Abstract:
:Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have been intensively investigated. Outcomes of clinical trials suggested several pitfalls in the choice of biomarkers, development of drug candidates, and interaction of drug-targeted molecules; however, they also aroused concerns on the potential deficiency in our understanding of pathogenesis of AD, and ultimately stimulated the advent of novel drug targets tests. The anticipated increase of AD patients in next few decades makes development of better therapy an urgent issue. Here we attempt to summarize and compare putative therapeutic strategies that have completed clinical trials or are currently being tested from various perspectives to provide insights for treatments of Alzheimer's disease.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Jia Q,Deng Y,Qing Hdoi
10.1155/2014/837157subject
Has Abstractpub_date
2014-01-01 00:00:00pages
837157eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章,评审abstract::The interplay between Aspergillus fumigatus and the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors of A. fumigatus are related to the fungus biological characteristics, for example, structu...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/693023
更新日期:2013-01-01 00:00:00
abstract::Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8579619
更新日期:2019-01-20 00:00:00
abstract::Nematodes infections are responsible for debilitating conditions and economic losses in domestic animals as well as livestock and are considered an important public health problem due to the high prevalence in humans. The nematode resistance for drugs has been reported for livestock, highlighting the importance for de...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/879263
更新日期:2015-01-01 00:00:00
abstract::Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2019/5897505
更新日期:2019-07-28 00:00:00
abstract::Background. Surgical correction of mitral regurgitation (MR) can lead to postoperative low cardiac output state. We aimed to assess the acute hemodynamic changes after percutaneous MitraClip therapy (a unique model without influence of factors linked to surgical procedure) in patients with functional MR without the in...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/6296972
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Recovery of walking outdoors after hip fracture is important for equal participation in the community. The causes of poor recovery are not fully understood. This study investigates recovery of walking outdoors and associated determinants after hip fracture. METHODS:A prospective follow-up study, among clinical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/289549
更新日期:2014-01-01 00:00:00
abstract::Trichoderma spp. are important biocontrol filamentous fungi, which are widely used for their adaptability, broad antimicrobial spectrum, and various antagonistic mechanisms. In our previous studies, we cloned thga1 gene encoding GαI protein from Trichoderma harzianum Th-33. Its knockout mutant showed that the growth r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8329513
更新日期:2016-01-01 00:00:00
abstract:Background:Osteonecrosis of the femoral head (ONFH) is a challenge for surgeons and is still without effective treatment method. This study is aimed at evaluating the combined pharmacotherapy with alendronate and desferoxamine for preventing glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) and evaluatin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3120458
更新日期:2020-09-21 00:00:00
abstract::Metastasis is the leading cause of lung cancer-associated death. Downregulated expression of E-cadherin followed by epithelial-mesenchymal transition (EMT) is critical for metastasis initiation in lung cancer. BTBD7 plays essential roles in lung cancer metastasis, but the mechanisms remain unknown. This study aimed to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5937635
更新日期:2019-11-27 00:00:00
abstract::Introduction. Second-line antituberculosis drugs (SLDs) are used for treating multidrug-resistant tuberculosis (MDR-TB). Prolonged delays before confirming MDR-TB with drug susceptibility testing (DST) could result in transmission of drug-resistant strains and inappropriate use of SLDs, thereby increasing the risk of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2628913
更新日期:2016-01-01 00:00:00
abstract:Objective:ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1892458
更新日期:2020-11-27 00:00:00
abstract:Objective:Primary headache and obesity are highly prevalent disorders in the general population. Although many studies have reported an association between the two, there is still no overall comprehension about this relationship. To gain a more accurate understanding in this regard, we analyzed data from a 2011 cross-s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4630490
更新日期:2019-04-15 00:00:00
abstract::Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects. Ten patients with unilater...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6560234
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:This paper presents the final results of a cross-sectional study started in 2010. It compares the perceived efficacy of different types of tobacco health warning (texts versus shocking pictures) to quit or reduce tobacco use. METHODS:The study conducted between 2010 and 2012 in Italy enrolled adults smoke...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/723035
更新日期:2014-01-01 00:00:00
abstract::Oyster mushroom Pleurotus florida was cultivated on different combinations of wheat straw (WS) as basal substrate and oyster shell powder (OSP) supplement. The OSP supplementation considerably responded to different cultivation phases. The mycelium grew fast and showed rapid growth rate (8.91 mmd(-1)) in WS + OSP (97 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/386265
更新日期:2014-01-01 00:00:00
abstract::Autophagic elements typically appear as spherical bodies. During their life they undergo a series of changes (e.g., fusion, degradation of content, and swelling) which influence their size in a way that may be characteristic for cell type, stage of maturation, or various experimentally manipulated parameters. A simple...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/578698
更新日期:2014-01-01 00:00:00
abstract::Pure HA and 1, 3, 5, and 10 vol% multiwalled carbon nanotube- (MWNT-) reinforced hydroxyapatite (HA) were consolidated using a spark plasma sintering (SPS) technique. The relative density of pure HA increased with increasing sintering temperature, but that of the MWNT/HA composite reached almost full density at 900°C,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/768254
更新日期:2014-01-01 00:00:00
abstract::Chromosome/DNA instability could be one of the primary causes of malignant cell transformation. The objective of the present study was to evaluate the spontaneous genetic damages in exfoliated cells of buccal mucosa of head and neck cancer (HNC) by counting micronucleus (MN) and binucleated (BN) cells frequencies. MN ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/905252
更新日期:2013-01-01 00:00:00
abstract::Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries. Actually, only few models of cardiac cache...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9549036
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to compare the effect of PbtO2-guided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 20...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/529580
更新日期:2015-01-01 00:00:00
abstract::Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness amon...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2543262
更新日期:2017-01-01 00:00:00
abstract::WHO reported that adherence among patients with chronic diseases averages only 50% in developed countries. This is recognized as a significant public health issue, since medication nonadherence leads to poor health outcomes and increased healthcare costs. Improving medication adherence is, therefore, crucial and revea...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/217047
更新日期:2015-01-01 00:00:00
abstract::Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1750368
更新日期:2018-02-22 00:00:00
abstract::The purpose of this paper is to examine how well the human induced pluripotent stem cell (hiPSC) colony images can be classified using error-correcting output codes (ECOC). Our image dataset includes hiPSC colony images from three classes (bad, semigood, and good) which makes our classification task a multiclass probl...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3025057
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper. METHODS:Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/857628
更新日期:2015-01-01 00:00:00
abstract::Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/583035
更新日期:2014-01-01 00:00:00
abstract::Sentinel lymph node biopsy (SLNB) emerged in the 1990s as a new technique in the surgical management of the axilla for patients with early breast cancer, resulting in lower complication rates and better quality of life than axillary lymph node dissection (ALND). Today SLNB is firmly established in the armamentarium of...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/405949
更新日期:2015-01-01 00:00:00
abstract::Nitric oxide (NO) has a wide variety of physiological functions in the kidney. Besides the regulatory effects in intrarenal haemodynamics and glomerular microcirculation, in vivo studies reported the diuretic and natriuretic effects of NO. However, opposite results showing the stimulatory effect of NO on Na+ reabsorpt...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/6871081
更新日期:2017-01-01 00:00:00
abstract::Tantalum rod implantation with vascularized iliac grafting has been reported to be an effective method for the treatment of young patients with osteonecrosis of the femoral head (ONFH) to avert the need for total hip arthroplasty (THA). However, there have been unsatisfactory success rates for end-stage ONFH. The auth...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/240506
更新日期:2015-01-01 00:00:00
abstract::Although disorders of the stomatognathic system are common, the mechanisms involved are unknown. Our objective was to study the changes in the masseter muscles after unilateral exodontia. Molar extraction was performed on Wistar rats (left side), and the animals were sacrificed after either 14 or 26 days. The masseter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/563463
更新日期:2014-01-01 00:00:00