Integrins in trabecular meshwork and optic nerve head: possible association with the pathogenesis of glaucoma.

Abstract:

:Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro and in vivo data strongly indicate that integrin-mediated signaling events can modulate the organization of the actin cytoskeleton in trabecular meshwork (TM) cells and are associated with astrocyte migration and microglia activation of the optic nerve head in patients with primary open angle glaucoma. Consequently, increase in resistance in the TM outflow pathways and remodeling of the optic nerve head occur, which in turn increases intraocular pressure (IOP), adds additional mechanical stress and strain to optic nerve axons, and accelerates damage of axons initially caused by optic nerve head remodeling. Integrins appear to be ideal candidates for translating physical stress and strain into cellular responses known to occur in glaucomatous optic neuropathy.

journal_name

Biomed Res Int

authors

Zhong Y,Wang J,Luo X

doi

10.1155/2013/202905

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

202905

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

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