Abstract:
:Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life. Both prosurvival and proapoptotic roles have been proposed for HSP60, and HSP60 is reportedly involved in the initiation of autoimmune, metabolic, and cardiovascular diseases. The role of HSP60 in pathogenesis of these diseases remains unclear, partly because of the lack of mouse models expressing HSP60. In this study we generated HSP60 conditional transgenic mice suitable for investigating in vivo outcomes by expressing HSP60 at the targeted organ in disease models. Ubiquitous HSP60 induction in the embryonic stage caused neonatal death in mice at postnatal day 1. A high incidence of atrial septal defects was observed in HSP60-expressing mice, with increased apoptosis and myocyte degeneration that possibly contributed to massive hemorrhage and sponge-like cardiac muscles. Our results showed that neonatal heart failure through HSP60 induction likely involves developmental defects and excessive apoptosis. The conditional HSP60 mouse model is useful for studying crucial biological questions concerning HSP60.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chen TH,Liu SW,Chen MR,Cho KH,Chen TY,Chu PH,Kao YY,Hsu CH,Lin KMdoi
10.1155/2015/539805subject
Has Abstractpub_date
2015-01-01 00:00:00pages
539805eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Objective. This study aims to extract motor ingredients through data mining from wearable sensors in a virtual reality goal-directed shoulder rehabilitation (GDSR) system and to examine their effects toward clinical assessment. Design. A single-group before/after comparison. Setting. Outpatient research hospital. Subj...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7075464
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/849080
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9204708
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/870930
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2351037
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/905648
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3504727
更新日期:2018-08-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8182416
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3178014
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/390789
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7127869
更新日期:2019-03-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8465971
更新日期:2020-02-25 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123601
更新日期:2020-09-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/984041
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8826456
更新日期:2020-12-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2019/8345309
更新日期:2019-03-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/5953036
更新日期:2019-12-04 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4845360
更新日期:2020-11-17 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/635745
更新日期:2015-01-01 00:00:00
abstract:Background:The apolipoprotein E knockout (ApoE -/-) mouse model is well established for the study of terpenoids in the prevention of atherosclerosis. Studies investigating the clinical benefit of terpenoids in humans are scarce. This systematic review and meta-analysis evaluated the effects of terpenoid administration ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2019/2931831
更新日期:2019-07-17 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/853602
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2327034
更新日期:2020-07-24 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/714580
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2920804
更新日期:2020-02-27 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/746192
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/402475
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6820975
更新日期:2018-01-04 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7856517
更新日期:2018-12-09 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/2580969
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/910812
更新日期:2014-01-01 00:00:00