Hemodynamic and tubular changes induced by contrast media.

Abstract:

:The incidence of acute kidney injury induced by contrast media (CI-AKI) is the third cause of AKI in hospitalized patients. Contrast media cause relevant alterations both in renal hemodynamics and in renal tubular cell function that lead to CI-AKI. The vasoconstriction of intrarenal vasculature is the main hemodynamic change induced by contrast media; the vasoconstriction is accompanied by a cascade of events leading to ischemia and reduction of glomerular filtration rate. Cytotoxicity of contrast media causes apoptosis of tubular cells with consequent formation of casts and worsening of ischemia. There is an interplay between the negative effects of contrast media on renal hemodynamics and on tubular cell function that leads to activation of renin-angiotensin system and increased production of reactive oxygen species (ROS) within the kidney. Production of ROS intensifies cellular hypoxia through endothelial dysfunction and alteration of mechanisms regulating tubular cells transport. The physiochemical characteristics of contrast media play a critical role in the incidence of CI-AKI. Guidelines suggest the use of either isoosmolar or low-osmolar contrast media rather than high-osmolar contrast media particularly in patients at increased risk of CI-AKI. Older age, presence of atherosclerosis, congestive heart failure, chronic renal disease, nephrotoxic drugs, and diuretics may multiply the risk of CI-AKI.

journal_name

Biomed Res Int

authors

Caiazza A,Russo L,Sabbatini M,Russo D

doi

10.1155/2014/578974

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

578974

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

杂志文章,评审
  • Effect of Direct and Indirect Materials on Stress Distribution in Class II MOD Restorations: A 3D-Finite Element Analysis Study.

    abstract::The aim of this study is to investigate the stress distributions of different restoration options for class II mesio-occluso-distal (MOD) cavities. A class II MOD cavity with proximal box gingival floor 1 mm below cementoenamel junction was designed in a mandibular first molar tooth model. 3D finite-element analysis (...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7435054

    authors: Alp Ş,Gulec Alagoz L,Ulusoy N

    更新日期:2020-12-15 00:00:00

  • Aqueous cytokines as predictors of macular edema in patients with diabetes following uncomplicated phacoemulsification cataract surgery.

    abstract::This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery. Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery. The concentra...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/126984

    authors: Dong N,Xu B,Wang B,Chu L,Tang X

    更新日期:2015-01-01 00:00:00

  • Extremely low frequency magnetic fields induce spermatogenic germ cell apoptosis: possible mechanism.

    abstract::The energy generated by an extremely low frequency electromagnetic field (ELF-EMF) is too weak to directly induce genotoxicity. However, it is reported that an extremely low frequency magnetic field (ELF-MF) is related to DNA strand breakage and apoptosis. The testes that conduct spermatogenesis through a dynamic cell...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/567183

    authors: Lee SK,Park S,Gimm YM,Kim YW

    更新日期:2014-01-01 00:00:00

  • Breast MRI in patients with unilateral bloody and serous-bloody nipple discharge: a comparison with galactography.

    abstract:PURPOSE:Assessing the role of breast MRI compared to galactography in patients with unilateral bloody or serous-bloody nipple discharge. MATERIALS AND METHODS:Retrospective study including 53 unilateral discharge patients who performed galactography and MRI. We evaluated the capability of both techniques in identifyin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/806368

    authors: Manganaro L,D'Ambrosio I,Gigli S,Di Pastena F,Giraldi G,Tardioli S,Framarino M,Porfiri LM,Ballesio L

    更新日期:2015-01-01 00:00:00

  • Peripheral leukocyte apoptosis in patients with Parkinsonism: correlation with clinical characteristics and neuroimaging findings.

    abstract::Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and pre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/635923

    authors: Lin WC,Tsai NW,Huang YC,Cheng KY,Chen HL,Li SH,Kung CT,Su YJ,Lin WM,Chen MH,Chiu TM,Yang IH,Lu CH

    更新日期:2014-01-01 00:00:00

  • Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.

    abstract::Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred mo...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2019/9721781

    authors: Shahidi M,Phillips RA,Chik CL

    更新日期:2019-03-13 00:00:00

  • Changes in the mucus barrier during cisplatin-induced intestinal mucositis in rats.

    abstract:AIM:Gastrointestinal mucositis is a frequent complication of antineoplastic chemotherapy, but the effects of chemotherapy on mucosal defense mechanisms remain poorly understood. We studied the effects of cisplatin on mucin, one of the principal defense factors of the gastrointestinal mucosa, and evaluated the efficacy ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/276186

    authors: Yamamoto H,Ishihara K,Takeda Y,Koizumi W,Ichikawa T

    更新日期:2013-01-01 00:00:00

  • Riluzole stimulates BDNF release from human platelets.

    abstract::Brain-derived neurotrophic factor (BDNF) has several functions in the central nervous system, where it contributes to brain development and its functionality through affecting neuronal survival and activity and also modulating neurotransmitter levels. This neurotrophin is also found in the serum, but its origin and pe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/189307

    authors: Türck P,Frizzo ME

    更新日期:2015-01-01 00:00:00

  • An Artificial Intelligence Model for Predicting 1-Year Survival of Bone Metastases in Non-Small-Cell Lung Cancer Patients Based on XGBoost Algorithm.

    abstract::Non-small-cell lung cancer (NSCLC) patients often develop bone metastases (BM), and the overall survival for these patients is usually perishing. However, a model with high accuracy for predicting the survival of NSCLC with BM is still lacking. Here, we aimed to establish a model based on artificial intelligence for p...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3462363

    authors: Huang Z,Hu C,Chi C,Jiang Z,Tong Y,Zhao C

    更新日期:2020-06-27 00:00:00

  • A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population.

    abstract::Many topical agents are available for treating the acute phase of acne; however, few agents have been proven beneficial during the maintenance phase. Objective. To evaluate the efficacy and safety of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid during the maintenance phase of ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2857812

    authors: Kulthanan K,Trakanwittayarak S,Tuchinda P,Chularojanamontri L,Limphoka P,Varothai S

    更新日期:2020-10-16 00:00:00

  • CEUS helps to rerate small breast tumors of BI-RADS category 3 and category 4.

    abstract:PURPOSE:The primary aim of this study was to explore if classification, whether using the BI-RADS categories based on CEUS or conventional ultrasound, was conducive to the identification of benign and malignant category 3 or 4 small breast lesions. MATERIAL AND METHODS:We evaluated 30 malignant and 77 benign small bre...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/572532

    authors: Zhang JX,Cai LS,Chen L,Dai JL,Song GH

    更新日期:2014-01-01 00:00:00

  • A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic.

    abstract::Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is a complex multifactorial process. Animal models are essential to furthering understanding of the degenerative process and testing pot...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5952165

    authors: Daly C,Ghosh P,Jenkin G,Oehme D,Goldschlager T

    更新日期:2016-01-01 00:00:00

  • A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart.

    abstract::Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries. Actually, only few models of cardiac cache...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/9549036

    authors: Sala V,Gatti S,Gallo S,Medico E,Cantarella D,Cimino J,Ponzetto A,Crepaldi T

    更新日期:2016-01-01 00:00:00

  • Synthesis, characterization, and acute oral toxicity evaluation of pH-sensitive hydrogel based on MPEG, poly(ε-caprolactone), and itaconic acid.

    abstract::A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solv...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/239838

    authors: Tan L,Xu X,Song J,Luo F,Qian Z

    更新日期:2013-01-01 00:00:00

  • Structural comparison, substrate specificity, and inhibitor binding of AGPase small subunit from monocot and dicot: present insight and future potential.

    abstract::ADP-glucose pyrophosphorylase (AGPase) is the first rate limiting enzyme of starch biosynthesis pathway and has been exploited as the target for greater starch yield in several plants. The structure-function analysis and substrate binding specificity of AGPase have provided enormous potential for understanding the rol...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/583606

    authors: Sarma K,Sen P,Barooah M,Choudhury MD,Roychoudhury S,Modi MK

    更新日期:2014-01-01 00:00:00

  • Enhanced oral bioavailability of efavirenz by solid lipid nanoparticles: in vitro drug release and pharmacokinetics studies.

    abstract::Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/363404

    authors: Gaur PK,Mishra S,Bajpai M,Mishra A

    更新日期:2014-01-01 00:00:00

  • Effect of supracervical apposition and spontaneous labour on apoptosis and matrix metalloproteinases in human fetal membranes.

    abstract:BACKGROUND:Apoptosis and matrix metalloproteinase (MMP-9) are capable of hydrolysing components of the extracellular matrix and weakening the fetal membranes which leads to eventual rupture, a key process of human parturition. The aim of this study was to determine the effect of supracervical apposition and spontaneous...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/316146

    authors: Chai M,Walker SP,Riley C,Rice GE,Permezel M,Lappas M

    更新日期:2013-01-01 00:00:00

  • Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity.

    abstract::Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/612352

    authors: Chen X,Yang S,Wang J,Song L,Xing R,Liu S,Yu H,Li P

    更新日期:2015-01-01 00:00:00

  • Effectiveness of Foot Biomechanical Orthoses to Relieve Patients Suffering from Plantar Fasciitis: Is the Reduction of Pain Related to Change in Neural Strategy?

    abstract::Plantar fasciitis is a cause of chronic pain under the heel and bottom of the foot. One of the treatments to reduce pain consists of using plantar orthoses to address specific imbalances during foot placement or gait. The aim of the present study was to determine if reduction of pain with a treatment based on plantar ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/3594150

    authors: Moyne-Bressand S,Dhieux C,Dousset E,Decherchi P

    更新日期:2018-12-12 00:00:00

  • Minimally Invasive Surgical Treatment of Acute Epidural Hematoma: Case Series.

    abstract::Background and Objective. Although minimally invasive surgical treatment of acute epidural hematoma attracts increasing attention, no generalized indications for the surgery have been adopted. This study aimed to evaluate the effects of minimally invasive surgery in acute epidural hematoma with various hematoma volume...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6507350

    authors: Wang W

    更新日期:2016-01-01 00:00:00

  • Blood biomarkers for amyotrophic lateral sclerosis: myth or reality?

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal condition primarily characterized by the selective loss of upper and lower motor neurons. At present, the diagnosis and monitoring of ALS is based on clinical examination, electrophysiological findings, medical history, and exclusion of confounding disorders. There is the...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/525097

    authors: Robelin L,Gonzalez De Aguilar JL

    更新日期:2014-01-01 00:00:00

  • Balance dysfunction in Parkinson's disease.

    abstract::Stability and mobility in functional motor activities depend on a precise regulation of phasic and tonic muscular activity that is carried out automatically, without conscious awareness. The sensorimotor control of posture involves a complex integration of multisensory inputs that results in a final motor adjustment p...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/434683

    authors: Rinalduzzi S,Trompetto C,Marinelli L,Alibardi A,Missori P,Fattapposta F,Pierelli F,Currà A

    更新日期:2015-01-01 00:00:00

  • HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20/TNFAIP3 in NF-κB Signaling.

    abstract::In the past decade, much emphasis has been put on the transcriptional activation of HIV-1, which is proposed as a promised strategy for eradicating latent HIV-1 provirus. Two drugs, prostratin and hexamethylene bisacetamide (HMBA), have shown potent effects as inducers for releasing HIV-1 latency when used alone or in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5173205

    authors: Chen D,Wang H,Aweya JJ,Chen Y,Chen M,Wu X,Chen X,Lu J,Chen R,Liu M

    更新日期:2016-01-01 00:00:00

  • Phylogenetic and in silico functional analyses of thermostable-direct hemolysin and tdh-related encoding genes in Vibrio parahaemolyticus and other Gram-negative bacteria.

    abstract::Emergence and spread of pandemic strains of Vibrio parahaemolyticus have drawn attention to make detailed study on their genomes. The pathogenicity of V. parahaemolyticus has been associated with thermostable-direct hemolysin (TDH) and/or TDH-related hemolysin (TRH). The present study evaluated characteristics of tdh ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/576528

    authors: Bhowmik SK,Pazhani GP,Ramamurthy T

    更新日期:2014-01-01 00:00:00

  • Novel Model to Predict the Prognosis of Patients with Stage II-III Colon Cancer.

    abstract::Different opinions exist on the relationship between the C-reactive protein-to-albumin ratio (CAR) and the prognosis of colon cancer. This study is aimed at evaluating the relationship between CAR and prognosis of stage II-III colon cancer and establishing a clinical prognosis model. Patients were randomised to a trai...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8812974

    authors: Xu Y,Liang F,Chen Y,Wang Z,Zhong H,Tang W

    更新日期:2020-11-22 00:00:00

  • Impact of Infection Dose and Previous Serum Antibodies against the Locus of Enterocyte Effacement Proteins on Escherichia coli O157:H7 Shedding in Calves following Experimental Infection.

    abstract::Escherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome. Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with eithe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/290679

    authors: Martorelli L,Hovde CJ,Vilte DA,Albanese A,Zotta E,Ibarra C,Cantet RJ,Mercado EC,Cataldi A

    更新日期:2015-01-01 00:00:00

  • AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways.

    abstract::The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of AKNA in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, AKNA was found deregulat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6726759

    authors: Wang G,Sun D,Li W,Xin Y

    更新日期:2020-05-13 00:00:00

  • Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience.

    abstract::Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/261813

    authors: Pawlaczyk K,Baum E,Schwermer K,Hoppe K,Lindholm B,Breborowicz A

    更新日期:2015-01-01 00:00:00

  • Antagonistic interactions of "Ya-Sa-Marn-Phlae" ethanol extract in combination with topical antiseptics against clinical isolates of Staphylococcus aureus.

    abstract::This investigation was aimed at assessing a possible interaction of a traditional Thai herbal recipe, "Ya-Sa-Marn-Phlae (YSMP)," used for wound treatments with topical antiseptics, povidone-iodine (PI) solution and hydrogen peroxide (H2O2), and effects of THR-SK010 alone and the combinations on Staphylococcus aureus. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/867603

    authors: Chusri S,Tongrod S,Chokpaisarn J,Limsuwan S,Voravuthikunchai SP

    更新日期:2014-01-01 00:00:00

  • Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats.

    abstract::Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg bod...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/8428304

    authors: Ekanayake CP,Thammitiyagodage MG,Padumadasa S,Seneviratne B,Padumadasa C,Abeysekera AM

    更新日期:2019-12-03 00:00:00