Network analysis of neurodegenerative disease highlights a role of Toll-like receptor signaling.

abstract：Background:The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). Abundant evidence indicates that abnormal expression of Pc proteins is associated with a variety of tumors, but their role in the pathogen...

journal_title：BioMed research international

authors： Tan C,Bei C,Zhu X,Zhang Y,Qin L,Tan S

更新日期：2019-05-09 00:00:00

abstract：Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...

journal_title：BioMed research international

authors： Wu X,Sun W,Tan M

更新日期：2019-11-26 00:00:00

abstract：:This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and ...

journal_title：BioMed research international

authors： Tang M,Ou N,Li C,Lu A,Li J,Ma L,Zhong W,Gao J,Zheng Y,Cai Y

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...

journal_title：BioMed research international

authors： Wangerin H,Kristiansen G,Schlomm T,Stephan C,Gunia S,Zimpfer A,Weichert W,Sauter G,Erbersdobler A

更新日期：2014-01-01 00:00:00

abstract：:Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-bindin...

journal_title：BioMed research international

authors： Righetto I,Filippini F

更新日期：2018-05-17 00:00:00

abstract：:Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. A large number of studies demonstrated the association of low vitamin D levels and variations in five common single nucl...

journal_title：BioMed research international

authors： Suksawatamnuay S,Sriphoosanaphan S,Aumpansub P,Aniwan S,Thanapirom K,Tanasanvimon S,Thaimai P,Wiangngoen S,Ponauthai Y,Sumdin S,Angspatt P,Rerknimitr R,Poovorawan Y,Komolmit P

更新日期：2020-06-15 00:00:00

abstract：:28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15...

journal_title：BioMed research international

authors： Johari SA,Mohtar M,Mohammad SA,Sahdan R,Shaameri Z,Hamzah AS,Mohammat MF

更新日期：2015-01-01 00:00:00

abstract：:Tracking individual-cell/object over time is important in understanding drug treatment effects on cancer cells and video surveillance. A fundamental problem of individual-cell/object tracking is to simultaneously address the cell/object appearance variations caused by intrinsic and extrinsic factors. In this paper, in...

journal_title：BioMed research international

authors： Zhong B,Pan S,Wang C,Wang T,Du J,Chen D,Cao L

更新日期：2016-01-01 00:00:00

abstract：:Dietary polyphenols present in a broad range of plant foods have been related to beneficial health effects. This review aims to update the current information about the modulation of the gut microbiota by dietary phenolic compounds, from a perspective based on the experimental approaches used. After referring to gener...

journal_title：BioMed research international

authors： Dueñas M,Muñoz-González I,Cueva C,Jiménez-Girón A,Sánchez-Patán F,Santos-Buelga C,Moreno-Arribas MV,Bartolomé B

更新日期：2015-01-01 00:00:00

abstract：:Excessive ethanol consumption is one of the main causes of liver fibrosis. However, direct effects of ethanol exposure on endothelial cells and their contribution to fibrogenesis and metastasis were not investigated. Therefore we analysed whether ethanol directly affects endothelial cells and if this plays a role duri...

journal_title：BioMed research international

authors： Raskopf E,Gonzalez Carmona MA,Van Cayzeele CJ,Strassburg C,Sauerbruch T,Schmitz V

更新日期：2014-01-01 00:00:00

abstract：:The pathogenesis of intractable epilepsy is not fully clear. In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites tha...

journal_title：BioMed research international

authors： Xiong J,Mao DA,Liu LQ

更新日期：2015-01-01 00:00:00

abstract：:The craniofacial complex is the billboard of sorts containing information about sex, health, ancestry, kinship, genes, and environment. A thorough knowledge of the genes underlying craniofacial morphology is fundamental to understanding craniofacial biology and evolution. These genes can also provide an important foun...

journal_title：BioMed research international

authors： Roosenboom J,Hens G,Mattern BC,Shriver MD,Claes P

更新日期：2016-01-01 00:00:00

abstract：:Breast cancer is the leading cause of death in women worldwide. The search for novel compounds with antitumor activity, with less adverse effects and higher efficacy, and the development of methods to evaluate their toxicity is an area of intense research. In this study we implemented the preparation and culture of br...

journal_title：BioMed research international

authors： Carranza-Torres IE,Guzmán-Delgado NE,Coronado-Martínez C,Bañuelos-García JI,Viveros-Valdez E,Morán-Martínez J,Carranza-Rosales P

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Vasculogenic mimicry (VM) was related to invasion and metastasis of head and neck squamous cell carcinoma (HNSCC) patients. This study was designed to investigate the role of EphA2 in VM formation of HNSCC. METHODS:The SiRNA technique was used to knock down the expression of EphA2 in vitro. The ability of cell...

journal_title：BioMed research international

authors： Wang W,Lin P,Sun B,Zhang S,Cai W,Han C,Li L,Lu H,Zhao X

更新日期：2014-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are involved in the remodeling of extracellular matrix in various tissues. Their functioning could be related to the formation of complexes, containing MMP9, MMP2, tissue inhibitor of metalloproteinases type 1 (TIMP1), and neutrophil gelatinase-associated lipocalin (NGAL). Such complex...

journal_title：BioMed research international

authors： Kiczak L,Tomaszek A,Bania J,Paslawska U,Zacharski M,Noszczyk-Nowak A,Janiszewski A,Skrzypczak P,Ardehali H,Jankowska EA,Ponikowski P

更新日期：2013-01-01 00:00:00

abstract：:Introduction. Pelvic organ prolapse (POP) and urinary incontinence (UI) have increasing prevalence in the elderly population. The aim of this study was to compare the comorbidities of these procedures between <70 y/o and ≥70 y/o patients. Materials and Methods. In our retrospective study over a period of 2.5 years, 40...

journal_title：BioMed research international

authors： Joukhadar R,Wöckel A,Herr D,Paulus V,Radosa J,Hamza A,Solomayer E,Baum S

更新日期：2016-01-01 00:00:00

abstract：:Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy placental function is the proper development of its vascular network. Poor vascularization of the placenta can lead to fetal growth restriction, preeclampsia, and in so...

journal_title：BioMed research international

authors： Pereira RD,De Long NE,Wang RC,Yazdi FT,Holloway AC,Raha S

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the role of gender as a potential predictor of health behaviour and potential moderator of the relationship between emotional intelligence and health behaviour. This cross-sectional study included 1214 students (597 males and 617 females). Data were collected using the Schutte Self-Report Inven...

journal_title：BioMed research international

authors： Malinauskas R,Dumciene A,Sipaviciene S,Malinauskiene V

更新日期：2018-06-04 00:00:00

abstract：:Effects of in ovo injection of Q10 on hatchability, performance (feed intake (FI), body weight gain (BWG), feed/gain ratio (F/G)) traits, and immune status of Ross × Ross 308 broiler chicks, hatched from eggs laid by a 38-week-old breeder flock, were determined through 42 days after hatch. Eggs containing live embryos...

journal_title：BioMed research international

authors： Kalantar M,Hosseini SM,Hosseini MR,Kalantar MH,Farmanullah,Yang LG

更新日期：2019-02-04 00:00:00

abstract：:In previous studies, we have demonstrated the function of uc.167 in the heart development. DNA methylation plays a crucial role in regulating the expression of developmental genes during embryonic development. In this study, the methylomic landscape was investigated in order to identify the DNA methylation alterations...

journal_title：BioMed research international

authors： Yin A,Feng M,Cheng Z,Zhang Q,Li H,Xu J,Zhang H,Li Y,Qian L

更新日期：2018-05-30 00:00:00

abstract：:Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the secretome from the following informative cervical cell lines: SiHa (HPV16+), HeLa...

journal_title：BioMed research international

authors： Kontostathi G,Zoidakis J,Makridakis M,Lygirou V,Mermelekas G,Papadopoulos T,Vougas K,Vlamis-Gardikas A,Drakakis P,Loutradis D,Vlahou A,Anagnou NP,Pappa KI

更新日期：2017-01-01 00:00:00

abstract：Objective:Our aim was the development and validation of a modular signal processing and classification application enabling online electroencephalography (EEG) signal processing on off-the-shelf mobile Android devices. The software application SCALA (Signal ProCessing and CLassification on Android) supports a standardi...

journal_title：BioMed research international

authors： Blum S,Debener S,Emkes R,Volkening N,Fudickar S,Bleichner MG

更新日期：2017-01-01 00:00:00

abstract：:Three novel low molecular weight polysaccharides (RLP-1a, RLP-2a, and RLP-3a) with 9004, 8761, and 7571 Da were first obtained by purifying the crude polysaccharides from the fruits of a traditional Chinese medicinal herb Rosae Laevigatae. The conditions for polysaccharides from the R. Laevigatae fruit (RLP) extractio...

journal_title：BioMed research international

authors： Zhang X,Hu Y,Jin C,Wu W

更新日期：2020-10-22 00:00:00

abstract：:Hilar cholangiocarcinoma (HCC) remains one of the most difficult tumors to stage and treat. The aim of the study was to assess the diagnostic efficiency of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computer tomography (PET/CT) in evaluating the resectability of HCC. A...

journal_title：BioMed research international

authors： Zhang H,Zhu J,Ke F,Weng M,Wu X,Li M,Quan Z,Liu Y,Zhang Y,Gong W

更新日期：2015-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic degenerative joint disease, where chondrocyte apoptosis is responsible for cartilage degeneration. Bax is a well-known proapoptotic protein of the Bcl-2 family, involved in a large number of physiological and pathological processes. However, the regulation mechanisms of Bax underlying ...

journal_title：BioMed research international

authors： Miao G,Zang X,Hou H,Sun H,Wang L,Zhang T,Tan Y,Liu W,Ye P,Gao L,Zha Z

更新日期：2019-03-12 00:00:00

abstract：PURPOSE:Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase Cγ-1 (PLCγ-1), a key downstream mediator of the hepatocyte growth factor (HGF)/C-MET axis. Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast c...

journal_title：BioMed research international

authors： Sasi W,Ye L,Jiang WG,Sharma AK,Mokbel K

更新日期：2014-01-01 00:00:00

abstract：:Several factors, including compressive load and knee kinematics, have been shown to influence wear. External knee moments (a surrogate for load) have recently been correlated with the medial and lateral wear scar areas of an unconstrained, PCL retaining knee design. Therefore, the purpose of this study was to determin...

journal_title：BioMed research international

authors： Ngai V,Wimmer MA

更新日期：2015-01-01 00:00:00

abstract：Background and Aim:The incidence of nonalcoholic fatty liver disease (NAFLD) as a metabolic disease is increasing annually. In the present study, we aimed to explore the influence of NAFLD on the severity of acute pancreatitis (AP). Methods:The severity of AP was diagnosed and analyzed according to the 2012 revised At...

journal_title：BioMed research international

authors： Wu D,Zhang M,Xu S,Wu K,Wang N,Wang Y,Wu J,Lu G,Gong W,Ding Y,Xiao W

更新日期：2019-01-22 00:00:00

abstract：:Lung illness encountered in patients with rheumatic diseases bears clinical significance in terms of increased morbidity and mortality as well as potential challenges placed on patient care. Although our understanding of natural history of this important illness is still limited, epidemiologic knowledge has been accum...

journal_title：BioMed research international

authors： Ha YJ,Lee YJ,Kang EH

更新日期：2018-05-08 00:00:00

abstract：:Studies have found that biotin favors glucose and lipid metabolism, and medications containing biotin have been developed. Despite the use of biotin as a pharmacological agent, few studies have addressed toxicity aspects including the possible interaction with cytochrome P450 enzyme family. This study analyzed the eff...

journal_title：BioMed research international

authors： Ronquillo-Sánchez MD,Camacho-Carranza R,Fernandez-Mejia C,Hernández-Ojeda S,Elinos-Baez M,Espinosa-Aguirre JJ

更新日期：2013-01-01 00:00:00