Inactivation of Src-to-ezrin pathway: a possible mechanism in the ouabain-mediated inhibition of A549 cell migration.

abstract：:Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and...

journal_title：BioMed research international

authors： Pawlaczyk K,Baum E,Schwermer K,Hoppe K,Lindholm B,Breborowicz A

更新日期：2015-01-01 00:00:00

abstract：:Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve reg...

journal_title：BioMed research international

authors： Roussel E,Drolet MC,Walsh-Wilkinson E,Dhahri W,Lachance D,Gascon S,Sarrhini O,Rousseau JA,Lecomte R,Couet J,Arsenault M

更新日期：2015-01-01 00:00:00

abstract：:The normal physiological loads from muscles experienced by the spine are largely unknown due to a lack of data. The aim of this study is to investigate the effects of varying muscle directions on the outcomes predicted from finite element models of human lumbar spine. A nonlinear finite element model of L3-L5 was empl...

journal_title：BioMed research international

authors： Zhu R,Niu WX,Wang ZP,Pei XL,He B,Zeng ZL,Cheng LM

更新日期：2018-01-03 00:00:00

abstract：:Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is a complex multifactorial process. Animal models are essential to furthering understanding of the degenerative process and testing pot...

journal_title：BioMed research international

authors： Daly C,Ghosh P,Jenkin G,Oehme D,Goldschlager T

更新日期：2016-01-01 00:00:00

abstract：:Renal dysfunction is one of the most common complications of liver cirrhosis and is associated with increased morbidity and mortality. However, no available technology can simultaneously support liver and renal function in these patients. The aim of this study was to evaluate the safety and efficacy of an artificial l...

journal_title：BioMed research international

authors： Feng L,He G,Cai L,Fu C,Li Y,Weng J,Huo X,Peng Q,Gao Y

更新日期：2018-05-24 00:00:00

abstract：:CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...

journal_title：BioMed research international

authors： Garay-Canales CA,Licona-Limón I,Ortega E

更新日期：2018-03-29 00:00:00

abstract：:It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopath...

journal_title：BioMed research international

authors： Lee IK,Hsieh CJ,Chen RF,Yang ZS,Wang L,Chen CM,Liu CF,Huang CH,Lin CY,Chen YH,Yang KD,Liu JW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Inflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache...

journal_title：BioMed research international

authors： Motaghi M,Haghjooy Javanmard S,Haghdoost F,Tajadini M,Saadatnia M,Rafiee L,Zandifar A

更新日期：2013-01-01 00:00:00

abstract：:Microalgae are a promising source of omega-3. The purpose of this study was to extract lipid with a relatively high content of eicosapentaenoic acid (EPA) from Nannochloropsis gaditana using subcritical water extraction (SWE). The effects of different temperatures (156.1-273.9°C), extraction times (6.6-23.4 minutes), ...

journal_title：BioMed research international

authors： Ho BCH,Kamal SMM,Danquah MK,Harun R

更新日期：2018-12-27 00:00:00

abstract：:To protect against the environmental pollution, the present research was undertaken to enumerate the Bacterial Technologies (BTs) on the restoration of polluted urban rivers, that is, Fenghu-Song Yang River (FSR) and Xuxi River (XXR). Experimental research accounted for the physiochemical parameters (pH; temperature; ...

journal_title：BioMed research international

authors： Hashim S,Yuebo X,Ahmad F,Arslan C,Saifullah M

更新日期：2015-01-01 00:00:00

abstract：:A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/m...

journal_title：BioMed research international

authors： Osińska-Jaroszuk M,Jaszek M,Mizerska-Dudka M,Błachowicz A,Rejczak TP,Janusz G,Wydrych J,Polak J,Jarosz-Wilkołazka A,Kandefer-Szerszeń M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. METHODS:Dat...

journal_title：BioMed research international

authors： Su YJ,Huang CR,Chang WN,Tsai NW,Kung CT,Lin WC,Huang CC,Su CM,Cheng BC,Chang YT,Lu CH

更新日期：2014-01-01 00:00:00

abstract：:The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds o...

journal_title：BioMed research international

authors： Li C,Xiao ZX

更新日期：2014-01-01 00:00:00

abstract：Background:Since the dawn of human history, foodborne diseases have been a problem for all societies, and it is an increasing public health issue worldwide. The objective of this study is to examine knowledge, practice, and attitude in food safety among college students in the city Gondar, northwest Ethiopia. Methods:...

journal_title：BioMed research international

authors： Azanaw J,Dagne H,Andualem Z,Adane T

更新日期：2021-01-12 00:00:00

abstract：:Enteric fever caused by Salmonella enterica is a life-threatening systemic illness of gastrointestinal tract especially in tropical countries. Antimicrobial therapy is generally indicated but resistance towards commonly used antibiotics has limited their therapeutic usefulness. Therefore, we aimed to determine the ant...

journal_title：BioMed research international

authors： Khanal PR,Satyal D,Bhetwal A,Maharjan A,Shakya S,Tandukar S,Parajuli NP

更新日期：2017-01-01 00:00:00

abstract：:In a bioprospecting effort towards novel thermostable lipases, we assessed the lipolytic profile of 101 bacterial strains isolated from the volcanic area of Santorini, Aegean Sea, Greece. Screening of lipase activity was performed both in agar plates and liquid cultures using olive oil as carbon source. Significant di...

journal_title：BioMed research international

authors： Stathopoulou PM,Savvides AL,Karagouni AD,Hatzinikolaou DG

更新日期：2013-01-01 00:00:00

abstract：:The chromosomal changes accompanying bivalve evolution are an area about which few reports have been published. To improve our understanding on chromosome evolution in Veneridae, ribosomal RNA gene clusters were mapped by fluorescent in situ hybridization (FISH) to chromosomes of five species of venerid clams (Venerup...

journal_title：BioMed research international

authors： Pérez-García C,Hurtado NS,Morán P,Pasantes JJ

更新日期：2014-01-01 00:00:00

abstract：:Trichoderma spp. are important biocontrol filamentous fungi, which are widely used for their adaptability, broad antimicrobial spectrum, and various antagonistic mechanisms. In our previous studies, we cloned thga1 gene encoding GαI protein from Trichoderma harzianum Th-33. Its knockout mutant showed that the growth r...

journal_title：BioMed research international

authors： Sun Q,Jiang X,Pang L,Wang L,Li M

更新日期：2016-01-01 00:00:00

abstract：:Substitution rates strongly depend on their nucleotide context. One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates. Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutag...

journal_title：BioMed research international

authors： Medvedeva SA,Panchin AY,Alexeevski AV,Spirin SA,Panchin YV

更新日期：2013-01-01 00:00:00

abstract：:We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, whi...

journal_title：BioMed research international

authors： Druzhkov P,Zolotykh N,Meyerov I,Alsaedi A,Shutova M,Ivanchenko M,Zaikin A

更新日期：2015-01-01 00:00:00

abstract：:This study evaluated the microtensile bond strength (μTBS) of 1-step self-etch adhesives (1-SEAs) and 2-step self-etch adhesives (2-SEAs) to pulp chamber dentin immediately after bleaching with 2 types of common bleaching techniques. Pulp chamber dentin of bovine teeth was bleached using 30% hydrogen peroxide (H2O2) s...

journal_title：BioMed research international

authors： Haruyama A,Kameyama A,Kato J,Takemoto S,Oda Y,Kawada E,Takahashi T,Furusawa M

更新日期：2016-01-01 00:00:00

abstract：:This study documented the population dynamics of Biomphalaria and associated natural infections with digenetic trematodes, along the shores of Lake Albert and Lake Victoria, recording local physicochemical factors. Over a two-and-a-half-year study period with monthly sampling, physicochemical factors were measured at ...

journal_title：BioMed research international

authors： Rowel C,Fred B,Betson M,Sousa-Figueiredo JC,Kabatereine NB,Stothard JR

更新日期：2015-01-01 00:00:00

abstract：:Human diseases are abnormal medical conditions in which multiple biological components are complicatedly involved. Nevertheless, most contributions of research have been made with a single type of genetic data such as Single Nucleotide Polymorphism (SNP) or Copy Number Variation (CNV). Furthermore, epigenetic modifica...

journal_title：BioMed research international

authors： Kang M,Kim DC,Liu C,Gao J

更新日期：2015-01-01 00:00:00

abstract：:Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system, characterized by an extremely aggressive clinical phenotype. Patients with GBM have a poor prognosis and only 3-5% of them survive for more than 5 years. The current GBM treatment standards include maximal resection followed by radiot...

journal_title：BioMed research international

authors： Szopa W,Burley TA,Kramer-Marek G,Kaspera W

更新日期：2017-01-01 00:00:00

abstract：Purpose:Accumulated evidence suggests that reproductive factors are related to different breast cancer subtypes, but most studies on these relationships are mainly focused on middle-aged and older patients, and it remains unclear how reproductive factors impact different subtypes of breast cancer in young women. Metho...

journal_title：BioMed research international

authors： Wang JM,Wang J,Zhao HG,Liu TT,Wang FY

更新日期：2020-04-06 00:00:00

abstract：Background:In resource limited settings, HIV/AIDS patients lack access to sufficient nutritious foods, which poses challenges to the success of antiretroviral therapy. HIV/AIDS and malnutrition are still major public health problems in Ethiopia. Though measuring nutritional status is an essential part of ART program, l...

journal_title：BioMed research international

authors： Gebremichael DY,Hadush KT,Kebede EM,Zegeye RT

更新日期：2018-05-06 00:00:00

abstract：:Exposure to a variety of environmental factors such as salinity, drought, metal toxicity, extreme temperature, air pollutants, ultraviolet-B (UV-B) radiation, pesticides, and pathogen infection leads to subject oxidative stress in plants, which in turn affects multiple biological processes via reactive oxygen species ...

journal_title：BioMed research international

authors： Xie X,He Z,Chen N,Tang Z,Wang Q,Cai Y

更新日期：2019-05-08 00:00:00

abstract：:Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. They attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. The formation of neutrophil extracellular traps (NETs) is the thir...

journal_title：BioMed research international

authors： Alasmari SZ

更新日期：2020-02-01 00:00:00

abstract：Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...

journal_title：BioMed research international

authors： Nie H,Hu Y,Guo W,Wang W,Yang Q,Dong Q,Tang Y,Li Q,Tang Z

更新日期：2020-06-07 00:00:00

abstract：:Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...

journal_title：BioMed research international

authors： Song L,Chen L,Zhang X,Li J,Le W

更新日期：2014-01-01 00:00:00