Abstract:
:We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P<0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wang L,Li M,Huang Z,Wang Zdoi
10.1155/2014/419805subject
Has Abstractpub_date
2014-01-01 00:00:00pages
419805eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/143504
更新日期:2015-01-01 00:00:00
abstract:Objective:The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. Methods:Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retina...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2721578
更新日期:2019-04-24 00:00:00
abstract::Severe stages of acute, colonic diverticulitis can progress into intestinal perforations with peritonitis. In such cases, urgent treatment is needed, and Hartmann's procedure is the standard treatment for cases with fecal peritonitis. Peritoneal lavage may be an alternative to resection for acute diverticulitis with p...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/380607
更新日期:2014-01-01 00:00:00
abstract::The effect of crocetin (C20H24O4) on methylcholanthrene- (MCA-) induced uterine cervical cancer in mice was studied in this paper. After the mice were treated orally with crocetin, maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were examined by ELISA...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/829513
更新日期:2015-01-01 00:00:00
abstract::Molecular recognition elements (MREs) can be short sequences of single-stranded DNA, RNA, small peptides, or antibody fragments. They can bind to user-defined targets with high affinity and specificity. There has been an increasing interest in the identification and application of nucleic acid molecular recognition el...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/419318
更新日期:2015-01-01 00:00:00
abstract::This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6915789
更新日期:2016-01-01 00:00:00
abstract::Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8798546
更新日期:2017-01-01 00:00:00
abstract:Objective:The current study aimed to investigate the effects of body position on the level and severity of stuttering in young adults with developmental stuttering. Methods:A total of 24 subjects (male: 17; female: 7; mean age: 24.9 ± 6.2 years) with developmental stuttering participated. The participants were asked t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1817906
更新日期:2019-08-05 00:00:00
abstract::Background. Surgical treatment of proximal humeral fractures (PHF) in osteoporotic bone of elderly patients is challenging. The aim of this retrospective study was to evaluate the clinical and radiological outcome after percutaneous reduction and internal fixation of osteoporotic PHF in geriatric patients using the se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6451849
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. MATERIALS AND METHODS:A comparison of the outcomes of randomized controlled trials (RCTs) included ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7538604
更新日期:2017-01-01 00:00:00
abstract::Actin is one of the most highly conserved proteins and plays crucial roles in many vital cellular functions. In most eukaryotes, it is encoded by a multigene family. Although the actin gene family has been studied a lot, few investigators focus on the comparison of actin gene family in relative species. Here, the purp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/630803
更新日期:2013-01-01 00:00:00
abstract::Rauwolfia tetraphylla L. is an important medicinal plant species which is well known for its pharmaceutically important alkaloids. In the present study, we are reporting about its conservation by in vitro clonal multiplication through the standardized protocol of indirect regeneration by using leaf and stem based call...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3698742
更新日期:2019-04-11 00:00:00
abstract::Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness amon...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2543262
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC). METHODS:Functional reannotation for the human lncRNA was carried out by ncFANs. Real-time quantitative PCR was used to v...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/405860
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Delayed union and nonunion are common complications in atypical femoral fractures (AFFs) despite having good fracture fixation. Demineralized bone matrix (DBM) is a successfully proven method for enhancing fracture healing of the long bone fracture and nonunion and should be used in AFFs. This study aimed to...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/4061539
更新日期:2016-01-01 00:00:00
abstract::Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2686340
更新日期:2019-02-20 00:00:00
abstract:UNLABELLED:The aims of this study were first to clearly define two different entities: locoregional recurrences and limited metastatic disease and secondly to evaluate the place of extensive surgery in these two types of recurrence. MATERIAL AND METHODS:Twenty-four patients were followed from June 2004 until May 2014....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/782654
更新日期:2015-01-01 00:00:00
abstract::Cardiovascular disease (CVD) is the most common cause of death in the world. Recent studies have shown an association between adrenal insufficiency (AI) and increased cardiovascular risk (CVR). Patients with AI receive glucocorticoid (GC) replacement therapy which can lead to varying levels of blood cortisol. It was s...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3691913
更新日期:2017-01-01 00:00:00
abstract::Aerobic granulation of activated sludge was successfully achieved in a full-scale sequencing batch reactor (SBR) with 50,000 m(3) d(-1) for treating a town's wastewater. After operation for 337 days, in this full-scale SBR, aerobic granules with an average SVI30 of 47.1 mL g(-1), diameter of 0.5 mm, and settling veloc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/268789
更新日期:2014-01-01 00:00:00
abstract::It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a tar...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/736104
更新日期:2015-01-01 00:00:00
abstract:Objectives:Patients with stage 3 medication-related osteonecrosis of the jaw (MRONJ) suffer from severe complications. Chemotherapeutic agents and targeted drugs are considered to be associated with the development of MRONJ. However, little is known regarding the association of those agents with stage 3 MRONJ. The purp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5847429
更新日期:2020-10-15 00:00:00
abstract::Effect of Zataria multiflora on bacterial vaginosis and Trichomonas vaginalis is shown in vivo and in vitro. We compare the effectiveness of Zataria multiflora cream and oral metronidazole pill on results of treatment for vaginal infections including Trichomonas and bacterial vaginosis; these infections occur simultan...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/683640
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to investigate the influence of a topically administered hygienic preparation containing a 3% ethanolic extract of Brazilian green propolis (EEP-B) on oral microflora spectrum changes in a group of patients who underwent common oral surgery procedures. Two gel samples were compared: the teste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/869575
更新日期:2015-01-01 00:00:00
abstract::The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5280514
更新日期:2019-03-28 00:00:00
abstract::To explore the antitumor effect of hypoxia-inducible factor-1α short hairpin RNA (HIF-1α shRNA) delivered by ultrasound targeted microbubble destruction (UTMD) and transcatheter arterial embolization (TAE) on rats with hepatic cancer. After the models of transplantation hepatoma were established, Wistar rats were rand...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1937460
更新日期:2019-02-19 00:00:00
abstract::Butyrate produced by the intestinal microbiota is essential for proper functioning of the intestinal immune system. Total dependence on parenteral nutrition (PN) is associated with numerous adverse effects, including severe microbial dysbiosis and loss of important butyrate producers. We hypothesised that a lack of bu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7084734
更新日期:2019-02-28 00:00:00
abstract::Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects of emodin against SAP with SIRS. However, the exact mechanism unde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1736024
更新日期:2016-01-01 00:00:00
abstract::Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life. Both prosurvival and proapoptotic roles have been proposed for HSP60, and HSP60 is reportedly involved in the initiation ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/539805
更新日期:2015-01-01 00:00:00
abstract::Three bioactive fractions, extracellular laccase (ex-LAC), crude endopolysaccharides (c-EPL), and a low molecular subfraction of secondary metabolites (ex-LMS), were isolated from the idiophasic cultures of the white rot fungus Cerrena unicolor. For the first time, we determined the antioxidant properties of these sam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/497492
更新日期:2013-01-01 00:00:00
abstract:Background:Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be relate...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/5190587
更新日期:2020-05-20 00:00:00