aloja E

    更新日期:2015-01-01 00:00:00

  • Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization.

    abstract::POZ/BTB domains are widespread modules detected in a variety of different biological contexts. Here, we report a biophysical characterization of the POZ/BTB of KCTD6, a protein that is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradatio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/162674

    authors: Pirone L,Esposito C,Correale S,Graziano G,Di Gaetano S,Vitagliano L,Pedone E

    更新日期:2013-01-01 00:00:00

  • The Roles of Environmental Factors in Regulation of Oxidative Stress in Plant.

    abstract::Exposure to a variety of environmental factors such as salinity, drought, metal toxicity, extreme temperature, air pollutants, ultraviolet-B (UV-B) radiation, pesticides, and pathogen infection leads to subject oxidative stress in plants, which in turn affects multiple biological processes via reactive oxygen species ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9732325

    authors: Xie X,He Z,Chen N,Tang Z,Wang Q,Cai Y

    更新日期:2019-05-08 00:00:00

  • Caudal Epidural Block: An Updated Review of Anatomy and Techniques.

    abstract::Caudal epidural block is a commonly used technique for surgical anesthesia in children and chronic pain management in adults. It is performed by inserting a needle through the sacral hiatus to gain entrance into the sacral epidural space. Using conventional blind technique, the failure rate of caudal epidural block in...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9217145

    authors: Kao SC,Lin CS

    更新日期:2017-01-01 00:00:00

  • Improved efficacy of transcatheter arterial chemoembolization using warmed miriplatin for hepatocellular carcinoma.

    abstract::The aim of this study was to evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) using warmed and nonwarmed miriplatin for hepatocellular carcinoma. Eighty patients (117 nodules), treated between January 2010 and June 2013, were evaluated. Thirty-two and 85 nodules were treated with non...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/359296

    authors: Yasui D,Murata S,Onozawa S,Mine T,Ueda T,Sugihara F,Kawamoto C,Uchida E,Kumita S

    更新日期:2014-01-01 00:00:00

  • Diffusion tensor histogram analysis of pediatric diffuse intrinsic pontine glioma.

    abstract:PURPOSE:To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS:DTI was performed on a 1.5T GE...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/647356

    authors: Steffen-Smith EA,Sarlls JE,Pierpaoli C,Shih JH,Bent RS,Walker L,Warren KE

    更新日期:2014-01-01 00:00:00

  • AQUACEL® Ag Surgical Dressing Reduces Surgical Site Infection and Improves Patient Satisfaction in Minimally Invasive Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.

    abstract::The use of modern surgical dressings to prevent wound complications and surgical site infection (SSI) after minimally invasive total knee arthroplasty (MIS-TKA) is lacking. In a prospective, randomized, controlled study, 240 patients were randomized to receive either AQUACEL Ag Surgical dressing (study group) or a sta...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2017/1262108

    authors: Kuo FC,Chen B,Lee MS,Yen SH,Wang JW

    更新日期:2017-01-01 00:00:00

  • The effect of created local hyperosmotic microenvironment in microcapsule for the growth and metabolism of osmotolerant yeast Candida krusei.

    abstract::Candida krusei is osmotolerant yeast used for the production of glycerol. Addition of osmolyte such as NaCl into culture medium can increase the production of glycerol from glucose, but osmolytes may burden the glycerol separation. A coencapsulation method was suggested to create local extracellular hyperosmotic stres...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/467263

    authors: Chen G,Yao S

    更新日期:2013-01-01 00:00:00

  • Prevalence of Helicobacter pylori vacA Genotypes and cagA Gene in Dental Plaque of Asymptomatic Mexican Children.

    abstract::The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4923640

    authors: Mendoza-Cantú A,Urrutia-Baca VH,Urbina-Ríos CS,De la Garza-Ramos MA,García-Martínez ME,Torre-Martínez HHH

    更新日期:2017-01-01 00:00:00