The immune interplay between the host and the pathogen in Aspergillus fumigatus lung infection.

Abstract:

:The interplay between Aspergillus fumigatus and the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors of A. fumigatus are related to the fungus biological characteristics, for example, structure, ability to grow and adapt to high temperatures and stress conditions, besides capability of evading the immune system and causing damage to the host. In this context, the fungus recognition by the host innate immunity occurs when the pathogen disrupts the natural and chemical barriers followed by the activation of acquired immunity. It seems clear that a Th1 response has a protective role, whereas Th2 reactions are often associated with higher fungal burden, and Th17 response is still controversial. Furthermore, a fine regulation of the effector immunity is required to avoid excessive tissue damage associated with fungal clearance, and this role could be attributed to regulatory T cells. Finally, in this work we reviewed the aspects involved in the complex interplay between the host immune response and the pathogen virulence factors, highlighting the immunological issues and the importance of its better understanding to the development of novel therapeutic approaches for invasive lung aspergillosis.

journal_name

Biomed Res Int

authors

Sales-Campos H,Tonani L,Cardoso CR,Kress MR

doi

10.1155/2013/693023

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

693023

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

杂志文章,评审
  • Diagnostic and Vaccination Approaches for Newcastle Disease Virus in Poultry: The Current and Emerging Perspectives.

    abstract::Newcastle disease (ND) is one of the most devastating diseases that considerably cripple the global poultry industry. Because of its enormous socioeconomic importance and potential to rapidly spread to naïve birds in the vicinity, ND is included among the list of avian diseases that must be notified to the OIE immedia...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/7278459

    authors: Bello MB,Yusoff K,Ideris A,Hair-Bejo M,Peeters BPH,Omar AR

    更新日期:2018-08-05 00:00:00

  • CYLD Deubiquitinase Negatively Regulates High Glucose-Induced NF-κB Inflammatory Signaling in Mesangial Cells.

    abstract::Nuclear factor-kappa B (NF-κB) is the key part of multiple signal transduction of inflammation in the pathogenesis of diabetic nephropathy (DN). The ubiquitin-proteasome system is extensively involved in the regulation of the NF-κB pathway. Cylindromatosis (CYLD) has deubiquitinase activity and acts as a negative regu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/3982906

    authors: Li Y,Huang W,Xu Y,Zhou L,Liang Y,Gao C,Long Y,Xu Y

    更新日期:2017-01-01 00:00:00

  • Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson's disease?

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder caused by selective loss of dopaminergic neurons in the substantia nigra pars compacta which leads to dysfunction of cerebral pathways critical for the control of movements. The diagnosis of PD is based on motor symptoms, such as bradykinesia, akinesia, muscular...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/519816

    authors: Ciurleo R,Di Lorenzo G,Bramanti P,Marino S

    更新日期:2014-01-01 00:00:00

  • Integrative effects of feeding Aspergillus awamori and fructooligosaccharide on growth performance and digestibility in broilers: promotion muscle protein metabolism.

    abstract::This study was conducted to show the effect of Aspergillus awamori (AA), fructooligosaccharide (FOS), and combined Aspergillus awamori and fructooligosaccharide (AA + FOS) on growth, digestibility, blood parameters, and expression of some growth-related genes. A total of 60 broiler chicks at the age of 15 d were divid...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/946859

    authors: Saleh AA,Amber K,El-Magd MA,Atta MS,Mohammed AA,Ragab MM,Abd El-Kader H

    更新日期:2014-01-01 00:00:00

  • An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease.

    abstract::The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects o...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/4020249

    authors: Pei K,Gui T,Kan D,Feng H,Jin Y,Yang Y,Zhang Q,Du Z,Gai Z,Wu J,Li Y

    更新日期:2020-07-18 00:00:00

  • Yes-Associated Protein 1 as a Novel Prognostic Biomarker for Gastrointestinal Cancer: A Meta-Analysis.

    abstract:Background:Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of Y...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2018/4039173

    authors: Zhang L,Song X,Li X,Wu C,Jiang J

    更新日期:2018-11-14 00:00:00

  • Assessment of Random Error in Phantom Dosimetry with the Use of Error Simulation in Statistical Software.

    abstract:OBJECTIVE:To investigate if software simulation is practical for quantifying random error (RE) in phantom dosimetry. MATERIALS AND METHODS:We applied software error simulation to an existing dosimetry study. The specifications and the measurement values of this study were brought into the software (R version 3.0.2) to...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/596858

    authors: Hoogeveen RC,Martens EP,van der Stelt PF,Berkhout WE

    更新日期:2015-01-01 00:00:00

  • Syringobulbia in Patients with Chiari Malformation Type I: A Systematic Review.

    abstract::This study aimed to summarize the clinical features, diagnosis, and treatment of Chiari malformation type I- (CM-1-) associated syringobulbia. We performed a literature review of CM-1-associated syringobulbia in PubMed, Ovid MEDLINE, and Web of Science databases. Our concerns were the clinical features, radiologic pre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4829102

    authors: Shen J,Shen J,Huang K,Wu Y,Pan J,Zhan R

    更新日期:2019-03-19 00:00:00

  • Serum Osteocalcin and Testosterone Concentrations in Adult Males with or without Primary Osteoporosis: A Meta-Analysis.

    abstract::Osteocalcin (Ocn) and testosterone play important roles in male skeleton. However, the concentrations of serum osteocalcin and testosterone have never been systematically compared between populations with and without primary male osteoporosis, a common skeletal disorder in adult males. We searched the PubMed, Embase, ...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2017/9892048

    authors: Liu ZY,Yang Y,Wen CY,Rong LM

    更新日期:2017-01-01 00:00:00

  • Comparisons of Jaw Line and Face Line after Mandibular Setback: Intraoral Vertical Ramus versus Sagittal Split Ramus Osteotomies.

    abstract:Background:This study investigates the differences in the lateral profile and frontal appearance after sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO) procedures for the correction of mandibular prognathism. Methods:Sixty patients (30 SSRO and 30 IVRO) underwent mandibular setback s...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1375085

    authors: Chen CM,Tseng YC,Ko EC,Chen MY,Chen KJ,Cheng JH

    更新日期:2018-12-18 00:00:00

  • The effect of nicotine dependence on psychopathology in patients with schizophrenia.

    abstract:INTRODUCTION:Our study aims to determine the prevalence of nicotine dependence and investigate the effect of nicotine dependence on psychopathology among schizophrenia patients. METHODS:A cross-sectional study was carried out in an outpatient psychiatric clinic at a general hospital in Malaysia. 180 recruited subjects...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2015/730291

    authors: Yee A,Bt Nek Mohamed NN,Binti Hashim AH,Loh HS,Harbajan Singh MK,Ng CG,Jambunathan ST

    更新日期:2015-01-01 00:00:00

  • Gene profiling of bone around orthodontic mini-implants by RNA-sequencing analysis.

    abstract::This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tiss...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/538080

    authors: Nahm KY,Heo JS,Lee JH,Lee DY,Chung KR,Ahn HW,Kim SH

    更新日期:2015-01-01 00:00:00

  • Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition.

    abstract::Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide. In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note. In the present study, we investigated the impact of the gender on the development of experimental CKD in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2159739

    authors: Fanelli C,Dellê H,Cavaglieri RC,Dominguez WV,Noronha IL

    更新日期:2017-01-01 00:00:00

  • The glycosylation of AGP and its associations with the binding to methadone.

    abstract::Methadone remains the most common form of pharmacological therapy for opioid dependence; however, there is a lack of explanation for the reports of its relatively low success rate in achieving complete abstinence. One hypothesis is that in vivo binding of methadone to the plasma glycoprotein alpha-1-acid glycoprotein ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/108902

    authors: Behan JL,Cruickshank YE,Matthews-Smith G,Bruce M,Smith KD

    更新日期:2013-01-01 00:00:00

  • Hepatitis B Infection and Mother-to-Child Transmission in Haiphong, Vietnam: A Cohort Study with Implications for Interventions.

    abstract:Background:There is little data available on HBV infection and mother-to-child transmission (MTCT) in Vietnam. Objective:This study is aimed at assessing the prevalence of HBV infection and the current situation of MTCT in Haiphong, Vietnam. Methods:A transversal survey of 1721 pregnant women followed by an observati...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4747965

    authors: Khue PM,Thuy Linh NT,Vinh VH,Dung LV,Nguyen Van B

    更新日期:2020-08-20 00:00:00

  • Association Use of Bisphosphonates with Risk of Breast Cancer: A Meta-Analysis.

    abstract:Background:Previous studies have investigated the association between the use of bisphosphonates and the development of breast cancer, which presented controversial results. Thus, this meta-analysis was conducted to summarize the current evidence of the association of bisphosphonate use with breast cancer risk. Method...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/5606573

    authors: Peng R,Liang X,Zhang G,Yao Y,Chen Z,Pan X,Wang J,Liu G

    更新日期:2020-10-06 00:00:00

  • The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study.

    abstract::The incidence of postoperative nausea and vomiting (PONV) is 30-50% after surgery. PONV occurs frequently, especially after craniotomy. In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant, a neurokinin-1 (NK1) receptor antago...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/307025

    authors: Tsutsumi YM,Kakuta N,Soga T,Kume K,Hamaguchi E,Tsutsumi R,Tanaka K

    更新日期:2014-01-01 00:00:00

  • Increased Risk of Coronary Artery Disease in People with a Previous Diagnosis of Carpal Tunnel Syndrome: A Nationwide Retrospective Population-Based Case-Control Study.

    abstract:Background:Existing literature suggests that an association exists between coronary artery disease (CAD) and carpal tunnel syndrome (CTS), but few researchers have explored whether CTS is a risk for CAD. Materials and Methods:This large case-control study explored the association between CTS and CAD, using health insu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3171925

    authors: Chang YC,Chiang JH,Lay IS,Lee YC

    更新日期:2019-03-03 00:00:00

  • Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes.

    abstract::Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during meiotic maturation of mouse oocytes and higher expression of Txndc9 mRNA and protein ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6265890

    authors: Ma F,Hou L,Yang L

    更新日期:2017-01-01 00:00:00

  • Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin.

    abstract::The intra- and extracellular accumulation of misfolded and aggregated amyloid proteins is a common feature in several neurodegenerative diseases, which is thought to play a major role in disease severity and progression. The principal machineries maintaining proteostasis are the ubiquitin proteasomal and lysosomal aut...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/495091

    authors: Maiti P,Manna J,Veleri S,Frautschy S

    更新日期:2014-01-01 00:00:00

  • Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members.

    abstract::Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions. The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns. 63...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/613910

    authors: Zhou T,Yan X,Wang G,Liu H,Gan X,Zhang T,Wang J,Li L

    更新日期:2015-01-01 00:00:00

  • Association of Ki-67 Labelling Index and IL-17A with Pituitary Adenoma.

    abstract::The aim of the present study was to determine if the Ki-67 labelling index reflects invasiveness of pituitary adenoma and to evaluate IL-17A concentration in blood serum of pituitary adenoma patients. The study was conducted in the Hospital of Lithuanian University of Health Sciences. All pituitary adenomas were analy...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7490585

    authors: Glebauskiene B,Liutkeviciene R,Vilkeviciute A,Gudinaviciene I,Rocyte A,Simonaviciute D,Mazetyte R,Kriauciuniene L,Zaliuniene D

    更新日期:2018-05-31 00:00:00

  • Combined High Resistin and EGFR Expression Predicts a Poor Prognosis in Breast Cancer.

    abstract::Elevated levels of resistin and epidermal growth factor receptor (EGFR) facilitate the development of breast cancer, although there are no reports of any correlation between these proteins. This study analyzed 392 human breast cancer tissue specimens and 42 samples of adjacent normal tissue. Rates of positive and stro...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8835398

    authors: Zeng Y,Tang CH,Wang Y,Lu HJ,Huang BF,Wang Q,Shao JK,Jin LL,Wang CQ,Teng LS

    更新日期:2020-11-28 00:00:00

  • Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation.

    abstract:Background:We investigated the potential safety of remimazolam and propofol in malignant hyperthermia- (HM-) susceptible patients using ryanodine receptor 1- (RYR1-) expressing human embryonic kidney- (HEK-) 293 cells. Methods:We compared the enhanced responsiveness of HEK-293 cells expressing wild-type RYR1 with that...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2021/8845129

    authors: Watanabe T,Miyoshi H,Noda Y,Narasaki S,Morio A,Toyota Y,Kimura H,Mukaida K,Yasuda T,Tsutsumi YM

    更新日期:2021-01-04 00:00:00

  • Influence of Acquisition Time on MR Image Quality Estimated with Nonparametric Measures Based on Texture Features.

    abstract::Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3706581

    authors: Obuchowicz R,Piórkowski A,Urbanik A,Strzelecki M

    更新日期:2019-11-20 00:00:00

  • Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension.

    abstract::Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase sub...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4935386

    authors: Gilinsky MA,Polityko YK,Markel AL,Latysheva TV,Samson AO,Polis B,Naumenko SE

    更新日期:2020-02-12 00:00:00

  • A Retrospective Study on the Morphology of Posterior Malleolar Fractures Based on a CT Scan: Whether We Ignore the Importance of Fracture Height.

    abstract:Objective:The aim of this study was to investigate the respective correlation between the height (H) of a posterior malleolar fracture (PMF) and the involved area (S) of an articular surface and the presence of "die-punch." Methods:Patients with closed posterior malleolar fractures admitted to our hospital from Januar...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2903537

    authors: Wang Z,Yuan C,Zhu G,Geng X,Zhang C,Huang J,Ma X,Wang X

    更新日期:2020-07-29 00:00:00

  • Association between the Non-high-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio and the Risk of Coronary Artery Disease.

    abstract:Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7146028

    authors: You J,Wang Z,Lu G,Chen Z

    更新日期:2020-03-07 00:00:00

  • The c-MYC protooncogene expression in cholesteatoma.

    abstract::Cholesteatoma is an epidermoid cyst, which is most frequently found in the middle ear. The matrix of cholesteatoma is histologically similar to the matrix of the epidermoid cyst of the skin (atheroma); their epithelium is characterized by hyperproliferation. The c-MYC protooncogene located on chromosome 8q24 encodes a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/639896

    authors: Palkó E,Póliska S,Csákányi Z,Katona G,Karosi T,Helfferich F,Penyige A,Sziklai I

    更新日期:2014-01-01 00:00:00

  • Clinical Usefulness of Immunohistochemical Staining of p57 kip2 for the Differential Diagnosis of Complete Mole.

    abstract:OBJECTIVE:Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? METHODS AND MATERIALS:Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and exami...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/905648

    authors: Sasaki S,Sasaki Y,Kunimura T,Sekizawa A,Kojima Y,Iino K

    更新日期:2015-01-01 00:00:00