Bridging the gap between statistical and biological epistasis in Alzheimer's disease.

abstract：:Protein phosphorylation is one of the most widespread regulatory mechanisms in eukaryotes. Over the past decade, phosphorylation site prediction has emerged as an important problem in the field of bioinformatics. Here, we report a new method, termed Random Forest-based Phosphosite predictor 2.0 (RF-Phos 2.0), to predi...

journal_title：BioMed research international

authors： Ismail HD,Jones A,Kim JH,Newman RH,Kc DB

更新日期：2016-01-01 00:00:00

abstract：:Severe stages of acute, colonic diverticulitis can progress into intestinal perforations with peritonitis. In such cases, urgent treatment is needed, and Hartmann's procedure is the standard treatment for cases with fecal peritonitis. Peritoneal lavage may be an alternative to resection for acute diverticulitis with p...

journal_title：BioMed research international

authors： Hupfeld L,Burcharth J,Pommergaard HC,Rosenberg J

更新日期：2014-01-01 00:00:00

abstract：:Hitherto, limited clinical impact has been achieved in the treatment of glioblastoma (GBMs). Although phytochemicals found in medicinal herbs can provide mankind with new therapeutic remedies, single agent intervention has failed to bring the expected outcome in clinical trials. Therefore, combinations of several agen...

journal_title：BioMed research international

authors： Elkady AI,Hussein RA,Abu-Zinadah OA

更新日期：2014-01-01 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is defined as a disease characterized by persistent, progressive airflow limitation. Recent studies have underlined that COPD is correlated to many systemic manifestations, probably due to an underlying pattern of systemic inflammation. In COPD fractional exhaled Nitric Oxi...

journal_title：BioMed research international

authors： Malerba M,Radaeli A,Olivini A,Damiani G,Ragnoli B,Montuschi P,Ricciardolo FL

更新日期：2014-01-01 00:00:00

abstract：Background:Gegen Qinlian (GGQL) decoction is a common Chinese herbal compound for the treatment of ulcerative colitis (UC). In this study, we aimed to identify its molecular target and the mechanism involved in UC treatment by network pharmacology and molecular docking. Material and Methods. The active ingredients of P...

journal_title：BioMed research international

authors： Wei M,Li H,Li Q,Qiao Y,Ma Q,Xie R,Wang R,Liu Y,Wei C,Li B,Zheng C,Sun B,Yu B

更新日期：2020-11-24 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary mic...

journal_title：BioMed research international

authors： Salazar-Ruales C,Arguello JV,López-Cortés A,Cabrera-Andrade A,García-Cárdenas JM,Guevara-Ramírez P,Peralta P,Leone PE,Paz-Y-Miño C

更新日期：2018-11-21 00:00:00

abstract：Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...

journal_title：BioMed research international

authors： Luo Q,Zhang X

更新日期：2020-07-31 00:00:00

abstract：Background:Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data regarding the functional role of DCLK1 in breast cancer metastasis. In the present study, we s...

journal_title：BioMed research international

authors： Liu H,Wen T,Zhou Y,Fan X,Du T,Gao T,Li L,Liu J,Yang L,Yao J,Ge Y,An G

更新日期：2019-05-15 00:00:00

abstract：:Cystic echinococcosis is a serious zoonotic disease caused by Echinococcus granulosus species complex. The current study is the first attempt to determine the level of infection in domestic livestock and to explore the CE-related knowledge and awareness among livestock farmers in different districts of Khyber Pakhtunk...

journal_title：BioMed research international

authors： Haleem S,Niaz S,Qureshi NA,Ullah R,Alsaid MS,Alqahtani AS,Shahat AA

更新日期：2018-09-12 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) have an intrinsic property for homing towards tumor sites and can be used as tumor-tropic vectors for tumor therapy. But very limited studies investigated the antitumor properties of MSCs themselves. In this study we investigated the antiglioma properties of two easily accessible MS...

journal_title：BioMed research international

authors： Yang C,Lei D,Ouyang W,Ren J,Li H,Hu J,Huang S

更新日期：2014-01-01 00:00:00

abstract：:Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved du...

journal_title：BioMed research international

authors： Chang KC,Wen JD,Yang LW

更新日期：2015-01-01 00:00:00

abstract：:Giardia duodenalis is a small intestinal protozoan parasite of several terrestrial vertebrates. This work aims to assess the genotypic variability of Giardia duodenalis isolates from cattle, sheep and pigs in the Southeast of Brazil, by comparing the standard characterization between glutamate dehydrogenase (gdh) and ...

journal_title：BioMed research international

authors： Fava NM,Soares RM,Scalia LA,Kalapothakis E,Pena IF,Vieira CU,Faria ES,Cunha MJ,Couto TR,Cury MC

更新日期：2013-01-01 00:00:00

abstract：:Guanosine is an important building block for supramolecular gels owing to the unique self-assembly property that results from the unique hydrogen bond acceptors and donor groups. Guanosine-derived supramolecular hydrogels have promise in the fields of drug delivery, targeted release, tissue engineering applications, e...

journal_title：BioMed research international

authors： Chen M,Lin W,Hong L,Ji N,Zhao H

更新日期：2019-06-13 00:00:00

abstract：:Kawasaki disease (KD) is an acute systemic vasculitis of childhood with prolonged fever, and the diagnosis of KD is mainly based on clinical criteria, which is prone to misdiagnosis with other febrile infectious (FI) diseases. Currently, there remain no effective molecular markers for KD diagnosis. In this study, we a...

journal_title：BioMed research international

authors： Zhong J,Huang Q,Wang Y,Gao H,Jia H,Fan J,Liang H

更新日期：2020-04-26 00:00:00

abstract：:The expression profile of long noncoding RNA (lncRNA) in human epicardial adipose tissue (EAT) has not been widely studied. In the present study, we performed RNA sequencing to analyze the expression profiles of lncRNA and mRNA in EAT in coronary artery disease (CAD) patients with and without heart failure (HF). Our r...

journal_title：BioMed research international

authors： Zheng M,Zhao L,Yang X

更新日期：2019-07-04 00:00:00

abstract：:The purpose of the present study was to examine the convergent and divergent validity of the Biber Cognitive Estimation Test (BCET) in individuals with ABI undergoing postacute rehabilitation and to assess the measure's ability to account for unique variance in community integration following rehabilitation. Participa...

journal_title：BioMed research international

authors： Fortune DG,Richards HL

更新日期：2017-01-01 00:00:00

abstract：:Recent reports of retinal stem cells being present in several locations of the adult eye have sparked great hopes that they may be used to treat the millions of people worldwide who suffer from blindness as a result of retinal disease or injury. A population of proliferative cells derived from the ciliary body epithel...

journal_title：BioMed research international

authors： Frøen R,Johnsen EO,Nicolaissen B,Facskó A,Petrovski G,Moe MC

更新日期：2013-01-01 00:00:00

abstract：:IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), t...

journal_title：BioMed research international

authors： Fonseca-Camarillo G,Furuzawa-Carballeda J,Iturriaga-Goyon E,Yamamoto-Furusho JK

更新日期：2018-12-10 00:00:00

abstract：:Increasing age negatively affects different phases of bone fracture healing. The present study aimed to explore underlying mechanisms related to bone fracture repair in the elderly. GSE17825 public transcriptome data from the Gene Expression Omnibus database were used for analysis. First, raw data were normalized and ...

journal_title：BioMed research international

authors： Zhao SJ,Kong FQ,Fan J,Chen Y,Zhou S,Xue MX,Yin GY

更新日期：2018-12-16 00:00:00

abstract：Purpose:Triple-negative breast cancer refers to breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (Her2). This study aimed to identify the key pathways and genes and find the potential initiation and progression mechanism of triple-negati...

journal_title：BioMed research international

authors： Dong P,Yu B,Pan L,Tian X,Liu F

更新日期：2018-08-02 00:00:00

abstract：:The present study obtained a germ cell-specific marker dead end (dnd) in olive flounder (Paralichthys olivaceus) named Podnd. The tissue-specific expressions of Podnd transcripts were present in testis and ovary but were not detectable in other somatic tissues detected. SISH showed that Podnd expressed only in germ ce...

journal_title：BioMed research international

authors： Wang X,Liu Q,Xiao Y,Yang Y,Wang Y,Song Z,You F,An H,Xiao Z,Xu S,Ma D,Li J

更新日期：2015-01-01 00:00:00

abstract：:Aldosterone synthase (CYP11B2) is a key enzyme for the biosynthesis of aldosterone, which plays a significant role for the regulation of blood pressure. Excess aldosterone can cause the dysregulation of the renin-angiotensin-aldosterone system (RAAS) and lead to hypertension. Therefore, research and development of CYP...

journal_title：BioMed research international

authors： Luo G,Lu F,Qiao L,Chen X,Li G,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：:Background and Objective. Although minimally invasive surgical treatment of acute epidural hematoma attracts increasing attention, no generalized indications for the surgery have been adopted. This study aimed to evaluate the effects of minimally invasive surgery in acute epidural hematoma with various hematoma volume...

journal_title：BioMed research international

authors： Wang W

更新日期：2016-01-01 00:00:00

abstract：:The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficul...

journal_title：BioMed research international

authors： Fergus P,Hignett D,Hussain A,Al-Jumeily D,Abdel-Aziz K

更新日期：2015-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a very aggressive malignant type of tumor that currently lacks effective targeted therapies. In hematological malignancies, chimeric antigen receptor T (CAR-T) cells have shown very significant antitumor ability; however, in solid tumors, the efficacy is poor. In order to apply ...

journal_title：BioMed research international

authors： Zhao Z,Li Y,Liu W,Li X

更新日期：2020-01-02 00:00:00

abstract：:Cancer related fatigue (CRF) is a common and debilitating symptom that can influence quality of life (QoL) in cancer patients. The increase in survival times stresses for a better understanding of how CRF affects patients' QoL. This was a cross-sectional descriptive study with 148 randomly recruited prostate cancer pa...

journal_title：BioMed research international

authors： Charalambous A,Kouta C

更新日期：2016-01-01 00:00:00

abstract：Objective:This study aimed to investigate the effects of Ang-1 on neovascularization of diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 diabetic rats. Methods:Ang-1 adenoviral vector was constructed. The rat model was established by STZ and divided into four group. The Matrigel was i...

journal_title：BioMed research international

authors： Li S,Zou H,Gong M,Chen Y,Yan X,Yu L,Yang Y

更新日期：2019-01-09 00:00:00

abstract：Background:There is little data available on HBV infection and mother-to-child transmission (MTCT) in Vietnam. Objective:This study is aimed at assessing the prevalence of HBV infection and the current situation of MTCT in Haiphong, Vietnam. Methods:A transversal survey of 1721 pregnant women followed by an observati...

journal_title：BioMed research international

authors： Khue PM,Thuy Linh NT,Vinh VH,Dung LV,Nguyen Van B

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Macrosomia has become a worldwide problem with the rapid economic growth in the past few years. However, the detailed mechanism of how the macrosomia happened remains unknown. Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis. We hypothesized that serum miRNAs are poten...

journal_title：BioMed research international

authors： Hu L,Han J,Zheng F,Ma H,Chen J,Jiang Y,Jiang H

更新日期：2014-01-01 00:00:00

abstract：Background:The purpose of this study was to examine the physical activity patterns and health-related fitness levels of adolescents within the Juvenile Justice System. Methods:Participants included 68 adolescents (Mean age = 17.1 ± 1.0 years) in two secure Juvenile Justice correctional facilities in the Western USA. M...

journal_title：BioMed research international

authors： Brusseau TA,Burns RD,Hannon JC

更新日期：2018-07-15 00:00:00