Abstract:
:High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm, and extracellular space. It is an important DAMP molecule that allows communication between damaged or tumor cells and the immune system. Tumor cells exploit HMGB1's ability to activate intracellular pathways that lead to cell growth and migration. Papillary thyroid cancer is a well-differentiated tumor and is often used to study relationships between cells and the inflammatory microenvironment as the latter is characterized by high levels of inflammatory cells and cytokines. Anaplastic thyroid cancer is one of the most lethal human cancers in which many microRNAs and tumor suppressor genes are deregulated. Upregulation of microRNAs 221 and 222 has been shown to induce the malignant phenotype in many human cancers via inhibition of PTEN expression. In this study we suggest that extracellular HMGB1 interaction with RAGE enhances expression of oncogenic cluster miR221/222 that in turn inhibits tumor suppressor gene PTEN in two cell lines derived from human thyroid anaplastic and papillary cancers. The newly identified pathway HMGB1/RAGE/miR221/222 may represent an effective way of tumor escape from immune surveillance that could be used to develop new therapeutic strategies against anaplastic tumors.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Mardente S,Mari E,Massimi I,Fico F,Faggioni A,Pulcinelli F,Antonaci A,Zicari Adoi
10.1155/2015/512027subject
Has Abstractpub_date
2015-01-01 00:00:00pages
512027eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/739010
更新日期:2013-01-01 00:00:00
abstract:Objective:To analyze the ten-year surgical outcomes and postoperative complications of French-Door laminoplasty (FDL) in the management of multilevel cervical spondylotic myelopathy (MCSM) and analyze the prognostic factors for FDL in treating MCSM. Methods:64 patients with MCSM, who were operated by FDL, were include...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3627071
更新日期:2020-05-06 00:00:00
abstract::The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6492183
更新日期:2016-01-01 00:00:00
abstract::Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/690529
更新日期:2014-01-01 00:00:00
abstract:Objective:The aim of this study is to explore the potential pathogenesis of juvenile dermatomyositis by bioinformatics analysis of gene chips, which would screen the hub genes, identify potential biomarkers, and reveal the development mechanism of juvenile dermatomyositis. Material and Methods:We retrieved juvenile de...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7814287
更新日期:2019-12-07 00:00:00
abstract::Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/341308
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Tuberculosis is still one of the most important health problems in developing countries and increasing drug resistance is the main concern for its treatment. This study was designed to characterize the drug resistant Mycobacterium tuberculosis isolated from patients suffering from pulmonary tuberculosis in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/747085
更新日期:2015-01-01 00:00:00
abstract::Little is known about the clinical value of the Hadlock and INTERGROWTH-21st EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7698038
更新日期:2019-01-09 00:00:00
abstract:OBJECTIVE:Cerebral white matter hyperintensity (WMH) with magnetic resonance imaging (MRI) has a potential for predicting cognitive impairment. Serum polyunsaturated fatty acid (PUFA) levels are important for evaluating the extent of atherosclerosis. We investigated whether abnormal PUFA levels affected WMH grading and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/153437
更新日期:2015-01-01 00:00:00
abstract::This study was designed to assess in vitro metacyclogenesis of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis clinical field isolates obtained from patient lesions (L. braziliensis IMG3 and PPS6m; L. amazonensis MAB6). Metacyclogenesis was evaluated by different criteria, namely, promastigot...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/393049
更新日期:2015-01-01 00:00:00
abstract::Purpose. Kawasaki disease (KD) is a systemic vasculitis and is a leading cause of coronary artery lesions (CALs) in childhood. Our previous study has shown higher levels of serum Resistin in KD patients with coronary aneurysm. This study aimed at examining the association of Resistin with inflammatory cytokine express...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3296437
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to investigate the efficacy of the sequential combined 585 nm PDL and the 1064 nm neodymium:yttrium-aluminium-garnet laser (PDL/Nd:YAG) in the treatment of surgical scars and to evaluate the short-term effects by in vivo confocal microscopy (RCM) and the long-term effects by clinical assessme...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/204532
更新日期:2014-01-01 00:00:00
abstract::Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg bod...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8428304
更新日期:2019-12-03 00:00:00
abstract::The goal of the present study were (1) to investigate the pathological characteristics of gastrocnemius muscle (GM) and quantitatively assess GM tissue stiffness in rat models with spinal cord injury (SCI) and (2) to explore the correlation between pathological characteristics changes and Young's modulus value of GM. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5387948
更新日期:2017-01-01 00:00:00
abstract::Graphene is the first 2-dimensional material and possesses a plethora of original properties. Graphene and its derivatives have exhibited a great potential in a number of fields, both medical and nonmedical. The aim of this review is to set the theoretical basis for further research in developing graphene-based endova...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3180954
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/5760612.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/7108272
更新日期:2018-01-08 00:00:00
abstract::Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/421746
更新日期:2015-01-01 00:00:00
abstract::To identify novel susceptibility genes and gene sets for obesity, we conducted a genomewide expression association analysis of obesity via integrating genomewide association study (GWAS) and expression quantitative trait loci (eQTLs) data. GWAS summary data of body mass index (BMI) and waist-to-hip ratio (WHR) was dri...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/3848560
更新日期:2018-05-08 00:00:00
abstract::Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with bai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5201790
更新日期:2019-04-04 00:00:00
abstract:Background:Thyroid cancer is the most common endocrine malignancy, with a recent global increase of 20% in age-related incidence. Ultrasonography and ultrasonography-guided fine-needle aspiration biopsy (FNAB) are the most widely used diagnostic tests for thyroid nodules; however, it is estimated that up to 25% of thyr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/6752141
更新日期:2021-01-12 00:00:00
abstract:PURPOSE:To investigate whether P. acnes could induce disc degeneration and Modic changes when inoculated into the discs of rabbits. METHOD:A wild-type strain of P. acnes isolated from a patient associated with Modic change and disc degeneration was inoculated into the intervertebral discs of rabbits. Meanwhile, S. aur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9612437
更新日期:2016-01-01 00:00:00
abstract::Recent reports of retinal stem cells being present in several locations of the adult eye have sparked great hopes that they may be used to treat the millions of people worldwide who suffer from blindness as a result of retinal disease or injury. A population of proliferative cells derived from the ciliary body epithel...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/531579
更新日期:2013-01-01 00:00:00
abstract::Exposure to a variety of environmental factors such as salinity, drought, metal toxicity, extreme temperature, air pollutants, ultraviolet-B (UV-B) radiation, pesticides, and pathogen infection leads to subject oxidative stress in plants, which in turn affects multiple biological processes via reactive oxygen species ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9732325
更新日期:2019-05-08 00:00:00
abstract::This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tiss...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/538080
更新日期:2015-01-01 00:00:00
abstract::Epidemiological studies have proven an association between consumption of polyphenols and prevention of Alzheimer's disease, the most common form of dementia characterized by extracellular deposition of amyloid beta plaques. The aim of this study is pharmacological screening of the aqueous alcohol extract of Markhamia...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/843263
更新日期:2014-01-01 00:00:00
abstract:Aims:To investigate demographics and socioeconomic status in patients with ulnar nerve compression and the influence of socioeconomic factors on patient-reported outcome measurements (PROM) as evaluated by QuickDASH (short version of Disabilities of Arm, Shoulder and Hand) after surgery for ulnar nerve compression at t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5928649
更新日期:2020-12-18 00:00:00
abstract:Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6762029
更新日期:2020-09-23 00:00:00
abstract::Traumatic brain injury (TBI) represents a significant public health concern and has been associated with high rates of morbidity and mortality. Although several research groups have proposed the use of repetitive transcranial magnetic stimulation (rTMS) to enhance neuroprotection and recovery in patients with TBI, few...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4540291
更新日期:2017-01-01 00:00:00
abstract::In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/814984
更新日期:2014-01-01 00:00:00
abstract::Cardiovascular diseases (CVDs) are considered to be the predominant cause of death in the world. Chinese herb medicines (CHMs) have been widely used for the treatment of CVDs in Asian countries for thousands of years. One reason of high efficacy of CHMs in treating CVDs is attributed to their inhibition in atheroscler...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/5392375
更新日期:2018-06-13 00:00:00