Abstract:
:Osteocalcin (Ocn) and testosterone play important roles in male skeleton. However, the concentrations of serum osteocalcin and testosterone have never been systematically compared between populations with and without primary male osteoporosis, a common skeletal disorder in adult males. We searched the PubMed, Embase, and Cochrane Library for relevant studies. A meta-analysis was performed to compare the serum osteocalcin and testosterone concentrations between primary osteoporotic males and age-matched nonosteoporotic (non-OP) males. Five case-control studies with 300 adult males were included. We found no significant difference between cases and controls in serum total osteocalcin (TOcn) [95% confidence interval (CI): -1.25, 1.31; p = 0.96] and total testosterone (TT) concentrations [95% CI: -0.88, 4.22; p = 0.20]. The level of evidence of this carefully performed meta-analysis is 3a according to Oxford (UK) CEBM Levels of Evidence. Future well-designed studies with larger sample size and better standardization of Ocn assay are awaited to confirm and update our current findings.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Liu ZY,Yang Y,Wen CY,Rong LMdoi
10.1155/2017/9892048subject
Has Abstractpub_date
2017-01-01 00:00:00pages
9892048eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章,meta分析abstract::Aims. We describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify and compare simultaneously global methylation and hydroxymethylation in human DNA of different tissues. Materials and Methods. Blood and saliva DNA from fourteen volunteers was processed for epigenetic endpoints using LC-M...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/845041
更新日期:2015-01-01 00:00:00
abstract::Cardiac computed tomography angiography (CCTA) is widely used as a diagnostic tool for evaluation of coronary artery disease (CAD). Despite the excellent capability to rule-out CAD, CCTA may overestimate the degree of stenosis; furthermore, CCTA analysis can be time consuming, often requiring advanced postprocessing t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6649410
更新日期:2020-12-16 00:00:00
abstract::The most expedient unit of the human body is its cell. Encapsulated within the cell are many infinitesimal entities and molecules which are protected by a cell membrane. The proteins that are associated with this lipid based bilayer cell membrane are known as membrane proteins and are considered to play a significant ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8370132
更新日期:2016-01-01 00:00:00
abstract::Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/7874109
更新日期:2020-03-03 00:00:00
abstract::Nonlinear contrast-enhanced ultrasound imaging schemes strive to suppress tissue signals in order to better visualize nonlinear signals from blood-pooling ultrasound contrast agents. Because tissue does not generate a subharmonic response (i.e., signal at half the transmit frequency), subharmonic imaging has been prop...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/640397
更新日期:2015-01-01 00:00:00
abstract:Background:The aim of our study was to investigate the impact of abdominal wall reconstruction surgery on tissue anatomy and to explore how flap surgery influences the patient's immune status. Methods:Experimental abdominal wall defects were created in 8 Sus scrofa (swine) animal models. The animals were divided into ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2421585
更新日期:2017-01-01 00:00:00
abstract::Studies pertaining to trans fatty acids (TFA), which have been implicated in development of chronic diseases, are more relevant in developing countries where nutrition transition is changing traditional habits and practices. Measuring TFA is an arduous task because of the need for fat biopsies. This study identifies a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276174
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/8094152.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2017/3689716
更新日期:2017-01-01 00:00:00
abstract:Objective:The aim of this study is to compare the clinical outcomes of two-level percutaneous endoscopic lumbar discectomy (PELD) and foraminoplasty PELD in treating highly migrated lumbar disc herniations. Methods:Patients with highly migrated lumbar disc herniations were enrolled from May 2014 to June 2016. Low back...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9681424
更新日期:2019-10-13 00:00:00
abstract:Introduction:The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6038106
更新日期:2018-01-02 00:00:00
abstract:Background and Aim:The incidence of nonalcoholic fatty liver disease (NAFLD) as a metabolic disease is increasing annually. In the present study, we aimed to explore the influence of NAFLD on the severity of acute pancreatitis (AP). Methods:The severity of AP was diagnosed and analyzed according to the 2012 revised At...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9583790
更新日期:2019-01-22 00:00:00
abstract:INTRODUCTION:Spectroscopic analysis of urine samples from laboratory animals can be used to predict the efficacy and side effects of drugs. This employs methods combining (1)H NMR spectroscopy with quantification of biomarkers or with multivariate data analysis. The most critical steps in data evaluation are analytical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/878374
更新日期:2013-01-01 00:00:00
abstract:Objective:The exact shape of the dose-response relationship between maternal body mass index (BMI) and the risk of congenital heart defects (CHDs) in infants has not been clearly defined yet. This study aims to further clarify the relationship between maternal obesity and the risk of CHDs in infants by an overall and d...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/1315796
更新日期:2019-07-07 00:00:00
abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1843142
更新日期:2018-02-06 00:00:00
abstract:Aims:To evaluate the effectiveness and safety of peritoneal dialysis (PD) in treating refractory congestive heart failure (RCHF) with cardiorenal syndrome (CRS). Methods:A total of 36 patients with RCHF were divided into type 2 CRS group (group A) and non-type 2 CRS group (group B) according to the patients' clinical ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/6529283
更新日期:2018-05-17 00:00:00
abstract::The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the gene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/621034
更新日期:2015-01-01 00:00:00
abstract:Background:Influenza virus mainly causes acute respiratory infections in humans. However, the diagnosis of influenza is not accurate based on clinical evidence, as the symptoms of flu are similar to other respiratory virus. The lateral-flow assay is a rapid method to detect influenza virus. But the effectiveness of the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3969868
更新日期:2020-09-08 00:00:00
abstract::Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4-7 days old) is advantageously thinner and is considered as an alternative to that from adult animals. Here, the structures of adult and neonatal bovine pericardiu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/189197
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Noncardiac chest pain (NCCP) is seen more frequently in young population and in these patients loss of function is evolving in social and professional areas. The aim of the study is to evaluate the levels of anxiety and somatic perception in patients with chest pain presenting to cardiology clinic. METHODS:F...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/896183
更新日期:2014-01-01 00:00:00
abstract::Subarachnoid hemorrhage (SAH) is a devastating neurological disorder. Patients with aneurysmal SAH develop secondary complications that are important causes of morbidity and mortality. Aside from secondary neurological injuries, SAH has been associated with nonneurologic medical complications, such as neurocardiogenic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/858496
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2020/9175369
更新日期:2020-09-07 00:00:00
abstract::A series of halo-substituted mixed ester/amide-based analogues 4a-l have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8867407
更新日期:2020-12-24 00:00:00
abstract::We have evaluated the cloning and functional expression of previously described broad antimicrobial spectrum bacteriocins SRCAM 602, OR-7, E-760, and L-1077, by recombinant Pichia pastoris. Synthetic genes, matching the codon usage of P. pastoris, were designed from the known mature amino acid sequence of these bacter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/767183
更新日期:2015-01-01 00:00:00
abstract:Results:The VMAT plans showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, monitor units (MUs), and maximum dose (Dmax) to the contralateral breast compared with TSP and 9FIMRT plans. The TSP provided better protection for Dmean of the heart and left ventricle ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2020/7131590
更新日期:2020-03-26 00:00:00
abstract:OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/356427
更新日期:2014-01-01 00:00:00
abstract::The differential effects of a selective kappa- (κ-) opioid receptor agonist, U50488, were elucidated by monitoring the contraction of isolated guinea pig atrial and ventricular muscles. In electrically driven left atria, U50488 in nanomolar concentration range decreased the contractile force. Norbinaltorphimine (norBN...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906039
更新日期:2015-01-01 00:00:00
abstract::Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/901941
更新日期:2014-01-01 00:00:00
abstract::This study investigated the effect of cilostazol on proangiogenesis functions in human early endothelial progenitor cells (EPCs) in vitro and the therapeutic implication of hybrid therapy with cilostazol and human early EPCs in vivo. Cilostazol significantly increased colony-forming units and enhanced differentiation ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3639868
更新日期:2016-01-01 00:00:00
abstract::Lycium barbarum is a famous plant in the traditional Chinese medicine. The plant is known to have health-promoting bioactive components. The properties of Lycium barbarum berries cultivated in Umbria (Italy) and their effect on human hepatocellular carcinoma cells (HepG2) have been investigated in this work. The obtai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7529521
更新日期:2016-01-01 00:00:00
abstract::Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6956794
更新日期:2017-01-01 00:00:00