Abstract:
:Introduction. Second-line antituberculosis drugs (SLDs) are used for treating multidrug-resistant tuberculosis (MDR-TB). Prolonged delays before confirming MDR-TB with drug susceptibility testing (DST) could result in transmission of drug-resistant strains and inappropriate use of SLDs, thereby increasing the risk of resistance to SLDs. This study investigated the diagnostic delay in DST and prevalence of baseline SLD resistance in Shanghai and described the distribution of SLD resistance with varied delays to DST. Methods. All registered patients from 2011 to 2013 in Shanghai were enrolled. Susceptibility to ofloxacin, amikacin, kanamycin, and capreomycin was tested. Total delay in DST completion was measured from the onset of symptoms to reporting DST results. Results. Resistance to SLDs was tested in 217 of the 276 MDR-TB strains, with 118 (54.4%) being resistant to at least one of the four SLDs. The median total delay in DST was 136 days. Patients with delay longer than median days were roughly twice more likely to have resistance to at least one SLD (OR 2.22, 95% CI 1.19-4.11). Conclusions. During prolonged delay in DST, primary and acquired resistance to SLDs might occur more frequently. Rapid diagnosis of MDR-TB, improved nosocomial infection controls, and regulated treatment are imperative to prevent SLD resistance.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chen Y,Yuan Z,Shen X,Wu J,Wu Z,Xu Bdoi
10.1155/2016/2628913subject
Has Abstractpub_date
2016-01-01 00:00:00pages
2628913eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章abstract::The aim of this study is to assess the change in intraocular pressure after a road trip, in eyes with different levels of filling with gas tamponade. Five rabbit eyes were subject to pars plana vitrectomy and gas tamponade (filling percentage: 25%, 50%, and 100% of nonexpansile SF6, 100% saline solution, and 100% room...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7326160
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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doi:10.1155/2019/3951574
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
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journal_title:BioMed research international
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journal_title:BioMed research international
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4079849
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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pub_type: 杂志文章,收录出版,评审
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2019-06-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2020-06-07 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/539805
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/9620870
更新日期:2017-01-01 00:00:00