Abstract:
:Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro and in vivo data strongly indicate that integrin-mediated signaling events can modulate the organization of the actin cytoskeleton in trabecular meshwork (TM) cells and are associated with astrocyte migration and microglia activation of the optic nerve head in patients with primary open angle glaucoma. Consequently, increase in resistance in the TM outflow pathways and remodeling of the optic nerve head occur, which in turn increases intraocular pressure (IOP), adds additional mechanical stress and strain to optic nerve axons, and accelerates damage of axons initially caused by optic nerve head remodeling. Integrins appear to be ideal candidates for translating physical stress and strain into cellular responses known to occur in glaucomatous optic neuropathy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhong Y,Wang J,Luo Xdoi
10.1155/2013/202905subject
Has Abstractpub_date
2013-01-01 00:00:00pages
202905eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章,评审abstract::The current morphologically based selection of human embryos for transfer cannot detect chromosome aneuploidies. So far, only biopsy techniques have been able to screen for chromosomal aneuploidies in the in vitro fertilization (IVF) embryos. Preimplantation genetic diagnosis (PGD) or screening (PGS) involves the biop...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/306505
更新日期:2014-01-01 00:00:00
abstract::Significant positive effects, particularly on psychological state in patients who completed the follow-up pulmonary rehabilitation programs, are indicated by a large number of studies. Yet, a remarkable proportion of selected patients drop out from these programs. In this study, we investigated existing differences on...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/401326
更新日期:2014-01-01 00:00:00
abstract::We recruited a group of 6713 consecutive Chinese patients with T2D but normal renal and liver function who were admitted to one of 81 top tertiary care hospitals in China. Mild hypoglycaemia was defined as having symptomatic hypoglycaemia in one month before hospitalization. Severe hypoglycaemia was defined as having ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/862896
更新日期:2015-01-01 00:00:00
abstract::We have evaluated the cloning and functional expression of previously described broad antimicrobial spectrum bacteriocins SRCAM 602, OR-7, E-760, and L-1077, by recombinant Pichia pastoris. Synthetic genes, matching the codon usage of P. pastoris, were designed from the known mature amino acid sequence of these bacter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/767183
更新日期:2015-01-01 00:00:00
abstract::Robot-Assisted Rehabilitation (RAR) is relevant for treating patients affected by nervous system injuries (e.g., stroke and spinal cord injury). The accurate estimation of the joint angles of the patient limbs in RAR is critical to assess the patient improvement. The economical prevalent method to estimate the patient...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2581924
更新日期:2016-01-01 00:00:00
abstract::Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1750368
更新日期:2018-02-22 00:00:00
abstract::The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/986736
更新日期:2015-01-01 00:00:00
abstract::Long-term application and extensive use of synthetic insecticides have resulted in accumulating their residues in food, milk, water, and soil and cause adverse health effects to human and ecosystems. Therefore, application of natural insecticides in agriculture and public health sectors has been increased as alternati...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4308054
更新日期:2018-10-16 00:00:00
abstract::Blood pressure is the most important, modifiable risk factor for cardiovascular diseases. Lifestyle factors and also workload are the main, potential risk factors for the development of hypertension. This study focused on the early detection of unknown hypertension by screening employees in the hotel and restaurant in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6820160
更新日期:2018-04-08 00:00:00
abstract::Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-β (TGF-β). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/802841
更新日期:2014-01-01 00:00:00
abstract::To establish a reliable isoproterenol induced heart dysfunction fetal rat model and understand the switches of contractile proteins, 45 pregnant rats were divided into 15 mg/kg-once, 15 mg/kg-twice, sham-operated once, sham-operated twice, and control groups. And 18 adult rats were divided into isoproterenol-treated a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/360687
更新日期:2014-01-01 00:00:00
abstract::WHO reported that adherence among patients with chronic diseases averages only 50% in developed countries. This is recognized as a significant public health issue, since medication nonadherence leads to poor health outcomes and increased healthcare costs. Improving medication adherence is, therefore, crucial and revea...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/217047
更新日期:2015-01-01 00:00:00
abstract::Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy placental function is the proper development of its vascular network. Poor vascularization of the placenta can lead to fetal growth restriction, preeclampsia, and in so...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/814543
更新日期:2015-01-01 00:00:00
abstract::DNA Primase Subunit 1 (PRIM1) is crucial for cancer development and progression. However, there remains a lack of comprehension concerning the clinical implication of PRIM1 in HCC. Here, aberrant expression of PRIM1 was identified in HCC according to available databases. The prognostic value of PRIM1 in patients prese...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9689312
更新日期:2020-08-22 00:00:00
abstract::The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/709846
更新日期:2015-01-01 00:00:00
abstract:Background:The aim of this article is to present a short review of noninvasive, nonpharmacological treatment methods used in somatic illnesses that fall under the umbrella of approach called behavioral medicine. Methods:The narrative review method was applied in the study. Science paper databases, including PubMed, ha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/5076516
更新日期:2020-11-03 00:00:00
abstract::Upper-limb movement analysis is important to monitor objectively rehabilitation interventions, contributing to improving the overall treatments outcomes. Simple, fast, easy-to-use, and applicable methods are required to allow routinely functional evaluation of patients with different pathologies and clinical condition...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/484131
更新日期:2015-01-01 00:00:00
abstract::A bioenergetical analysis of swimming at intensities near competitive distances is inexistent. It was aimed to compare the transient VO2 kinetics responses and metabolic contributions whilst swimming at different velocities around VO2max. 12 trained male swimmers performed (i) an incremental protocol to determine the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/675363
更新日期:2014-01-01 00:00:00
abstract::Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the secretome from the following informative cervical cell lines: SiHa (HPV16+), HeLa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4180703
更新日期:2017-01-01 00:00:00
abstract::Waldenström macroglobulinemia (WM) is a malignant lymphoplasma-proliferative disorder with IgM monoclonal gammopathy. A recent whole-genome study identified MYD88 L265P as the key mutation in WM. We investigated MYD88 mutations in conjunction with cytogenetic study in 22 consecutive Korean WM patients. Conventional G-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/363540
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Delayed union and nonunion are common complications in atypical femoral fractures (AFFs) despite having good fracture fixation. Demineralized bone matrix (DBM) is a successfully proven method for enhancing fracture healing of the long bone fracture and nonunion and should be used in AFFs. This study aimed to...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/4061539
更新日期:2016-01-01 00:00:00
abstract::Hypolactasia, or intestinal lactase deficiency, affects more than half of the world population. Currently, xylose quantification in urine after gaxilose oral administration for the noninvasive diagnosis of hypolactasia is performed with the hand-operated nonautomatable phloroglucinol reaction. This work demonstrates t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8421418
更新日期:2017-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease and its targeting of the joints indicates the presence of a candidate autoantigen(s) in synovial joints. Patients with RA show immune responses in their peripheral blood to proteoglycan (PG) aggrecan. One of the most relevant animal models of RA appears to be ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/942148
更新日期:2014-01-01 00:00:00
abstract::To overcome the issues connected to the use of autologous vascular grafts and artificial materials for reconstruction of small diameter (<6 mm) blood vessels, this study aimed to develop acellular matrix- (AM-) based vascular grafts. Rat iliac arteries were decellularized by a detergent-enzymatic treatment, whereas en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/685426
更新日期:2014-01-01 00:00:00
abstract::Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement....
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7981640
更新日期:2016-01-01 00:00:00
abstract::A dentin-cement-prosthesis complex restored with either all-porcelain, cured resin-composite, or cast base metal alloy and cemented with either of the different resin cements was trimmed into a mini-dumbbell shape for tensile testing. The fractured surfaces and characterization of the dentin-cement interface of bonded...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/656948
更新日期:2015-01-01 00:00:00
abstract::One of the female causes of infertility is anovulation which is treatable with gonadotropin hormones. These hormones affect the molecular organization of the uterus such as glycoconjugates that are the first site of contact between the blastocyst and the uterus. The objective of this project was to study the alteratio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3967427
更新日期:2020-12-04 00:00:00
abstract::An excessive pulmonary inflammatory response could explain the poor prognosis of chronic obstructive pulmonary disease (COPD) patients submitted to invasive mechanical ventilation. The aim of this study was to evaluate the response to normal tidal volume mechanical ventilation in an elastase-induced murine model of pu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5721293
更新日期:2018-12-19 00:00:00
abstract:Background:Left ventricular (LV) systolic dysfunction is common in septic shock. Global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE) is a useful marker of intrinsic left ventricular systolic function. However, the association between left ventricular GLS and outcome in septic patients i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7927353
更新日期:2020-10-21 00:00:00
abstract::This study was conducted to evaluate the effect of mesenchymal stem cells (MSCs) and a novel curcumin derivative (NCD) on HepG2 cells (hepatoma cell line) and to investigate their effect on Notch1 signaling pathway target genes. HepG2 cells were divided into HepG2 control group, HepG2 cells treated with MSC conditione...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/129629
更新日期:2013-01-01 00:00:00