Abstract:
:Hosts' innate defense systems are upregulated by antimicrobial peptide elicitors (APEs). Our aim was to investigate the effects of hyperthermia, ultraviolet A rays (UVA), and ultraviolet C rays (UVC) as well as glucose and ascorbic acid (AA) on the regulation of human β-defensin 1 (DEFB1), cathelicidin (CAMP), and interferon-γ (IFNG) genes in normal human keratinocytes (NHK). The indirect in vitro antimicrobial activity against Staphylococcus aureus and Listeria monocytogenes of these potential APEs was tested. We found that AA is a more potent APE for DEFB1 than glucose in NHK. Glucose but not AA is an APE for CAMP. Mild hypo- (35°C) and hyperthermia (39°C) are not APEs in NHK. AA-dependent DEFB1 upregulation below 20 mM predicts in vitro antimicrobial activity as well as glucose- and AA-dependent CAMP and IFNG upregulation. UVC upregulates CAMP and DEFB1 genes but UVA only upregulates the DEFB1 gene. UVC is a previously unrecognized APE in human cells. Our results suggest that glucose upregulates CAMP in an IFN-γ-independent manner. AA is an elicitor of innate immunity that will challenge the current concept of late activation of adaptive immunity of this vitamin. These results could be useful in designing new potential drugs and devices to combat skin infections.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cruz Díaz LA,Flores Miramontes MG,Chávez Hurtado P,Allen K,Gonzalez Ávila M,Prado Montes de Oca Edoi
10.1155/2015/714580subject
Has Abstractpub_date
2015-01-01 00:00:00pages
714580eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract:Objective:Neuroimaging studies revealed the functional reorganization or the structural changes during stroke recovery. However, previous studies did not combine the functional and structural information and the results might be affected by heterogeneous lesion. This study aimed to investigate functional activation-inf...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4345205
更新日期:2017-01-01 00:00:00
abstract::Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2381482
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to compare the prevalence of different virulence factor (VF) genes in extended-spectrum beta-lactamase (ESBL) producing Escherichia coli strains isolated from the Baltic Sea region. A total of 432 strains of phenotypically ESBL positive E. coli were collected from 20 institutions located in E...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/427254
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/7865747.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/6348625
更新日期:2018-05-14 00:00:00
abstract::Praeruptorins belonging to the angular-type pyranocoumarins are bioactive constituents that have been isolated from some Peucedanum species such as P. praeruptorum, which is used in traditional Chinese medicine for treatment of cold, cough, upper respiratory infections, and so forth. Many reports have demonstrated tha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/343808
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Noncardiac chest pain (NCCP) is seen more frequently in young population and in these patients loss of function is evolving in social and professional areas. The aim of the study is to evaluate the levels of anxiety and somatic perception in patients with chest pain presenting to cardiology clinic. METHODS:F...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/896183
更新日期:2014-01-01 00:00:00
abstract::Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4-7 days old) is advantageously thinner and is considered as an alternative to that from adult animals. Here, the structures of adult and neonatal bovine pericardiu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/189197
更新日期:2014-01-01 00:00:00
abstract::Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries. Actually, only few models of cardiac cache...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9549036
更新日期:2016-01-01 00:00:00
abstract:Background:The pathogenesis of abdominal aortic aneurysm (AAA) is characterized by atherosclerosis with chronic inflammation in the aortic wall. Montelukast is a selective cys-LT 1 receptor antagonist that can suppress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9104680
更新日期:2019-05-27 00:00:00
abstract::The aim of the study was to assess the prevalence of temporomandibular disorders (TMD) and oral parafunctions, as well as their correlation with psychoemotional factors in Polish university students. The research was conducted in a group of 456 students (N = 456). The examination form comprised of two parts: survey an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/472346
更新日期:2014-01-01 00:00:00
abstract::Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function. This imbalance coincided with retinal ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/571456
更新日期:2015-01-01 00:00:00
abstract:Objective:The aim of this study is to compare the clinical outcomes of two-level percutaneous endoscopic lumbar discectomy (PELD) and foraminoplasty PELD in treating highly migrated lumbar disc herniations. Methods:Patients with highly migrated lumbar disc herniations were enrolled from May 2014 to June 2016. Low back...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9681424
更新日期:2019-10-13 00:00:00
abstract::Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions. The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns. 63...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/613910
更新日期:2015-01-01 00:00:00
abstract::Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/839761
更新日期:2013-01-01 00:00:00
abstract::The quantitative and reproducible analysis of the standard body movement in Tai Chi Chuan (TCC) was performed in this study. We aimed to provide a reference of the upper extremities for standardizing TCC practice. Microsoft Kinect was used to record the motion during the practice of TCC. The preparation form and eight...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2538765
更新日期:2018-01-29 00:00:00
abstract:Results:The VMAT plans showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, monitor units (MUs), and maximum dose (Dmax) to the contralateral breast compared with TSP and 9FIMRT plans. The TSP provided better protection for Dmean of the heart and left ventricle ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2020/7131590
更新日期:2020-03-26 00:00:00
abstract::Graphene is the first 2-dimensional material and possesses a plethora of original properties. Graphene and its derivatives have exhibited a great potential in a number of fields, both medical and nonmedical. The aim of this review is to set the theoretical basis for further research in developing graphene-based endova...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3180954
更新日期:2016-01-01 00:00:00
abstract::Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版
doi:10.1155/2014/483501
更新日期:2014-01-01 00:00:00
abstract::A bioenergetical analysis of swimming at intensities near competitive distances is inexistent. It was aimed to compare the transient VO2 kinetics responses and metabolic contributions whilst swimming at different velocities around VO2max. 12 trained male swimmers performed (i) an incremental protocol to determine the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/675363
更新日期:2014-01-01 00:00:00
abstract:Background:Anion gap (AG) has been proved to be associated with prognosis of many cardiovascular diseases. This study is aimed at exploring the association of AG with inhospital all-cause mortality and adverse clinical outcomes in coronary care unit (CCU) patients. Method:All data of this study was extracted from Medi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4598462
更新日期:2020-08-27 00:00:00
abstract::Bones are the most frequent site for breast cancer cells to settle and spread (metastasise); bone metastasis is considered to have a substantial impact on the quality of patients with common cancers. However, majority of breast cancers develop insensitivity to conventional chemotherapy which provides only palliation a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/391869
更新日期:2014-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldeh...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/2025636
更新日期:2019-06-24 00:00:00
abstract::Adverse perinatal outcomes in singleton IVF pregnancies have been most often explained by parental underlying diseases and so far laboratory conditions during embryo culture are still not explored well. The following review discusses the current state of knowledge on the influence of IVF laboratory procedures on the p...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3285179
更新日期:2016-01-01 00:00:00
abstract::The present study deals with the enzymatic synthesis of biodiesel by transesterification of Jatropha oil (Jatropha curcas L.) with ethanol in a solvent-free system. Seven commercial lipase preparations immobilized by covalent attachment on epoxy-polysiloxane-polyvinyl alcohol composite (epoxy-SiO2-PVA) were tested as ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1404567
更新日期:2016-01-01 00:00:00
abstract::Ischemia-reperfusion injury (IRI) is a major contributor to acute kidney injury (AKI). At present, there are no effective therapies to prevent AKI. The aim of this study was to analyse whether valproic acid (VPA), a histone deacetylase inhibitor with anti-inflammatory properties, prevents renal IRI. Male Wistar rats w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5985903
更新日期:2016-01-01 00:00:00
abstract::This study aimed to summarize the clinical features, diagnosis, and treatment of Chiari malformation type I- (CM-1-) associated syringobulbia. We performed a literature review of CM-1-associated syringobulbia in PubMed, Ovid MEDLINE, and Web of Science databases. Our concerns were the clinical features, radiologic pre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4829102
更新日期:2019-03-19 00:00:00
abstract::Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and activates the unfolded protein response path...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5958272
更新日期:2020-01-27 00:00:00
abstract::The mycotoxin zearalenone (ZEN) is a frequent contaminant of animal feeds, but its effects on fish have not yet been investigated extensively. In order to fill this gap a feeding trial with juvenile carp was conducted. Three groups of fish were fed feeds contaminated with ZEN at three concentrations (low: 332 μg kg(-1...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/420702
更新日期:2015-01-01 00:00:00
abstract::After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/835081
更新日期:2013-01-01 00:00:00
abstract::Background. Central systolic blood pressure (CSBP) has prognostic significance and simplified devices for its estimation have been introduced recently. The aim of this study was to assess the achievement of the target CSBP in treated hypertensive patients. Subjects and Methods. One hundred patients with well-controlle...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8158974
更新日期:2017-01-01 00:00:00