Abstract:
:Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment. Given the association of diabetes, insulin treatment, and cell proliferation, our specific goal was to determine whether the liver in the diabetic state presents a greater response to DEN-induced cell cycle alteration, which is essential for the malignant transformation. Male C57BL/6 mice (four-week-old) were divided into 4 groups: C, C + DEN, T1DM, and T1DM + DEN. Mice were euthanized ten weeks after DEN injection. DEN per se produced an increase in liver lipid peroxidation levels. Besides, in T1DM + DEN, we found a greater increase in the proliferation index, in comparison with C + DEN. These results are in agreement with the increased expression observed in cell cycle progression markers: cyclin D1 and E1. In addition, a proapoptotic factor, such as activated caspase-3, evidenced a decrease in T1DM + DEN, while the Vascular Endothelial Growth Factor (VEGF) and the protooncogene p53 showed a higher increase with respect to C + DEN. Overall, the results allow us to highlight a major DEN response in T1DM, which may explain in part the greater predisposition to the development of hepatocarcinoma (HCC) during the diabetic state.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Arboatti AS,Lambertucci F,Sedlmeier MG,Pisani G,Monti J,Álvarez ML,Francés DEA,Ronco MT,Carnovale CEdoi
10.1155/2018/9472939subject
Has Abstractpub_date
2018-04-23 00:00:00pages
9472939eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章abstract::[This corrects the article DOI: 10.1155/2016/6935123.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2017/1641589
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To investigate if software simulation is practical for quantifying random error (RE) in phantom dosimetry. MATERIALS AND METHODS:We applied software error simulation to an existing dosimetry study. The specifications and the measurement values of this study were brought into the software (R version 3.0.2) to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/596858
更新日期:2015-01-01 00:00:00
abstract::Genome-wide association studies (GWAS) have extensively analyzed single SNP effects on a wide variety of common and complex diseases and found many genetic variants associated with diseases. However, there is still a large portion of the genetic variants left unexplained. This missing heritability problem might be due...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/671859
更新日期:2015-01-01 00:00:00
abstract::We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, whi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/976362
更新日期:2015-01-01 00:00:00
abstract:Purpose:We aimed to identify prognostic factors for survival and recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for patients with HCC and hepatitis C virus-related cirrhosis (HCV-cirrhosis). Methods:This retrospective cohort study followed all adult patients with HCV-cirrhosis who underw...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1487593
更新日期:2020-10-17 00:00:00
abstract::Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/690529
更新日期:2014-01-01 00:00:00
abstract::Despite being identified as a high risk cohort for psychosis, there has been relatively little research on the clinical presentation and assessment of Schizotypal Personality Disorder (SPD) in childhood. The current study aimed to develop a measure of childhood SPD (Melbourne Assessment of Schizotypy in Kids (MASK)) a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/635732
更新日期:2015-01-01 00:00:00
abstract::One of the female causes of infertility is anovulation which is treatable with gonadotropin hormones. These hormones affect the molecular organization of the uterus such as glycoconjugates that are the first site of contact between the blastocyst and the uterus. The objective of this project was to study the alteratio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3967427
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND AND AIM:The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. METHODS:Dat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/524940
更新日期:2014-01-01 00:00:00
abstract::Thirteen individual organochlorine compounds at 3 concentrations (80, 400, and 2000 ng/mL culture medium), as well as mixtures, were assayed for the estrogen receptor (ER) activation or inhibition, using a luciferase reporter gene assay (RGA). None of the PCB 138, 153, or 180 or their mixture induced a response in the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/438295
更新日期:2015-01-01 00:00:00
abstract:Background:Salivary alpha-amylase (sAA) and salivary immunoglobulin A (sIgA) have been proposed as biomarkers for research on the mucosal immune system and on stress. Expression of both sAA and sIgA has been described to follow opposing diurnal patterns. This knowledge is crucial for the interpretation of studies using...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3687416
更新日期:2019-01-14 00:00:00
abstract::Breast cancer is the most frequently occurring disease among women worldwide. The early stage of breast cancer identification is the key challenge in cancer control and prevention procedures. Although gene expression profiling helps to understand the molecular mechanism of diseases or disorder in the living system, ge...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3071013
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to evaluate, at a laboratory scale, the ability of this microorganism to grow in seawater and bioaccumulate in mussels (Mytilus galloprovincialis) maintained in constantly aerated tanks, containing twenty litres of artificial seawater. Three concentrations of A. butzleri LMG 10828(T) were tes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/153419
更新日期:2013-01-01 00:00:00
abstract::Cerebral malaria (CM) is a severe complication of and a leading cause of death due to Plasmodium falciparum infection. CM is likely the result of interrelated events, including mechanical obstruction due to parasite sequestration in the microvasculature, and upregulation of Th1 immune responses. In parallel, blood-bra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/292471
更新日期:2014-01-01 00:00:00
abstract:Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7146028
更新日期:2020-03-07 00:00:00
abstract::This study is aimed at determining how oral squamous cell carcinoma (OSCC) regulates the angiogenesis of HUVECs through miR-210-3p expression and exploring the relationship among miR-210-3p, its target protein, and the possible mechanism of angiogenesis regulation. miR-210-3p expression was detected in OSCC tissues an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2125656
更新日期:2020-07-08 00:00:00
abstract::The proper functioning of a hospital computer system is an arduous work for managers and staff. However, inconsistent policies are frequent and can produce enormous problems, such as stolen information, frequent failures, and loss of the entire or part of the hospital data. This paper presents a new method named EMRlo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/542016
更新日期:2015-01-01 00:00:00
abstract::Small bowel obstructions (SBOs) caused by adhesions are a common, often life-threatening postsurgical complication with few treatment options available for patients. This study examines the efficacy of a manual physical therapy treatment regimen on the pain and quality of life of subjects with a history of bowel obstr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7610387
更新日期:2016-01-01 00:00:00
abstract::Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/4051504
更新日期:2021-01-05 00:00:00
abstract::Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to bet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/161508
更新日期:2015-01-01 00:00:00
abstract::28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/823829
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To identify an effective method to prevent myopia progression by characterizing the regulation of matrix metalloproteinase- (MMP-) 2 expression and its secretion from scleral fibroblasts and retinal pigment epithelium (RPE) cells by miR-29a. METHODS:The effects of miR-29a on the growth of scleral fibroblasts a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2647879
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Identification of the factors that influence sedentary behaviour in older adults is important for the design of appropriate intervention strategies. In this study, we determined the prevalence of sedentary behaviour and its association with physical, cognitive, and psychosocial status among older adults resid...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9160504
更新日期:2017-01-01 00:00:00
abstract::Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/908175
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. METHODS:89 patients (124 eyes) with established myopia ra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8923819
更新日期:2017-01-01 00:00:00
abstract::Lung illness encountered in patients with rheumatic diseases bears clinical significance in terms of increased morbidity and mortality as well as potential challenges placed on patient care. Although our understanding of natural history of this important illness is still limited, epidemiologic knowledge has been accum...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6930297
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7963972
更新日期:2016-01-01 00:00:00
abstract::Previous studies have shown the therapeutic properties of ginseng and ginsenosides on hyperactive and impulsive behaviors in several psychiatric diseases. Herein, we investigated the effect of Panax ginseng Meyer (PG) on hyperactive/impulsive behaviors in a manic-like animal model, sleep deprivation (SD) rats. Male ra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3636874
更新日期:2020-10-17 00:00:00
abstract::The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0.5% 4-nitroquinoline-1-oxide (4-NQO) in propylene glycol to tongue, thrice a week for 8 weeks. From 8th to 22nd week, cisplatin (0.23 mg/kg, i.v.) was administere...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/642848
更新日期:2013-01-01 00:00:00
abstract:Background:Methadone Maintenance Treatment (MMT) program's success depends on the likelihood of reducing drop-out rate and keeping patients remaining in the program. There have been neither comprehensive studies about variation among patients who have been experiencing MMT for long period nor prediction of MMT period i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9081968
更新日期:2018-08-07 00:00:00