Platelet Activation: The Mechanisms and Potential Biomarkers.

abstract：:We use hydrophobic poly(lactic-co-glycolic) acid (PLGA) to encapsulate hydrophilic ofloxacin to form drug loading microspheres. Hyaluronic acid (HA) and polylysine (Pls) were used as internal phase additives to see their influences on the drug loading and releasing. Double emulsion (water-in-oil-in-water) solvent extr...

journal_title：BioMed research international

authors： Wu G,Chen L,Li H,Deng CL,Chen XF

更新日期：2014-01-01 00:00:00

abstract：:The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE in villous 3A first trimester trophoblast cells expos...

journal_title：BioMed research international

authors： Cross CE,Tolba MF,Rondelli CM,Xu M,Abdel-Rahman SZ

更新日期：2015-01-01 00:00:00

abstract：:Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...

journal_title：BioMed research international

authors： Mellor LF,Huebner P,Cai S,Mohiti-Asli M,Taylor MA,Spang J,Shirwaiker RA,Loboa EG

更新日期：2017-01-01 00:00:00

abstract：:Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autophagy in neurodegene...

journal_title：BioMed research international

authors： Ou Z,Luo M,Niu X,Chen Y,Xie Y,He W,Song B,Xian Y,Fan D,OuYang S,Sun X

更新日期：2016-01-01 00:00:00

abstract：:The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects o...

journal_title：BioMed research international

authors： Pei K,Gui T,Kan D,Feng H,Jin Y,Yang Y,Zhang Q,Du Z,Gai Z,Wu J,Li Y

更新日期：2020-07-18 00:00:00

abstract：:The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and ...

journal_title：BioMed research international

authors： Shinoda K,Hayashi S,Fukuoka D,Torii R,Watanabe T,Nakano T

更新日期：2016-01-01 00:00:00

abstract：:ELMO3 is a member of the engulfment and cell motility (ELMO) protein family, which plays a vital role in the process of chemotaxis and metastasis of tumor cells. However, remarkably little is known about the role of ELMO3 in cancer. The present study was conducted to investigate the function and role of ELMO3 in gastr...

journal_title：BioMed research international

authors： Hu Y,Yu Q,Zhong Y,Shen W,Zhou X,Liu X,Xu M,Zhou N,Min W,Gao D

更新日期：2018-09-24 00:00:00

abstract：:Moringa grows in the tropical and subtropical regions of the world. The genus Moringa belongs to family Moringaceae. It is found to possess various medicinal uses including hypoglycemic, analgesic, anti-inflammatory, hypolipidemic, and antioxidant activities. In this study, we investigated the antimicrobial and the an...

journal_title：BioMed research international

authors： Mansour M,Mohamed MF,Elhalwagi A,El-Itriby HA,Shawki HH,Abdelhamid IA

更新日期：2019-01-01 00:00:00

abstract：Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...

journal_title：BioMed research international

authors： Mulatu T,Sintayehu Y,Dessie Y,Deressa M

更新日期：2020-12-29 00:00:00

abstract：OBJECTIVE:Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? METHODS AND MATERIALS:Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and exami...

journal_title：BioMed research international

authors： Sasaki S,Sasaki Y,Kunimura T,Sekizawa A,Kojima Y,Iino K

更新日期：2015-01-01 00:00:00

abstract：:Natural plant extracts contain a variety of phenolic compounds which are assigned various biological activities. Our work aims to make a quantitative and qualitative characterization of the Zest (ZL) and the Flesh (FL) of lemon (Citrus limon), to valorize the pharmacological uses of lemon, by evaluating in vitro activ...

journal_title：BioMed research international

authors： Makni M,Jemai R,Kriaa W,Chtourou Y,Fetoui H

更新日期：2018-01-15 00:00:00

abstract：Background:Flaviviridae viruses are single-stranded, positive-sense RNA viruses, which threat human constantly mediated by mosquitoes, ticks, and sandflies. Considering the recent increase in the prevalence of the family virus and its risk potential, we investigated the codon usage pattern to understand its evolutionar...

journal_title：BioMed research international

authors： Yao H,Chen M,Tang Z

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:We investigated the integron types and their relation with antibiotic resistance among A. baumannii isolates collected from intensive care unit patients, Babol, north of Iran. METHODS:In this cross-sectional study, a total of 73 bronchoalveolar lavage samples were obtained from patients in ICU. Susceptibili...

journal_title：BioMed research international

authors： Deylam Salehi M,Ferdosi-Shahandashti E,Yahyapour Y,Khafri S,Pournajaf A,Rajabnia R

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to investigate the suitability of insoluble Eudragit® water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its burst effect from HPMC K100M matrices. The process characteristics, ss-NMR analysis, in vitro dissolutio...

journal_title：BioMed research international

authors： Mašková E,Naiserová M,Kubová K,Mašek J,Pavloková S,Urbanová M,Brus J,Vysloužil J,Vetchý D

更新日期：2019-03-05 00:00:00

abstract：:This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery. Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery. The concentra...

journal_title：BioMed research international

authors： Dong N,Xu B,Wang B,Chu L,Tang X

更新日期：2015-01-01 00:00:00

abstract：:Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical techniques and perioperative care have improved postoperative outcomes, perioperative cardiovascular complications are a ...

journal_title：BioMed research international

authors： Choi JM,Kong YG,Kang JW,Kim YK

更新日期：2017-01-01 00:00:00

abstract：Background and Aims:The NF-κB pathway has been implicated in the genetic aetiology of psoriatic disease. However, since most patients with arthritis have psoriasis, discerning the genetic contributions to both aspects of psoriatic disease is not easy. Our aim was to study the association of common polymorphisms in gene...

journal_title：BioMed research international

authors： Coto-Segura P,Coto E,González-Lara L,Alonso B,Gómez J,Cuesta-Llavona E,Queiro R

更新日期：2019-11-11 00:00:00

abstract：Background:Adverse drug reactions (ADRs) are the known cause of morbidity and mortality, resulting in increased hospitalization, healthcare costs, complications, and decreased adherence in patients with depression. This study is aimed at evaluating adverse drug reactions due to antidepressants among patients with depre...

journal_title：BioMed research international

authors： Sankhi S,Marasine NR,Sankhi S,Lamichhane R

更新日期：2020-11-16 00:00:00

abstract：:Background. Neuroinflammation which presents as a possible mechanism of delirium is associated with MCP-1, an important proinflammatory factor which is expressed on astrocytes. It is known that dexmedetomidine (DEX) possesses potent anti-inflammatory properties. This study aimed to investigate the potential effects of...

journal_title：BioMed research international

authors： Liu H,Davis JR,Wu ZL,Faez Abdelgawad A

更新日期：2017-01-01 00:00:00

abstract：:Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability fac...

journal_title：BioMed research international

authors： Sekiguchi A,Kotozaki Y,Sugiura M,Nouchi R,Takeuchi H,Hanawa S,Nakagawa S,Miyauchi CM,Araki T,Sakuma A,Taki Y,Kawashima R

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Inflammation in dental pulp cells (DPCs) initiated by Lipopolysaccharide (LPS) results in dental pulp necrosis. So far, whether there is a common system regulating inflammation response and tissue regeneration remains unknown. miR-146a is closely related to inflammation. Basic fibroblast growth factor (bFG...

journal_title：BioMed research international

authors： Liu L,Shu S,Cheung GS,Wei X

更新日期：2016-01-01 00:00:00

abstract：:Introduction and Objectives. Neutrophil-to-lymphocyte ratio (NLR) has been suggested to be a simple marker of the systemic inflammatory response in critical care patients. We previously assessed the utility of NLR as a biomarker to predict tumor recurrence and cancer death in bladder cancer patients who underwent radi...

journal_title：BioMed research international

authors： Ohtake S,Kawahara T,Kasahara R,Ito H,Osaka K,Hattori Y,Teranishi JI,Makiyama K,Mizuno N,Umemoto S,Miyoshi Y,Nakaigawa N,Miyamoto H,Yao M,Uemura H

更新日期：2016-01-01 00:00:00

abstract：Background:Clinical trials based on FGFR mutation or amplification as a druggable target of FGFR inhibitors have produced disappointing clinical outcomes. Therefore, the identification of predictive biomarkers for FGFR-targeted agents has remained a crucial issue. Methods:Expression profiles of FGFs and FGFRs in 8,111...

journal_title：BioMed research international

authors： Li Y,Wu L,Tao W,Wu D,Ma F,Li N

更新日期：2020-06-03 00:00:00

abstract：:We have analyzed anatomic variations in the pectoralis major and pectoralis minor muscles of common chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) and compared them to anatomic variations in these muscles in humans (Homo sapiens). We have macroscopically dissected these muscles in six adult Pan troglodytes, ...

journal_title：BioMed research international

authors： Potau JM,Arias-Martorell J,Bello-Hellegouarch G,Casado A,Pastor JF,de Paz F,Diogo R

更新日期：2018-01-21 00:00:00

abstract：:This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tiss...

journal_title：BioMed research international

authors： Nahm KY,Heo JS,Lee JH,Lee DY,Chung KR,Ahn HW,Kim SH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Neck circumference (NC) is an anthropometric measure of obesity for upper subcutaneous adipose tissue distribution which is associated with cardiometabolic risk. This study investigated whether NC is associated with indicators of chronic kidney disease (CKD) for high cardiometabolic risk patients. METHODS:A...

journal_title：BioMed research international

authors： Liu YF,Chang ST,Lin WS,Hsu JT,Chung CM,Chang JJ,Hung KC,Chen KH,Chang CW,Chen FC,Shih YW,Chu CM

更新日期：2015-01-01 00:00:00

abstract：:To establish a reliable isoproterenol induced heart dysfunction fetal rat model and understand the switches of contractile proteins, 45 pregnant rats were divided into 15 mg/kg-once, 15 mg/kg-twice, sham-operated once, sham-operated twice, and control groups. And 18 adult rats were divided into isoproterenol-treated a...

journal_title：BioMed research international

authors： Li Y,Fang J,Hua Y,Wang C,Mu D,Zhou K

更新日期：2014-01-01 00:00:00

abstract：:Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred mo...

journal_title：BioMed research international

authors： Shahidi M,Phillips RA,Chik CL

更新日期：2019-03-13 00:00:00

abstract：Background:The aims of this study were to explore the characteristics of left ventricular (LV) functional changes in subjects with or without acute mountain sickness (AMS) and their associations with AMS incidence. Methods:A total of 589 healthy men were enrolled and took a trip from Chengdu (500 m, above sea level (a...

journal_title：BioMed research international

authors： Ke J,Liu C,Yu S,Bian S,Zhang C,Yang J,Zhang J,Jin J,Rao R,Zeng Y,Huang L

更新日期：2020-11-10 00:00:00

abstract：:Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...

journal_title：BioMed research international

authors： Ching XT,Lau YL,Fong MY,Nissapatorn V,Andiappan H

更新日期：2014-01-01 00:00:00