Abstract:
:The principle mechanism of protection of stem cells is through the expression of ATP-binding cassette (ABC) transporters. These transporters serve as the guardians of the stem cell population in the body. Unfortunately these very same ABC efflux pumps afford protection to cancer stem cells in tumors, shielding them from the adverse effects of chemotherapy. A number of strategies to circumvent the function of these transporters in cancer stem cells are currently under investigation. These strategies include the development of competitive and allosteric modulators, nanoparticle mediated delivery of inhibitors, targeted transcriptional regulation of ABC transporters, miRNA mediated inhibition, and targeting of signaling pathways that modulate ABC transporters. The role of ABC transporters in cancer stem cells will be explored in this paper and strategies aimed at overcoming drug resistance caused by these particular transporters will also be discussed.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Moitra Kdoi
10.1155/2015/635745subject
Has Abstractpub_date
2015-01-01 00:00:00pages
635745eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract:OBJECTIVE:This study evaluated the frequencies of allergic symptoms and rate of upper respiratory infections during the past year in the general population, kitchen workers (KW) and health care workers (HCW). METHODS:The European Community Respiratory Health Survey (ECRHS) was used to inquire retrospectively about ast...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/285420
更新日期:2013-01-01 00:00:00
abstract::As the fifth most common cancer in men and the eighth most common cancer in women, hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, with standard chemotherapy and radiation being minimally effective in prolonging survival. Virus hepatitis, particularly HBV and HCV infection is th...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/735672
更新日期:2014-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are composed of a group of endogenous and noncoding small RNAs which control expression of complementary target mRNAs. The extended functions of miRNAs enhance the complexity of gene-regulatory processes in cardiovascular and cerebrovascular diseases. Indeed, recent studies have shown that miRNAs ar...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/730535
更新日期:2015-01-01 00:00:00
abstract::The use of anaesthetic drugs in the treatment of oral aphthosis is one of the pharmaceutical possibilities that a doctor can use for the most painful forms. Normally, Lidocaine or Diclofenac is used to treat this disease, but they can be used for a very limited time and so they are of little practical use. In this stu...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1868254
更新日期:2018-03-11 00:00:00
abstract:Background:Shedding of the endothelial glycocalyx layer (EGL) is known to occur during major surgery, but its degradation associated with minimally invasive video-assisted thoracoscopy (VATS) remains unclear. We investigated if serum biomarkers of EGL disruption were elevated during VATS lobectomy, and whether the urin...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/2017/5969657
更新日期:2017-01-01 00:00:00
abstract::POZ/BTB domains are widespread modules detected in a variety of different biological contexts. Here, we report a biophysical characterization of the POZ/BTB of KCTD6, a protein that is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradatio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/162674
更新日期:2013-01-01 00:00:00
abstract::Natural enzyme mimics have attracted considerable attention due to leakage of enzymes and their easy denaturation during their storage and immobilization procedure. Here in this study, for the first time, a new iron oxide hydroxide, ferrihydrite - Fe1.44O0.32 (OH) 3.68 magnetic nanoparticles were synthesized by bacter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7127869
更新日期:2019-03-28 00:00:00
abstract::The objective of this study was the synthesis of folic acid- (FA-) targeted polymeric micelles of Synperonic PE/F 127-cholesteryl hemisuccinate (PF127-Chol) for specific delivery of docetaxel (DTX). Targeted or nontargeted micelles loaded with DTX were prepared via dialysis method. The effects of processing variables ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/746093
更新日期:2015-01-01 00:00:00
abstract::Rauwolfia tetraphylla L. is an important medicinal plant species which is well known for its pharmaceutically important alkaloids. In the present study, we are reporting about its conservation by in vitro clonal multiplication through the standardized protocol of indirect regeneration by using leaf and stem based call...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3698742
更新日期:2019-04-11 00:00:00
abstract::Macrophages, especially their activation state, are closely related to the progression of diabetic nephropathy. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. 1,25-Dihydroxyvitamin D3 has renoprotective roles th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/157834
更新日期:2015-01-01 00:00:00
abstract::The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9395146
更新日期:2019-12-28 00:00:00
abstract::Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature. In this review, the author offers a 3-step pathway of pathogenesis for syndactyly. The first step is initiated either by the overactivation of the WNT canonical pathway or the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9652649
更新日期:2019-09-15 00:00:00
abstract:Background:It is well known that the programmed intermittent epidural bolus (PIEB) technique effectively provides epidural anesthesia in labor. This randomized double-blind trial compared the postoperative analgesic efficacy of PIEB with that of continuous epidural infusion (CEI) in patients undergoing gynecological su...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/6297247
更新日期:2018-05-15 00:00:00
abstract::The neonatal immune system is still immature, which makes it more susceptible to the infectious agents. Neonatal immune activation is associated with increased permeability of the blood-brain barrier, causing an inflammatory cascade in the CNS and altering behavioral and neurochemical parameters. One of the hypotheses...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9573248
更新日期:2019-08-05 00:00:00
abstract::Blood pressure is the most important, modifiable risk factor for cardiovascular diseases. Lifestyle factors and also workload are the main, potential risk factors for the development of hypertension. This study focused on the early detection of unknown hypertension by screening employees in the hotel and restaurant in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6820160
更新日期:2018-04-08 00:00:00
abstract::The genus Methylobacterium is composed of pink-pigmented facultative methylotrophic (PPFM) bacteria, which are able to synthesize carotenoids and grow on reduced organic compounds containing one carbon (C1), such as methanol and methylamine. Due to their high phenotypic plasticity, these bacteria are able to colonize ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/909016
更新日期:2015-01-01 00:00:00
abstract::Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9204708
更新日期:2020-01-23 00:00:00
abstract::Blood compatibility of metallocene polyethylene (mPE) was investigated after modifying the surface using hydrochloric acid. Contact angle of the mPE exposed to HCl poses a decrease in its value which indicates increasing wettability and better blood compatibility. Surface of mPE analyzed by using FTIR revealed no sign...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/963149
更新日期:2014-01-01 00:00:00
abstract::Myofascial pain syndrome is characterized by pain and a limited range of joint motion caused by muscle contracture related to motor-end-plate dysfunction and the presence of myofascial trigger points (MTrPs). It is the most frequent cause of musculoskeletal pain, with a worldwide prevalence varying between 13.7% and 4...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9240581
更新日期:2020-01-22 00:00:00
abstract::Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation in periodontitis. In this study, we aimed to investigate the anti-inflammatory effects of quercetin on Porphyromonas gingivalis (P. gingivalis) ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6282635
更新日期:2019-08-20 00:00:00
abstract:OBJECTIVE:This study assessed the posttreatment tumor control and auditory function of vestibular schwannoma (VS) patients after CyberKnife (CK) and analyzed the possible prognostic factors of hearing loss. METHODS:We retrospectively studied 117 VS patients, with Gardner-Robertson (GR) classification grades I to IV, w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/297093
更新日期:2013-01-01 00:00:00
abstract::There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma sam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9807918
更新日期:2020-09-02 00:00:00
abstract::Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults. Despite continuous improvements in diagnosis and therapeutic method, the prognosis is still far away from expectations. The invasive phenotype of GBM is the main reason for the poor prognosis. Epithelial-mesenchymal transition (EMT) is r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1321973
更新日期:2019-04-17 00:00:00
abstract::Background. Surgical treatment of proximal humeral fractures (PHF) in osteoporotic bone of elderly patients is challenging. The aim of this retrospective study was to evaluate the clinical and radiological outcome after percutaneous reduction and internal fixation of osteoporotic PHF in geriatric patients using the se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6451849
更新日期:2016-01-01 00:00:00
abstract::The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/102918
更新日期:2013-01-01 00:00:00
abstract::Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions. The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns. 63...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/613910
更新日期:2015-01-01 00:00:00
abstract::Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities. Our knowledge about how platelets modulate inflammatory and immunity has greatly improved in recent years. In this revi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/9060143
更新日期:2016-01-01 00:00:00
abstract::Vitamin B-6 has a strong antioxidative effect. It would be useful to determine whether vitamin B-6 supplementation had effects on antioxidant capacities in patients with hepatocellular carcinoma (HCC) who had recently undergone tumor resection. Thirty-three HCC patients were randomly assigned to either the placebo (n ...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/7658981
更新日期:2016-01-01 00:00:00
abstract::Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and ce...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/575170
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage (SAH). Previous results showed that CGS 26303, an endothelin converting enzyme (ECE) inhibitor, effectively prevented and reversed arterial narrowing in animal m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/531508
更新日期:2014-01-01 00:00:00