Genetic Analysis of the Atrial Natriuretic Peptide Gene Polymorphisms among Essential Hypertensive Patients in Malaysia.

Abstract:

:Background. Atrial natriuretic peptide (ANP) considerably influences blood pressure regulation through water and sodium homoeostasis. Several of the studies have utilized anonymous genetic polymorphic markers and made inconsequent claims about the ANP relevant disorders. Thus, we screened Insertion/Deletion (ID) and G191A polymorphisms of ANP to discover sequence variations with potential functional significance and to specify the linkage disequilibrium pattern between polymorphisms. The relationships of detected polymorphisms with EH with or without Type 2 Diabetes Mellitus (T2DM) status were tested subsequently. Method. ANP gene polymorphisms (I/D and A191G) were specified utilizing mutagenically separated Polymerase Chain Reaction (PCR) in 320 subjects including 163 EH case subjects and 157 controls. Result. This case-control study discovered a significant association between I/D polymorphisms of ANP gene in EH patient without T2DM. However, the study determined no association between G191A polymorphisms of ANP in EH with or without T2DM. In addition, sociodemographic factors in the case and healthy subjects exhibited strong differences (P < 0.05). Conclusion. As a risk factor, ANP gene polymorphisms may affect hypertension. Despite the small sample size in this study, it is the first research assessing the ANP gene polymorphisms in both EH and T2DM patients among Malaysian population.

journal_name

Biomed Res Int

authors

Ghodsian N,Ismail P,Ahmadloo S,Eskandarian N,Etemad A

doi

10.1155/2016/6712529

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

6712529

eissn

2314-6133

issn

2314-6141

journal_volume

2016

pub_type

杂志文章
  • Network analysis of neurodegenerative disease highlights a role of Toll-like receptor signaling.

    abstract::Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions between diseases are not always entirely clear. We present an efficient computational method based on protein-protei...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/686505

    authors: Nguyen TP,Caberlotto L,Morine MJ,Priami C

    更新日期:2014-01-01 00:00:00

  • The association between autoantibodies and peripheral neuropathy in lupus nephritis.

    abstract:BACKGROUND AND AIM:The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. METHODS:Dat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/524940

    authors: Su YJ,Huang CR,Chang WN,Tsai NW,Kung CT,Lin WC,Huang CC,Su CM,Cheng BC,Chang YT,Lu CH

    更新日期:2014-01-01 00:00:00

  • Early Recovery of Exercise-Related Muscular Injury by HBOT.

    abstract::Early recovery from muscular injury is crucial for elite athletes. Hyperbaric oxygen therapy (HBOT) has been reported to be beneficial in terms of accelerating cell recovery and tissue repair, which are considered to be helpful for eliminating fatigue and recovering stamina. This study was performed to evaluate the ef...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/6289380

    authors: Chen CY,Chou WY,Ko JY,Lee MS,Wu RW

    更新日期:2019-05-29 00:00:00

  • Differential response of oyster shell powder on enzyme profile and nutritional value of oyster mushroom Pleurotus florida PF05.

    abstract::Oyster mushroom Pleurotus florida was cultivated on different combinations of wheat straw (WS) as basal substrate and oyster shell powder (OSP) supplement. The OSP supplementation considerably responded to different cultivation phases. The mycelium grew fast and showed rapid growth rate (8.91 mmd(-1)) in WS + OSP (97 ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/386265

    authors: Naraian R,Narayan OP,Srivastava J

    更新日期:2014-01-01 00:00:00

  • Emergency versus Elective Cervical Cerclage: An Audit of Our First Two Years of Service.

    abstract::One of the biggest obstetric challenges is the diagnosis and management of a short cervix as cervical length has an inverse relationship with risk of preterm birth. A cervical cerclage is a surgical procedure to reduce the risk of preterm birth and can be placed in an elective or emergency setting. This is a retrospec...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2018/2065232

    authors: Vasudeva N,Reddington C,Bogdanska M,De Luca L

    更新日期:2018-09-30 00:00:00

  • Can the Diagnostics of Triangular Fibrocartilage Complex Lesions Be Improved by MRI-Based Soft-Tissue Reconstruction? An Imaging-Based Workup and Case Presentation.

    abstract::Introduction. The triangular fibrocartilage complex (TFCC) provides both mobility and stability of the radiocarpal joint. TFCC lesions are difficult to diagnose due to the complex anatomy. The standard treatment for TFCC lesions is arthroscopy, posing surgery-related risks onto the patients. This feasibility study aim...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/5870875

    authors: Hammer N,Hirschfeld U,Strunz H,Werner M,Wolfskämpf T,Löffler S

    更新日期:2017-01-01 00:00:00

  • The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study.

    abstract:Introduction:The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6038106

    authors: Kuciel-Lewandowska J,Gnus J,Pawlik-Sobecka L,Płaczkowska S,Kokot I,Kasperczak M,Paprocka-Borowicz M

    更新日期:2018-01-02 00:00:00

  • The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease. NAFLD encompasses a wide range of pathologies, from simple steatosis to steatosis with inflammation to fibrosis. The pathogenesis of NAFLD progression has not been completely elucidated, and different liver cells could be imp...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/768071

    authors: Almeda-Valdes P,Aguilar Olivos NE,Barranco-Fragoso B,Uribe M,Méndez-Sánchez N

    更新日期:2015-01-01 00:00:00

  • MediterrAsian Diet Products That Could Raise HDL-Cholesterol: A Systematic Review.

    abstract::Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjec...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2025687

    authors: Rondanelli M,Giacosa A,Morazzoni P,Guido D,Grassi M,Morandi G,Bologna C,Riva A,Allegrini P,Perna S

    更新日期:2016-01-01 00:00:00

  • Newborn first feed and prelacteal feeds in Mansoura, Egypt.

    abstract:BACKGROUND:Prelacteal feed (feeding any other substance before first breastfeeding) appears to be common despite its harmful effects. By definition a child provided with prelacteal feed (PLF) is not exclusively breastfed and PLF has many implications for the success and early initiation of breastfeeding. Objectives. To...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/258470

    authors: El-Gilany AH,Abdel-Hady DM

    更新日期:2014-01-01 00:00:00

  • Multiorgan Drug Action of Levosimendan in Critical Illnesses.

    abstract::Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors, and calcium sensitizers, which have been successively discovered and applied in clinical practice. However, there are only a few new drugs available in this field, and the selection is very limited. Digitalis, catecholamines, and...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9731467

    authors: Pan J,Yang YM,Zhu JY,Lu YQ

    更新日期:2019-09-19 00:00:00

  • A Decade of Progress Using Virtual Reality for Poststroke Lower Extremity Rehabilitation: Systematic Review of the Intervention Methods.

    abstract:OBJECTIVE:To develop a systematic review of the literature, to describe the different virtual reality (VR) interventions and interactive videogames applied to the lower extremity (LE) of stroke patients, and to analyse the results according to the most frequently used outcome measures. MATERIAL AND METHODS:An electron...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/342529

    authors: Luque-Moreno C,Ferragut-Garcías A,Rodríguez-Blanco C,Heredia-Rizo AM,Oliva-Pascual-Vaca J,Kiper P,Oliva-Pascual-Vaca Á

    更新日期:2015-01-01 00:00:00

  • Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5/p35-NMDAR-IDE Pathway.

    abstract::The relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) has attracted wide attention. Studies have reported that ginsenoside Rb1 can improve human cognitive ability and glucose tolerance during the development of diabetes. The mechanism behind the improvement in cognitive ability and glucose toler...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3905719

    authors: Yang R,Jiang X,He X,Liang D,Sun S,Zhou G

    更新日期:2020-05-20 00:00:00

  • Radiopharmaceutical stem cell tracking for neurological diseases.

    abstract::Although neurological ailments continue to be some of the main causes of disease burden in the world, current therapies such as pharmacological agents have limited potential in the restoration of neural functions. Cell therapies, firstly applied to treat different hematological diseases, are now being investigated in ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/417091

    authors: Rosado-de-Castro PH,Pimentel-Coelho PM,Gutfilen B,Lopes de Souza SA,de Freitas GR,Mendez-Otero R,Barbosa da Fonseca LM

    更新日期:2014-01-01 00:00:00

  • Environmental Kuznets curve analysis of the economic development and nonpoint source pollution in the Ningxia Yellow River irrigation districts in China.

    abstract::This study applies the environmental Kuznets curve to test the relationship between the regional economic growth and the different types of agricultural nonpoint source pollution loads in the Ningxia Yellow River irrigation area by using the Johnes export coefficient method. Results show that the pollution load genera...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/267968

    authors: Mao C,Zhai N,Yang J,Feng Y,Cao Y,Han X,Ren G,Yang G,Meng QX

    更新日期:2013-01-01 00:00:00

  • Hemodynamic and tubular changes induced by contrast media.

    abstract::The incidence of acute kidney injury induced by contrast media (CI-AKI) is the third cause of AKI in hospitalized patients. Contrast media cause relevant alterations both in renal hemodynamics and in renal tubular cell function that lead to CI-AKI. The vasoconstriction of intrarenal vasculature is the main hemodynamic...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/578974

    authors: Caiazza A,Russo L,Sabbatini M,Russo D

    更新日期:2014-01-01 00:00:00

  • T Helper Lymphocyte Subsets and Plasticity in Autoimmunity and Cancer: An Overview.

    abstract::In response to cytokine signalling and other factors, CD4-positive T lymphocytes differentiate into distinct populations that are characterized by the production of certain cytokines and are controlled by different master transcription factors. The spectrum of such populations, which was initially limited to Th1 and T...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/327470

    authors: Ivanova EA,Orekhov AN

    更新日期:2015-01-01 00:00:00

  • Endoscopic sphincterotomy with large balloon dilation versus endoscopic sphincterotomy for bile duct stones: a systematic review and meta-analysis.

    abstract:UNLABELLED:The safety and efficacy of endoscopic sphincterotomy with large balloon dilation (EPLBD) are unclear. This study compares the safety and efficacy between EPLBD and endoscopic sphincterotomy (EST). PATIENTS AND METHODS:Literatures were searched for randomized controlled trials in PUBMED, EMBASE, and Cochrane...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2015/673103

    authors: Xu L,Kyaw MH,Tse YK,Lau JY

    更新日期:2015-01-01 00:00:00

  • Biochemical and Molecular Phylogenetic Study of Agriculturally Useful Association of a Nitrogen-Fixing Cyanobacterium and Nodule Sinorhizobium with Medicago sativa L.

    abstract::Seed inoculation with bacterial consortium was found to increase legume yield, providing a higher growth than the standard nitrogen treatment methods. Alfalfa plants were inoculated by mono- and binary compositions of nitrogen-fixing microorganisms. Their physiological and biochemical properties were estimated. Inocul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/202597

    authors: Karaushu EV,Lazebnaya IV,Kravzova TR,Vorobey NA,Lazebny OE,Kiriziy DA,Olkhovich OP,Taran NY,Kots SY,Popova AA,Omarova E,Koksharova OA

    更新日期:2015-01-01 00:00:00

  • Autophagy, Warburg, and Warburg reverse effects in human cancer.

    abstract::Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanism...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/926729

    authors: Gonzalez CD,Alvarez S,Ropolo A,Rosenzvit C,Bagnes MF,Vaccaro MI

    更新日期:2014-01-01 00:00:00

  • Vulnerability assessment and application of bacterial technology on urban rivers for pollution eradication.

    abstract::To protect against the environmental pollution, the present research was undertaken to enumerate the Bacterial Technologies (BTs) on the restoration of polluted urban rivers, that is, Fenghu-Song Yang River (FSR) and Xuxi River (XXR). Experimental research accounted for the physiochemical parameters (pH; temperature; ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/241769

    authors: Hashim S,Yuebo X,Ahmad F,Arslan C,Saifullah M

    更新日期:2015-01-01 00:00:00

  • Modulation of the rat hepatic cytochrome P4501A subfamily using biotin supplementation.

    abstract::Studies have found that biotin favors glucose and lipid metabolism, and medications containing biotin have been developed. Despite the use of biotin as a pharmacological agent, few studies have addressed toxicity aspects including the possible interaction with cytochrome P450 enzyme family. This study analyzed the eff...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/627907

    authors: Ronquillo-Sánchez MD,Camacho-Carranza R,Fernandez-Mejia C,Hernández-Ojeda S,Elinos-Baez M,Espinosa-Aguirre JJ

    更新日期:2013-01-01 00:00:00

  • Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease.

    abstract::The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis t...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/709846

    authors: Flávia Nardy A,Santos L,Freire-de-Lima CG,Morrot A

    更新日期:2015-01-01 00:00:00

  • Attitude of Jordanian Physicians toward Biochemistry and Genetics.

    abstract:Background:Several studies found that physicians develop a negative attitude toward biochemistry and genetics disciplines. Many medical schools adopt an integrated system-based curriculum supplemented with clinical correlations. Medical schools in Jordan switched to the integrated curriculum; however, studies that eval...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3176951

    authors: Alfaqih MA,Khader YS,Bashir N,Nusair Z,Nuseir Q,Nusier M

    更新日期:2019-11-13 00:00:00

  • Comparison of the Effect of Vaginal Zataria multiflora Cream and Oral Metronidazole Pill on Results of Treatments for Vaginal Infections including Trichomoniasis and Bacterial Vaginosis in Women of Reproductive Age.

    abstract::Effect of Zataria multiflora on bacterial vaginosis and Trichomonas vaginalis is shown in vivo and in vitro. We compare the effectiveness of Zataria multiflora cream and oral metronidazole pill on results of treatment for vaginal infections including Trichomonas and bacterial vaginosis; these infections occur simultan...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/683640

    authors: Abdali K,Jahed L,Amooee S,Zarshenas M,Tabatabaee H,Bekhradi R

    更新日期:2015-01-01 00:00:00

  • Comparing microspheres with different internal phase of polyelectrolyte as local drug delivery system for bone tuberculosis therapy.

    abstract::We use hydrophobic poly(lactic-co-glycolic) acid (PLGA) to encapsulate hydrophilic ofloxacin to form drug loading microspheres. Hyaluronic acid (HA) and polylysine (Pls) were used as internal phase additives to see their influences on the drug loading and releasing. Double emulsion (water-in-oil-in-water) solvent extr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/297808

    authors: Wu G,Chen L,Li H,Deng CL,Chen XF

    更新日期:2014-01-01 00:00:00

  • Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries.

    abstract:OBJECTIVE:Abnormal expression of ABCA1 and ABCG1 in the placenta can elicit lipid metabolism disorder and adverse pregnancy outcomes. However, whether it is associated with preterm delivery remains unclear. Our present study aimed to evaluate the relationship between abnormal expression of ABCA1 or ABCG1 and preterm de...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2017/8248094

    authors: Cheng-Mao X,Yan L,Li L,Hua J,Xiao-Ju W,Jie-Wen Z

    更新日期:2017-01-01 00:00:00

  • Microcystins Presence in Mussels (M. galloprovincialis) and Water of Two Productive Mediterranean's Lagoons (Sardinia, Italy).

    abstract::Microcystins (MCs) are hepatotoxins harmful for animal and human health. The most toxic type between them is MC-LR whose presence has been investigated in different reservoirs all around the world. In this work microcystins were monitored in spring and summer in water and mussels (Mytilus galloprovincialis) of two Sar...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/3769245

    authors: Baralla E,Varoni MV,Sedda T,Pasciu V,Floris A,Demontis MP

    更新日期:2017-01-01 00:00:00

  • Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.

    abstract::It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/182846

    authors: Chen MF,Tsai JT,Chen LJ,Wu TP,Yang JJ,Yin LT,Yang YL,Chiang TA,Lu HL,Wu MC

    更新日期:2014-01-01 00:00:00

  • Roles of pRB in the Regulation of Nucleosome and Chromatin Structures.

    abstract::Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleosomes and/or chromos...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5959721

    authors: Uchida C

    更新日期:2016-01-01 00:00:00