Abstract:
:Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular sclerosis. NADPH oxidase is a district enzymatic source of cellular ROS production and prominently expressed in podocytes (Zhang et al., 2010). In the last decade, it has become evident that NADPH oxidase-derived ROS overproduction is a key trigger of podocyte injury, such as renin-angiotensin-aldosterone system activation (Whaley-Connell et al., 2006), epithelial-to-mesenchymal transition (Zhang et al., 2011), and inflammatory priming (Abais et al., 2013). This review focuses on the mechanism of NADPH oxidase-mediated ROS in podocyte injury under different pathophysiological conditions. In addition, we also reviewed the therapeutic perspectives of NADPH oxidase in kidney diseases related to podocyte injury.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chen S,Meng XF,Zhang Cdoi
10.1155/2013/839761subject
Has Abstractpub_date
2013-01-01 00:00:00pages
839761eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章,评审abstract:Background:Diabetes mellitus (DM) is a common disease that has an adverse impact on most orthopedic surgeries, and its prevalence has gradually increased in recent years. We aim to investigate the influence of DM on comorbidities and complications of patients undergoing primary total lower extremity arthroplasty. Meth...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6661691
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:To analyze the clinical relevance of the levels of TNFα blockers and anti-drug antibodies (anti-drug Ab) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) treated with adalimumab (ADA), etanercept (ETA), or infliximab (INF) for a prolonged period of time. METHODS:Clinical characteristics...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/604872
更新日期:2015-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2014/479180.]. ...
journal_title:BioMed research international
pub_type: 撤回出版物
doi:10.1155/2016/4938464
更新日期:2016-01-01 00:00:00
abstract::Application of enzymes in biotechnological process has expanded considerably in recent years. In food and related industry, major importance was being attached to the use of enzymes in upgrading quality, increasing yields of extractive processes, product stabilization, and improvement of flavor and byproduct utilizati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2961767
更新日期:2018-04-03 00:00:00
abstract::One of the biggest obstetric challenges is the diagnosis and management of a short cervix as cervical length has an inverse relationship with risk of preterm birth. A cervical cerclage is a surgical procedure to reduce the risk of preterm birth and can be placed in an elective or emergency setting. This is a retrospec...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2018/2065232
更新日期:2018-09-30 00:00:00
abstract::The neural dysfunction is triggered by cellular and molecular events that provoke neurotoxicity and neural death. Currently, neurodegenerative diseases are increasingly common, and available treatments are focused on relieving symptoms. Based on the above, in this review we describe the participation of vitexin in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4785089
更新日期:2018-12-05 00:00:00
abstract:Aim:Little is known about the association between cancer antigen 125 (MUC16/CA125) concentrations and tumor diameter of patients with hepatocellular carcinoma (HCC) and low AFP levels. To fill this gap in our knowledge, we conducted a retrospective study of 427 patients with HCC with AFP ≤200 ng/mL who underwent R0 res...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6959637
更新日期:2019-09-29 00:00:00
abstract::Dietary polyphenols present in a broad range of plant foods have been related to beneficial health effects. This review aims to update the current information about the modulation of the gut microbiota by dietary phenolic compounds, from a perspective based on the experimental approaches used. After referring to gener...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/850902
更新日期:2015-01-01 00:00:00
abstract::A 35 KDa protein referred to as F3 was purified from the seeds of Borreria hispida by precipitation with 80% ammonium sulphate and gel filtration on Sephadex G-100 column. RP-HPLC analysis of protein fraction (F3) on an analytical C-18 column produced a single peak, detected at 220 nm. F3 showed an apparent molecular ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/179836
更新日期:2014-01-01 00:00:00
abstract::Purpose of this paper is to analyze different species' proportion of nontuberculosis mycobacteria (NTM) and susceptibility to clarithromycin of different species. 278 clinical NTM isolates were identified into species by using 16S rRNA, rpoB and hsp65. Then clarithromycin susceptibility testing against different speci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/506598
更新日期:2015-01-01 00:00:00
abstract::The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/102918
更新日期:2013-01-01 00:00:00
abstract::The aims of the present research are to investigate the possible predictors of pancreatic cancer, in particular smoking status, alcohol consumption, hypercholesterolemia, and diabetes mellitus, in patients with histologically confirmed pancreatic carcinoma and to examine the synergism between risk factors. A case-cont...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/481019
更新日期:2014-01-01 00:00:00
abstract:Background:Open laminectomy has been regarded as the standard surgical procedure for lumbar lateral recess stenosis during the last decades. Although percutaneous endoscopic lumbar decompression has led to successful results comparable with open decompression, its application in LSS with is still challenging and techni...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2601232
更新日期:2018-11-26 00:00:00
abstract::Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB). The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore,...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2017/9679843
更新日期:2017-01-01 00:00:00
abstract::Escherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome. Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with eithe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/290679
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7963972
更新日期:2016-01-01 00:00:00
abstract::Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment. Given the association of diabetes, insulin treatment, an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9472939
更新日期:2018-04-23 00:00:00
abstract::Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/143109
更新日期:2015-01-01 00:00:00
abstract:Background:Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formatio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6069390
更新日期:2020-03-16 00:00:00
abstract:Background:The well-known rubber hand paradigm induces an illusion by having participants feel the touch applied to a fake hand. In parallel, the kinesthetic mirror illusion elicits illusions of movement by moving the reflection of a participant's arm. Experimental manipulation of sensory inputs leads to emergence of t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6937328
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/7865747.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/6348625
更新日期:2018-05-14 00:00:00
abstract::A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial. The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4848652
更新日期:2018-08-13 00:00:00
abstract::Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temephos (OP), deltamethr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8603263
更新日期:2016-01-01 00:00:00
abstract:Purpose:Triple-negative breast cancer refers to breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (Her2). This study aimed to identify the key pathways and genes and find the potential initiation and progression mechanism of triple-negati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2760918
更新日期:2018-08-02 00:00:00
abstract::The classic assay for a large population biomass is time-consuming, labor intensive, and chemically expensive. This paper would find out a rapid assay for predicting biomass digestibility from biomass structural features without hydrolysis. We examined the 62 representative corn stover accessions that displayed a dive...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9167508
更新日期:2018-08-12 00:00:00
abstract::Removal of MTA from dentin by applying 37% hydrochloric acid (HCl) to reduce microhardness and push-out bond strength. Forty dentin slices were filled with WMTA and divided into two groups (n = 20). Ten slices remained untreated while others were exposed to either HCl or phosphate buffer saline (PBS) and all samples w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/469164
更新日期:2013-01-01 00:00:00
abstract::Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/341308
更新日期:2015-01-01 00:00:00
abstract::Protein phosphorylation is catalyzed by kinases which regulate many aspects that control death, movement, and cell growth. Identification of the phosphorylation site-specific kinase-substrate relationships (ssKSRs) is important for understanding cellular dynamics and provides a fundamental basis for further disease-re...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1826496
更新日期:2017-01-01 00:00:00
abstract::Vitamin B-6 has a strong antioxidative effect. It would be useful to determine whether vitamin B-6 supplementation had effects on antioxidant capacities in patients with hepatocellular carcinoma (HCC) who had recently undergone tumor resection. Thirty-three HCC patients were randomly assigned to either the placebo (n ...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/7658981
更新日期:2016-01-01 00:00:00
abstract::This study was aimed to evaluate the in vitro lethal activity of the nematophagous fungi Clonostachys rosea against 5 nematodes species belonging to different taxa. Two groups of 35 Petri dishes (PD) each were divided into 5 series of 7 (PD). Group 1 (series 1, 2, 3, 4, and 5) contained only water agar; meanwhile grou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3501827
更新日期:2018-03-20 00:00:00